Identification of the potential novel biomarkers as susceptibility gene for Wilms tumor
BMC Cancer, 2021 Background Wilms tumor (WT) is the most common malignant renal tumor in children. The aim of this study was to identify potential susceptibility gene of WT for better prognosis.
Li Liu +6 more
doaj +1 more source
The pros and comms of gene sequencing [PDF]
, 2017 Full-gene sequencing undoubtedly comes with its pluses and its minuses. In this article, the authors aim to weigh up the pros and cons not only from the point of view of the patient but also in view of the doctor's possible perspective.
Codacci Pisanelli, Giovanni +3 more
core +2 more sources
Identification of potential biomarkers of vascular calcification using bioinformatics analysis and validation in vivo [PDF]
PeerJ, 2022 Background Vascular calcification (VC) is the most widespread pathological change in diseases of the vascular system. However, we know poorly about the molecular mechanisms and effective therapeutic approaches of VC.
Chuanzhen Chen +4 more
doaj +2 more sources
Peripheral blood gene expression reveals an inflammatory transcriptomic signature in Friedreich's ataxia patients. [PDF]
, 2018 Transcriptional changes in Friedreich's ataxia (FRDA), a rare and debilitating recessive Mendelian neurodegenerative disorder, have been studied in affected but inaccessible tissues-such as dorsal root ganglia, sensory neurons and cerebellum-in animal ...
Coppola, Giovanni +11 more
core +1 more source
Nuclear pore complexes as hubs for gene regulation [PDF]
Nucleus, 2018 Nuclear pore complexes (NPCs), the channels connecting the nucleus with the cytoplasm, are the largest protein structures of the nuclear envelope. In addition to their role in regulating nucleocytoplasmic transport, increasing evidence shows that these multiprotein structures play central roles in the regulation of gene activity.
openaire +2 more sources
Integrative analysis of ferroptosis-related genes in ulcerative colitis
Journal of International Medical Research, 2021 Objective The aim of this study was to identify and validate ferroptosis-related markers in ulcerative colitis (UC) to explore new directions for UC diagnosis and treatment.
De-jun Cui +4 more
doaj +1 more source
Transcriptional landscape of epithelial and immune cell populations revealed through FACS-seq of healthy human skin. [PDF]
, 2017 Human skin consists of multiple cell types, including epithelial, immune, and stromal cells. Transcriptomic analyses have previously been performed from bulk skin samples or from epithelial and immune cells expanded in cell culture.
Ahn, Richard S +9 more
core +1 more source
SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson. [PDF]
, 2016 Parkinson's disease (PD) is one of the most common neurodegenerative disorders. A theoretical approach of our previous experiments reporting the cytoprotective effects of the Valeriana officinalis compounds extract for PD is suggested.
Andrade, Bruno +7 more
core +4 more sources
, 2023 Abstract Background The aim of this study was to identify hub genes, related transcription factors (TFs) and miRNAs from the miRNA–TF–gene interaction network in necrotizing enterocolitis (NEC). Methods Three expression data sets from GEO database that compared NEC with surgical negative controls were used to calculate differentially ...
Yuqian Su +6 more
openaire +1 more source
Co-expression Network Analysis of Biomarkers for Adrenocortical Carcinoma
Frontiers in Genetics, 2018 Adrenocortical carcinoma (ACC) is a rare malignancy with a poor prognosis. And currently, there are no specific diagnostic biomarkers for ACC. In our study, we aimed to screen biomarkers for disease diagnosis, progression and prognosis.
Lushun Yuan +8 more
doaj +1 more source