Results 51 to 60 of about 107,360 (249)

Identification of potential ferroptosis-associated biomarkers in rheumatoid arthritis

Frontiers in Immunology, 2023
BackgroundRheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by inflammation and gradual joint degeneration, resulting in function disability.
Xu He, Xu He, Juqi Zhang, Juqi Zhang, Juqi Zhang, Mingli Gong, Yanlun Gu, Yanlun Gu, Yanlun Gu, Bingqi Dong, Xiaocong Pang, Xiaocong Pang, Chenglong Zhang, Yimin Cui, Yimin Cui, Yimin Cui   +15 more
doaj   +1 more source

Hub-Centered Gene Network Reconstruction Using Automatic Relevance Determination

PLoS ONE, 2012
Network inference deals with the reconstruction of biological networks from experimental data. A variety of different reverse engineering techniques are available; they differ in the underlying assumptions and mathematical models used. One common problem for all approaches stems from the complexity of the task, due to the combinatorial explosion of ...
M. Böck, S. Ogishima, H. Tanaka, S. Kramer, L. Kaderali   +4 more
openaire   +4 more sources

Bioinformatics analysis of hub genes as osteoarthritis prognostic biomarkers

Scientific Reports, 2023
AbstractOsteoarthritis (OA) is a progressive cartilage degradation disease, concomitant with synovitis, osteophyte formation, and subchondral bone sclerosis. Over 37% of the elderly population is affected by OA, and the number of cases is increasing as the global population ages.
Junfeng Zeng, Xinhao Jiang, Mo Jiang, Yuexia Cao, Yi Jiang   +4 more
openaire   +3 more sources

Significance of hub genes and immune cell infiltration identified by bioinformatics analysis in pelvic organ prolapse [PDF]

PeerJ, 2020
Objective Pelvic organ prolapse (POP) refers to the decline of pelvic organ position and dysfunction caused by weak pelvic floor support. The aim of the present study was to screen the hub genes and immune cell infiltration related to POP disease ...
Ying Zhao, Zhijun Xia, Te Lin, Yitong Yin   +3 more
doaj   +2 more sources

Discovering new hub genes of dilated cardiomyopathy

ESC Heart Failure
AbstractAimsDilated cardiomyopathy (DCM) has a poor prognosis and exhibits a complex and diverse aetiology and genetic profile. The genes responsible for the pathogenesis of DCM have not been fully identified. The present study aimed to explore new hub genes of DCM by mining the human DCM databases and further by experimental validation.MethodsTwo gene
Jun‐Yan Zhu, Yu Han, Jing‐Yu Yang, De‐Ping Wang, Li‐Juan Gao, Teng Sun, Yan‐Lin Feng, Zhong‐Mei He, Bin Zhou, Ji‐Min Cao   +9 more
openaire   +3 more sources

Study of Osteoarthritis‐Related Hub Genes Based on Bioinformatics Analysis [PDF]

BioMed Research International, 2020
Osteoarthritis (OA) is a common cause of morbidity and disability worldwide. However, the pathogenesis of OA is unclear. Therefore, this study was conducted to characterize the pathogenesis and implicated genes of OA. The gene expression profiles of GSE82107 and GSE55235 were downloaded from the Gene Expression Omnibus database.
Zhengqing Zhu, Lei Zhong, Ronghang Li, Yuzhe Liu, Xiangrun Chen, Zhaoyan Li, Lanfeng Huang   +6 more
openaire   +2 more sources

Identification of featured necroptosis-related genes and imbalanced immune infiltration in sepsis via machine learning

Frontiers in Genetics, 2023
Background: The precise diagnostic and prognostic biological markers were needed in immunotherapy for sepsis. Considering the role of necroptosis and immune cell infiltration in sepsis, differentially expressed necroptosis-related genes (DE-NRGs) were ...
Han She, Han She, Lei Tan, Lei Tan, Ruibo Yang, Jie Zheng, Yi Wang, Yi Wang, Yuanlin Du, Xiaoyong Peng, Qinghui Li, Haibin Lu, Xinming Xiang, Yi Hu, Liangming Liu, Tao Li   +15 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Identification of uterine leiomyosarcoma-associated hub genes and immune cell infiltration pattern using weighted co-expression network analysis and CIBERSORT algorithm

World Journal of Surgical Oncology, 2021
Background While large-scale genomic analyses symbolize a precious attempt to decipher the molecular foundation of uterine leiomyosarcoma (ULMS), bioinformatics results associated with the occurrence of ULMS based totally on WGCNA and CIBERSORT have not ...
Xiaoqing Shen, Zhujuan Yang, Songwei Feng, Yi Li   +3 more
doaj   +1 more source

Identification of Hub Genes Associated With Immune Infiltration and Predict Prognosis in Hepatocellular Carcinoma via Bioinformatics Approaches

Frontiers in Genetics, 2021
AimsIn the cancer-related research field, there is currently a major need for a greater number of valuable biomarkers to predict the prognosis of hepatocellular carcinoma (HCC).
Huaping Chen, Junrong Wu, Liuyi Lu, Zuojian Hu, Xi Li, Li Huang, Xiaolian Zhang, Mingxing Chen, Xue Qin, Li Xie   +9 more
doaj   +1 more source