Results 31 to 40 of about 243,473 (347)

Positively Correlated miRNA-miRNA Regulatory Networks in Mouse Frontal Cortex During Early Stages of Alcohol Dependence [PDF]

, 2013
Although the study of gene regulation via the action of specific microRNAs (miRNAs) has experienced a boom in recent years, the analysis of genome-wide interaction networks among miRNAs and respective targeted mRNAs has lagged behind.
Blednov, Yuri A., Gorini, Giorgio, Harris, R. Adon, Mayfield, R. Dayne, Nunez, Yury O., Ponomareva, Olga N., Truitt, Jay M.   +6 more
core   +2 more sources

Identification of Hub Biomarkers and Immune and Inflammation Pathways Contributing to Kawasaki Disease Progression with RT-qPCR Verification

Journal of Immunology Research, 2023
Background. Kawasaki disease (KD) is characterized by a disordered inflammation response of unknown etiology. Immune cells are closely associated with its onset, although the immune-related genes’ expression and possibly involved immune regulatory ...
Hongjun Ba, Lili Zhang, Huimin Peng, Xiufang He, Yuese Lin, Xuandi Li, Shujuan Li, Ling Zhu, Youzhen Qin, Xing Zhang, Yao Wang   +10 more
doaj   +1 more source

One Hub-One Process: A Tool Based View on Regulatory Network Topology [PDF]

, 2007
The relationship between the regulatory design and the functionality of molecular networks is a key issue in biology. Modules and motifs have been associated to various cellular processes, thereby providing anecdotal evidence for performance based ...
Axelsen, Jacob Bock, Bernhardsson, Sebastian, Sneppen, Kim   +2 more
core   +4 more sources

ComHub: Community predictions of hubs in gene regulatory networks [PDF]

BMC Bioinformatics, 2019
AbstractSummaryHub transcription factors, regulating many target genes in gene regulatory networks (GRNs), play important roles as disease regulators and potential drug targets. However, while numerous methods have been developed to predict individual regulator-gene interactions from gene expression data, few methods focus on inferring these hubs.
Åkesson, Julia, Lubovac-Pilav, Zelmina, Magnusson, Rasmus, Gustafsson, Mika   +3 more
openaire   +6 more sources

Psoriasis Associated Hub Genes Revealed by Weighted Gene Co-Expression Network Analysis.

Cell journal, 2023
Psoriasis, an immune-mediated disorder, is a multifactorial disease with unidentified cause(s). This study aimed to discover possible biomarkers of this papulosquamous skin disease.The gene chip GSE55201, resulted from an experimental study, including 44 Psoriasis patients and 30 healthy controls was downloaded from GEO and weighted gene co-expression ...
Darvish, Zeinab, Ghanbari, Saeed, Afshar, Saeid, Tapak, Leili, Amini, Payam   +4 more
openaire   +3 more sources

SWIM: A computational tool to unveiling crucial nodes in complex biological networks [PDF]

, 2017
SWItchMiner (SWIM) is a wizard-like software implementation of a procedure, previously described, able to extract information contained in complex networks.
Colombo, Teresa, Farina, Lorenzo, Fiscon, Giulia, Gurtner, Aymone, Paci, Paola, Pavesi, Giulio   +5 more
core   +2 more sources

Identification of Biomarkers Correlated with the TNM Staging and Overall Survival of Patients with Bladder Cancer

Frontiers in Physiology, 2017
Objective: To identify candidate biomarkers correlated with clinical prognosis of patients with bladder cancer (BC).Methods: Weighted gene co-expression network analysis was applied to build a co-expression network to identify hub genes correlated with ...
Sheng Li, Sheng Li, Sheng Li, Xiaoping Liu, Tongzu Liu, Xiangyu Meng, Xiaohong Yin, Cheng Fang, Di Huang, Yue Cao, Hong Weng, Xiantao Zeng, Xiantao Zeng, Xinghuan Wang, Xinghuan Wang   +14 more
doaj   +1 more source

Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice. [PDF]

, 2016
To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington's disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue samples from HD knock-in mice with increasing CAG repeat lengths.
A Dobin, A Hodges, A Kuhn, A Pal, A Reiner, A Valencia, Andreas Tebbe, B Zhang, B Zhang, BM Bolstad, C Zuccato, CA Ross, Christoph Schaab, Daniel J Lavery, David Howland, DI Shirasaki, Doxa Chatzopoulou, DV Zaykin, EH Aylward, Eliana Marisa Ramos, ES Deneris, ES Lein, Fuying Gao, G Fishell, GA Smith, Giovanni Coppola, HT Orr, I Al-Ramahi, IS Seong, Ismael Al-Ramahi, J Cox, J Cox, J Labbadia, JA Miller, JC Jacobsen, JE Phillips, Jeffrey P Cantle, Jeffrey S Aaronson, JF Gusella, JF Gusella, Jim Rosinski, JM Dowen, JM Van Raamsdonk, JP Vonsattel, Juan Botas, K Becanovic, K Monahan, K Sharma, Karla El-Zein, LB Menalled, LB Menalled, LB Menalled, LS Kaltenbach, M Biagioli, M Heiman, M MACDONALD, M Mann, M Mielcarek, MA Pouladi, MC Oldham, MI Love, MK Lobo, MT Lin, N Wang, Nan Wang, P Giles, P Grange, P Langfelder, P Langfelder, P Langfelder, P Langfelder, P Langfelder, Peter Langfelder, PF Durrenberger, RC Gentleman, S Anders, S Horvath, S Toyoda, Sandeep Deverasetty, Seung Kwak, Steve Horvath, T Geiger, T Lu, WE Johnson, WV Chen, X Gu, X Gu, X William Yang, XH Lu, Xiao-Hong Lu, Y Benjamini, Y Guo, Y Shen, Y Wang, Yining Zhao   +94 more
core   +1 more source

LongGeneDB: a data hub for long genes [PDF]

, 2020
ABSTRACTThe human genome contains more than 4000 genes that are longer than 100 kb. These long genes require more time and resources to make a transcript than shorter genes do. Long genes have also been linked to various human diseases. Specific mechanisms are utilized by long genes to facilitate their transcription and co-transcriptional processes ...
Sohyun Moon, Yura Kim, Mariam Naghavi, Jerry Yingtao Zhao   +3 more
openaire   +1 more source

Hub Genes Associated with the Diagnosis of Diabetic Retinopathy

International Journal of General Medicine, 2021
This study aimed to identify genes that may be effective in diagnosing or treating diabetic retinopathy (DR), the most common complication of diabetes mellitus (DM).Differentially expressed genes (DEGs) were identified between DR and DM in GSE146615 dataset.
Yanhui Tang, Qi Tang, Haicheng Wei, Pinzhang Hu, Donghua Zou, Rixiong Liang, Yu Ling   +6 more
openaire   +5 more sources