Results 261 to 270 of about 23,332,679 (341)

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Fighting Antibiotic Resistance: Insights Into Human Barriers and New Opportunities: Antibiotic Resistance Constantly Rises With the Development of Human Activities. We discuss Barriers and Opportunities to Get It Under Control. [PDF]

Bioessays
Pitiot A, Rolin C, Seguin-Devaux C, Zimmer J.   +3 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Potential associations between Schistosoma mansoni infection and physico-chemical characteristics and water-related human activities in Côte d'Ivoire: a cross-sectional study. [PDF]

Parasit Vectors
Sékré JK, Diakité NR, Assaré RK, Kouadio JN, Coulibaly G, Konan CK, Kouamin AC, Méité A, Hattendorf J, Ouattara M, Utzinger J, N'Goran EK.   +11 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Agricultural drought-driven mechanism of coupled climate and human activities in the karst basin of southern China. [PDF]

Sci Rep
Pan S, He Z, Gu X, Xu M, Chen L, Yang S, Tan H.   +6 more
europepmc   +1 more source

Assessment of the Potential Suitable Habitat of Apriona rugicollis Chevrolat, 1852 (Coleoptera: Cerambycidae) Under Climate Change and Human Activities Based on the Biomod2 Ensemble Model. [PDF]

Insects
Zhang L, Yang C, Xie G, Wang P, Wang W.
europepmc   +1 more source

Reconstructing colonization dynamics to establish how human activities transformed island biodiversity. [PDF]

Sci Rep
Tomlinson S, Lomolino MV, Anderson A, Austin JJ, Brown SC, Haythorne S, Perry GLW, Wilmshurst JM, Wood JR, Fordham DA.   +9 more
europepmc   +1 more source

Facilitating giant panda crossings of national highway in Wolong area of Giant Panda National Park amid human activities. [PDF]

Ecol Evol
Zhang H, Shi Z, Feng B, Liu Y, Tang Z, Dong X, Gu X, Qi D, Xu W, Zhou C, Zhang J.   +10 more
europepmc   +1 more source

Eco-environmental changes due to human activities in the Erhai Lake Basin from 1990 to 2020. [PDF]

Sci Rep
Liu X, Chen J, Tang BH, He L, Xu Y, Yang C.   +5 more
europepmc   +1 more source