Results 121 to 130 of about 6,271,732 (295)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Vegetation, Architecture, and Human Activities: Reconstructing Land Use History from the Late Yangshao Period in Zhengzhou Region, Central China

Land
In recent decades, a large number of houses from the Late Yangshao period have been excavated in Zhengzhou. They are basically single-level buildings with wood skeletons and mud walls and use a huge amount of timber resources.
Xia Wang, Junjie Xu, Duowen Mo, Hui Wang, Peng Lu   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Source Tracing of Sulfate in a Karst Groundwater System in Tai’an City, Shandong Province

Yankuang ceshi
In recent years, the concentration of sulfate in groundwater in northern karst areas has increased significantly, which not only poses a potential threat to human health, but also affects the safety of industrial and agricultural water and the ...
Xiaobo LI, Mingyi LI, Xueming ZHANG, Xiaoqian MA, Dawei SUN, Qinglu MENG, Chuanming MA   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Transportation networks and the location of human activities [PDF]

The impact of transportation networks on the location of human activities is a surprisingly neglected topic in economic geography. Using the simple plant location problem, this paper investigates such an impact in the case of a few idealized networks. It
Dominique Peeters, Isabelle Thomas, Jacques Thisse   +2 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Specimen records of spiders (Arachnida: Araneae) by monthly census for 3 years in forest areas of Yakushima Island, Japan

Biodiversity Data Journal, 2017
Takeshi Osawa, Yuki Baba, Tatsumi Suguro, Noriaki Naya, Takeo Yamauchi   +4 more
doaj   +3 more sources

Human Activity Recognition [PDF]

, 2005
Motion is an important cue for the human visual system Mobiles have fascinated children, Zeno (circa 500 B.C.) studied moving arrows to pose a paradox and Zeke is investigating the human brain devoted to the understanding of motion. In computer vision research, motion has played an important role for the past thirty years.
openaire   +1 more source