Results 111 to 120 of about 13,117,722 (295)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Human-centered Design (HCD) activities, descriptions, and outputs.
Human-centered Design (HCD) activities, descriptions, and outputs.
Mihaja Raonivololona (18340048) +3 more
core +1 more source
LandAn accurate analysis of the relationship between humans and the land in oasis areas is essential for the formulation of policies for differentiated oasis urban development and resource management measures.
Xuedi Yang +6 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Immediate Release, August 17, 2012
, 2012 "August 17, 2012.""The Kansas Human Rights Commission (KHRC) is pleased to announce that Robert G. Lay, formerly of Topeka, Kansas, and Rehelio "Ray" A.
Kansas Human Rights Commission.
core
Human control in mineral processing plants: An operator centered investigation
, 2010 Mineral processing plants present a complex and dynamic process control environment where human operation is widely regarded as the bottleneck of overall plant performance. This paper presents an initial field study to investigate factors and issues that
Powell, Malcolm +2 more
core +1 more source