Results 91 to 100 of about 6,271,732 (295)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Does human disturbance affect physiological traits of Two-banded Plovers nesting on an urban beach?

Avian Conservation and Ecology, 2023
In coastal Patagonia, Argentina, shorebird breeding habitats overlap with high levels of human recreational activities, such as dog-walking and driving motorized vehicles.
Glenda D. Hevia, Marcelo Bertellotti, Daniel Gibson, Verónica L. D'Amico   +3 more
doaj  

Aspects Concerning the Opportunities of Career Development in the Human Resources Domain [PDF]

The function of human resources is an unusual matter concerning the evolution of other functions of the organization. The enriching and changing process of its status determined, at the same time, a movement of its instruments and activities as far as ...
Bianca Forosigan, Horia Demian, Maria Madela Abrudan, Marius Forosigan   +3 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

No Grice: Computers that Lie, Deceive and Conceal [PDF]

, 2011
In the future our daily life interactions with other people, with computers, robots and smart environments will be recorded and interpreted by computers or embedded intelligence in environments, furniture, robots, displays, and wearables.
Nijholt, Anton
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Attribution Identification of Runoff Change Before and After Impoundment in the Three Gorges Reservoir Area Based on Budyko Hypothesis

Shuitu Baochi Xuebao
[Objective] Runoff changes under the combined influence of climate change and human activities. Exploring the temporal and spatial evolution of runoff and its causes has important guiding significance for the scientific operation of reservoirs and the ...
CHEN Meng’en, WEI Xing, ZHOU Yulin, SHI Ruibo, LI Yineng   +4 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Strong Agricultural Resilience to 2022 Southern China Drought

Earth's Future
Meteorological drought, especially when influenced by human activities, significantly impacts agriculture. We assessed the Yangtze River Basin (YRB)’s crop ecosystem resilience during the 2022 southern China drought.
Yijing Cao, Yongqiang Zhang, Jing Tian, Xiaojie Li, Zixuan Tang, Xuening Yang, Xuanze Zhang, Ning Ma   +7 more
doaj   +1 more source