Results 91 to 100 of about 194,990 (329)

Graph Theory and Networks in Biology [PDF]

, 2006
In this paper, we present a survey of the use of graph theoretical techniques in Biology. In particular, we discuss recent work on identifying and modelling the structure of bio-molecular networks, as well as the application of centrality measures to ...
Mason, Oliver, Verwoerd, Mark
core   +3 more sources

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Bioinformatics and systems biology approach to identify the pathogenetic link of neurological pain and major depressive disorder

Experimental Biology and Medicine
Neurological pain (NP) is always accompanied by symptoms of depression, which seriously affects physical and mental health. In this study, we identified the common hub genes (Co-hub genes) and related immune cells of NP and major depressive disorder (MDD)
Jinjing Hu, Jinjing Hu, Jia Fu, Yuxin Cai, Yuxin Cai, Shuping Chen, Shuping Chen, Mengjian Qu, Mengjian Qu, Lisha Zhang, Lisha Zhang, Weichao Fan, Ziyi Wang, Qing Zeng, Qing Zeng, Jihua Zou, Jihua Zou, Jihua Zou   +17 more
doaj   +1 more source

Integrated Analysis of Multiple Microarrays Based on Raw Data Identified Novel Gene Signatures in Recurrent Implantation Failure

Frontiers in Endocrinology, 2022
BackgroundRecurrent implantation failure (RIF) is an intricate complication following IVF-ET, which refers to the situation that good-quality embryos repeatedly fail to implant following two or more IVF cycles.
Hong Zeng, Hong Zeng, Yu Fu, Lang Shen, Song Quan   +4 more
doaj   +1 more source

Identification of novel hub genes associated with gastric cancer using integrated bioinformatics analysis [PDF]

, 2021
Xiaoqing Lu, Jiaqian Zhang, Sheng‐Xiao Zhang, Jun Qiao, Mengting Qiu, Xiangrong Liu, Xiaoxia Chen, Chong Gao, Huan-Hu Zhang   +8 more
openalex   +1 more source

Gene's hubs in retinal diseases: A retinal disease network [PDF]

Heliyon, 2018
Retinal diseases associated with the dysfunction or death of photoreceptors are a major cause of blindness around the world, improvements in genetics tools, like next generation sequencing (NGS) allows the discovery of genes and genetic changes that lead to many of those retinal diseases.
J.M. Lázaro-Guevara, B.J. Flores-Robles, K. Garrido, V. Pinillos-Aransay, A. Elena-Ibáñez, L. Merino-Meléndez, J.A. López-Martínez, R. Victoriano-Lacalle   +7 more
openaire   +3 more sources

Comprehensive Analysis of Hub Genes In Prostate Cancer [PDF]

, 2021
Abstract Abstract：The present study aims to explore the involvement of hub genes in prostate cancer (PCa). Three series were used in this study: GSE46602, GSE5377, and GSE8511 from GPL570 platform in the Gene Expression Omnibus and the other resources from The Cancer Genome Atlas and UCSC Xena. A total of 47 differentially expressed genes (DEGs)
Zhi Yang, JUN MI
openaire   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Large-scale inference and graph theoretical analysis of gene-regulatory networks in B. stubtilis

, 2006
We present the methods and results of a two-stage modeling process that generates candidate gene-regulatory networks of the bacterium B. subtilis from experimentally obtained, yet mathematically underdetermined microchip array data.
Albert, Anshuman Gupta, Barabasi, Christiansen, Christiansen, Claire Christensen, Costas D. Maranas, Csete, Dauner, Dauner, Dauner, Dauner, Dauner, D’Haeseleer, Gardner, Gavin, Giot, Guelzim, Gupta, Hartemink, Ho, Holter, Ito, Jeong, Kashtan, Latora, Latora, Lee, Li, Luscombe, Mangan, Mangan, Ma’ayan, Milo, Newman, Oltvai, Réka Albert, Sauer, Shen-Orr, Uetz, Vazquez, Yeung, Zaslaver   +42 more
core   +1 more source