Results 111 to 120 of about 113,516 (292)

The role of bone marrow derived cells in cardiac repair

, 2012
PhDCurrent pharmacological therapies fail to address the final end-point of cardiac ischaemia — the death and dysfunction of cardiomyocytes. Advances in stem cell biology have provided hope, for the first time, of addressing this underlying pathology.
Lovell, Matthew J, Lovell, Matthew J.
core  

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source

NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source

"Studies on the cardiomyocytic potential of dermal stem cells” [PDF]

, 2008
In Europe, diseases of the heart and circulatory system are the main cause of death; 48% of all deaths are from coronary heart disease, accounting for over 4.30 million deaths each year (European cardiovascular disease statistics 2008). Identifying stem
Cormack, Suzanne Marie
core  

Phosphodiesterase function and activity in isolated cardiomyocytes from rat, guinea pig and human heart [PDF]

, 2009
Phosphodiesterases (PDEs) play a key role in the control of cardiac contraction. PDE inhibitors are associated with cardiotoxicity, and increased knowledge of cardiomyocyte PDEs is required for improved pharmaceutical development.
Johnson, William Benjamin
core   +1 more source

No functional TRPA1 in cardiomyocytes

, 2021
Aim There is mounting evidence that TRPA1 has a role in cardiac physiology and pathophysiology. We aim to clarify the site of TRPA1 expression in the heart and in particular whether the channel is expressed in cardiomyocytes.
Bruno K. Podesser, Attila Kiss, Lukas F. Reissig, Fischer, Michael J.M., Ciotu, Cosmin I., Reissig, Lukas F., Rojas-Galvan, Natalia S., Michael J. M. Fischer, Heber, Stefan, Hoebart, Clara, Natalia S. Rojas‐Galvan, Aykac, Ibrahim, Clara Hoebart, Weninger, Wolfgang Johann, Cosmin I. Ciotu, Ibrahim Aykac, Podesser, Bruno Karl, Stefan Heber, Kiss, Attila, Wolfgang J. Weninger   +19 more
core   +1 more source

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo

Nature Communications, 2017
Adult mammalian cardiomyocytes are predominantly binucleated and unable to divide. Using single nuclear RNA-sequencing of cardiomyocytes from mouse and human failing and non-failing adult hearts, See et al. show that some cardiomyocytes respond to stress
Kelvin See, Wilson L. W. Tan, Eng How Lim, Zenia Tiang, Li Ting Lee, Peter Y. Q. Li, Tuan D. A. Luu, Matthew Ackers-Johnson, Roger S. Foo   +8 more
doaj   +1 more source

Deriving Cardiomyocytes from Human Amniocytes [PDF]

, 2018
ABSTRACT Many forms of congenital heart disease (CHD) have high morbidity-mortality rates and require challenging surgeries. Human amniocytes have important stem cell characteristics and could potentially provide patient-specific tissue for repairs of some types of CHDs.
Maguire, Colin T., Sunderland, Ryan, Demarest, Bradley, Gorsi, Bushra, Jackson, Josh, Lopez-Izquierdo, Angelica, Tristani-Firouzi, Martin, Yost, H. Joseph, Condic, Maureen L.   +8 more
openaire   +1 more source

Effects of Met on Dox induced cytotoxicity in RL-14 human cardiomyocytes and rat primary cardiomyocytes.

, 2014
RL-14 human immortalized fetal cardiomyocytes and rat neonatal primary cardiomyocytes (Rat CM) were cultured with same conditions as we did for H9c2 cells, and (A) cell viabilities, (B) LDH leakages, (C) ROS generations and (D) [Ca2+]i were evaluated at ...
Laura C. Kobashigawa (616302), James F. Padbury (173674), Naohiro Yano (173654), Yi-Tang Tseng (341569), Yan Chun Xu (616303)   +4 more
core   +1 more source