Results 251 to 260 of about 23,332,679 (341)

A hybrid TCN-GRU model for classifying human activities using smartphone inertial signals. [PDF]

PLoS One
Raja Sekaran S, Pang YH, You LZ, Yin OS.
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Assessing the impact of human activities on ecosystem asset dynamics in the Yellow River Basin from 2001 to 2020. [PDF]

Sci Rep
Ming L, Wang Y, Liu G, Meng L, Chen X.
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Editorial: Degradation, conservation and ecological restoration of seagrass beds under intensifying global changes

Frontiers in Marine Science
Shaochun Xu, Shaochun Xu, Shaochun Xu, Shaochun Xu, Richard K. F. Unsworth, Richard K. F. Unsworth, Juan D. Gaitan-Espitia, Yi Zhou, Yi Zhou, Yi Zhou, Yi Zhou   +10 more
doaj   +1 more source

Human activities reshape the spatial overlap between North Chinese leopard and its wild ungulate prey. [PDF]

Front Zool
Wang Y, Liu M, Xia F, Li S.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Toward Concurrent Identification of Human Activities with a Single Unifying Neural Network Classification: First Step. [PDF]

Sensors (Basel)
Smith A, Azeem M, Odhiambo CO, Wright PJ, Diktas HE, Upton S, Martin CK, Froeliger B, Corbett CF, Valafar H.   +9 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Zoonotic Parasites and Their Association With Human Activities in Northern Tanzania: An Integrated Ecosystem Approach for One Health. [PDF]

J Parasitol Res
Ndossi BA, Mjingo EE, Park H, Lee D, Bia MM, Yang H, Seo S, Eom KS.   +7 more
europepmc   +1 more source