Results 161 to 170 of about 180,484 (312)

Why not "do simple things in a simple way": Use of the Pap test as the first step in screening genetic stability for human cultured stem cell therapy? [PDF]

, 2011
The aim of this study was to analyze adipose tissue-derived mesenchymal stem cells (AT-MSCs) using the Pap test as a first screening step to evaluate genetic stability.
Ana Carolina Irioda, Carolina Maria Costa de Oliveira Souza, Diogo Kuczera, Eduardo Aliprandini, Julio C Francisco, Katherine Athayde Teixeira de Carvalho, Larissa Zocche, Lismary Mesquita, Luiz Cesar Guarita-Souza, Mariester Malvezzi, Miriam Beltrame, Rafael Vargas, Reginaldo J. Ferreira, Ricardo C Cunha   +13 more
core   +1 more source

Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction

Advanced Science, EarlyView.
We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang, Kai Dai, Tong Shen, Zehua Gao, Fengying Yan, Yuke Feng, Xuanlin Wang, Shaozhen Zhang, Jing Wang, Changsheng Liu   +9 more
wiley   +1 more source

Long noncoding RNA KCNMA1-AS1 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells by activating the SMAD9 signaling pathway. [PDF]

Biol Direct, 2023
Mai Z, Liu J, Jiang X, Gu W, Wang W, Li S, Schmalz G, Xiao H, Zhao J.   +8 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

MiR-422a promotes adipogenesis via MeCP2 downregulation in human bone marrow mesenchymal stem cells. [PDF]

Cell Mol Life Sci, 2023
Giuliani A, Sabbatinelli J, Amatori S, Graciotti L, Silvestrini A, Matacchione G, Ramini D, Mensà E, Prattichizzo F, Babini L, Mattiucci D, Busilacchi EM, Bacalini MG, Espinosa E, Lattanzio F, Procopio AD, Olivieri F, Poloni A, Fanelli M, Rippo MR.   +19 more
europepmc   +1 more source

Biological features of mesenchymal stem cells from human bone marrow.

Chinese medical journal, 2002
To study the biological characteristics of mesenchymal stem cells (MSCs) from human bone marrow.A culture of mesenchymal stem cells was initiated from bone marrow low-density mononuclear cells separated by Percoll Centrifugation and maintained in low-glucose Dulbecco's modified Eagle's medium (DMEM) with 10% selected fetal calf serum.
Z, Guo, J, Yang, X, Liu, X, Li, C, Hou, P H, Tang, N, Mao   +6 more
openaire   +1 more source

Senomorphic Small Extracellular Vesicles Delivered by a Tissue‐Adhesive α‐Lipoic‐Acid Hydrogel Enable Immuno‐Rejuvenation for Bone‐Tendon Interface Regeneration

Advanced Science, EarlyView.
This work identifies M1 macrophage‐mediated inflammation as a key driver of BMSC senescence and bone microstructural deterioration at the enthesis. A tissue‐adhesive hydrogel delivering senomorphic small extracellular vesicles suppresses this inflammatory‐senescent cascade and enhances BMSC resilience by inhibiting the cGAS‐STING‐NF‐κB pathway.
Lingzhi Kong, Wei Song, Wencai Liu, Hui Xu, Yuhao Yu, Xinyue Yang, Haiyan Li, Yanlun Zhu, Yaohua He   +8 more
wiley   +1 more source

The effect of microvesicles derived from K562 cells on proliferation and apoptosis of human bone marrow mesenchymal stem cells. [PDF]

Iran J Basic Med Sci, 2023
Rassaei N, Abbaszade Dibavar M, Soleimani M, Atashi A, Mohammadi MH, Allahbakhshian Farsani M, Shahsavan S.   +6 more
europepmc   +1 more source

Influence of commonly used pharmaceutical agents on equine bone marrow-derived mesenchymal stem cell viability [PDF]

, 2017
Ankrum, Becerra, Bohannon, Broeckx, Chang, Distelhorst, Donega, Dregalla, Ferris, Fredriksson, Frisbie, Garcia-Villar, Garvican, Godwin, Guest, Guest, Hammer, Keegan, McIlwraith, Müller, Nagy, Parker, Qiu, Salonen, Smith, Smith, Sole, Sole, Strober, Tan, Wilke, Wyles, Zhang   +32 more
core   +2 more sources

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source