Results 101 to 110 of about 25,437 (212)

Crystal structures of trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymes [PDF]

, 2013
Oligopeptidase B cleaves after basic amino acids in peptides up to 30 residues. As a virulence factor in bacteria and trypanosomatid pathogens that is absent in higher eukaryotes, this is a promising drug target.
Canning, Peter, Fülöp, Vilmos, Morty, Rory E., Rea, Dean   +3 more
core   +3 more sources

A Potential Entomological and Epidemiological Drivers for Reemergence of Human African Trypanosomiasis in Ethiopia after 55 Years

, 2023
Abate Waldetensai, Ebise Abose, Getachew Abébé, Henok Tadesse, Behabilom Meharenet, Moges Hidoto, Hailemariam Defabachew, Araya Eukubay, Bekele Alemayehu, Geremew Gonfa, Tesfa Wakgari, Nigus Manaye, Tsegalem Hailemichael, Kokeb Kore, Netsanet Asfaw, Jemal Yousuf Hassen, Wondu Mengesha, Daniel Tsega, Adugna Abera, Belachew Bokecho, Fiseha Lemango, Tariku Melese, Yimer Mulugeta, Mesfin Wossen, Feyisa Regassa, Geremew Tasew, Abraham Ali   +26 more
openalex   +2 more sources

High-Throughput Screening Platform for Natural Product–Based Drug Discovery Against 3 Neglected Tropical Diseases: Human African Trypanosomiasis, Leishmaniasis, and Chagas Disease [PDF]

, 2014
Frederick Annang, Guiomar Pérez‐Moreno, Raquel García‐Hernández, Carlos Cordón-Obras, Jesús Martı́n, José R. Tormo, Lorena Rodríguez, Nuria de Pedro, Verónica Gómez‐Pérez, María Valente, Fernando Reyes, Olga Genilloud, Francisca Vicente, Santiago Castanys, Luis M. Ruiz‐Pérez, Miguel Navarro, Francisco Gamarro, Dolores González‐Pacanowska   +17 more
openalex   +1 more source

Evaluation of the micro-CATT, CATT/Trypanosoma brucei gambiense, and LATEX/T. b. gambiense methods for serodiagnosis and surveillance of human African trypanosomiasis in West and Central Africa

Bulletin of the World Health Organization, 2002
OBJECTIVE: To evaluate the performance of serological tests using dried blood on filter-papers (micro-card agglutination test for trypanosomiasis (micro-CATT)) performed under field and laboratory conditions and using whole blood ((CATT/T.b.
Truc Philippe, Lejon Veerle, Magnus Eddy, Jamonneau Vincent, Nangouma Auguste, Verloo Didier, Penchenier Laurent, Büscher Philippe   +7 more
doaj  

Trypanosomabrucei gambienseSpliced Leader RNA Is a More Specific Marker for Cure of Human African Trypanosomiasis ThanT. b. gambienseDNA: Table 1. [PDF]

, 2015
Hamidou Ilboudo, Oumou Camara, Sophie Ravel, Bruno Bucheton, Veerle Lejon, Mamadou Camara, Jacques Kaboré, Vincent Jamonneau, Stijn Deborggraeve   +8 more
openalex   +1 more source

Front Cover: Structure‐Activity Relationships, Tolerability and Efficacy of Microtubule‐Active 1,2,4‐Triazolo[1,5‐a]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis (ChemMedChem 20/2023) [PDF]

, 2023
Ludovica Monti, Lawrence J. Liu, Carmine Varricchio, Bobby Lucero, Thibault Alle, Wenqian Yang, Ido Bem‐Shalom, Michael K. Gilson, Kurt R. Brunden, Andrea Brancale, Conor R. Caffrey, Carlo Ballatore   +11 more
openalex   +1 more source

Drug Discovery for Human African Trypanosomiasis: Identification of Novel Scaffolds by the Newly Developed HTS SYBR Green Assay for Trypanosoma brucei [PDF]

, 2014
Joana Faria, Carolina Borsoi Moraes, Rita Song, Bruno S. Pascoalino, Nakyung Lee, Jair L. Siqueira-Neto, Deu John M. Cruz, Tanya Parkinson, Jean‐Robert Ioset, Anabela Cordeiro‐da‐Silva, Lúcio H. Freitas-Júnior   +10 more
openalex   +1 more source

Africa and the Cattle Without History

Global Environment
African historiography of tsetse-borne trypanosomiasis has yet to fully embrace the genetic basis of cattle tolerance to the disease due to the literature’s emphasis on human illness and landscape modification.
Tad Brown
doaj   +1 more source

Update of transmission modelling and projections of gambiense human African trypanosomiasis in the Mandoul focus, Chad [PDF]

, 2022
Kat S. Rock, Ching-I Huang, R. E. Crump, Paul R. Bessell, Paul E. Brown, Iñaki Tirados, Philippe Solano, Marina Antillón, Albert Picado, Severin Mbainda, Justin Darnas, Emily Crowley, Stephen J. Torr, Mallaye Péka   +13 more
openalex   +1 more source

A murine model of Trypanosoma brucei-induced myocarditis and cardiac dysfunction

Microbiology Spectrum
Trypanosoma brucei is a protozoan parasite that causes human and animal African trypanosomiases (HAT and AAT). Cardiac symptoms are commonly reported in HAT patients, and intracardiac parasites with accompanying myocarditis have been observed in both ...
Nathan P. Crilly, Marcelle Dina Zita, Alexander K. Beaver, Polina Sysa-Shah, Aashik Bhalodia, Kathy Gabrielson, Luigi Adamo, Monica R. Mugnier   +7 more
doaj   +1 more source