Results 121 to 130 of about 113,516 (292)

The effect of exercise training on transverse tubules in normal, remodeled, and reverse remodeled hearts [PDF]

, 2011
The response of transverse (T)-tubules to exercise training in health and disease remains unclear. Therefore, we studied the effect of exercise training on the density and spacing of left ventricle cardiomyocyte T-tubules in normal and remodeled hearts ...
Kemi, Ole J., Wisloff, Ulrik, Koch, Lauren G., Morten A. Hoydal, MacQuaide, Niall, Haram, Per M., Godfrey L. Smith, Steven L. Britton, Hoydal, Morten A., Smith, Godfrey L., Ellingsen, Oyvind, Per M. Haram, Lauren G. Koch, Oyvind Ellingsen, Britton, Steven L., Niall MacQuaide, Ole J. Kemi, Ulrik Wisloff   +17 more
core   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Adhesion studies in adult human cardiomyocytes.

, 2013
(a) Light and Fluorescent microscope images of adult human cardiomyocytes seeded onto different coatings, took after overnight incubation. (I) Light and Hoechst image for collagen 1 coating (0.125 µg/µl), (II) Light and Hoechst image for gelatine coating
Jenson Lim (295188), Mahendran Subramanian (440110), Jon Dobson (53892)   +2 more
core   +1 more source

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, EarlyView.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source

Microscale Generation of Cardiospheres Promotes Robust Enrichment of Cardiomyocytes Derived from Human Pluripotent Stem Cells

Stem Cell Reports, 2014
Cardiomyocytes derived from human pluripotent stem cells (hPSCs) are a promising cell source for regenerative medicine, disease modeling, and drug discovery, all of which require enriched cardiomyocytes, ideally ones with mature phenotypes.
Doan C. Nguyen, Tracy A. Hookway, Qingling Wu, Rajneesh Jha, Marcela K. Preininger, Xuemin Chen, Charles A. Easley, Paul Spearman, Shriprasad R. Deshpande, Kevin Maher, Mary B. Wagner, Todd C. McDevitt, Chunhui Xu   +12 more
doaj   +1 more source

NFYB Integrates Hormonal Signals into Tissue Allometry by Promoting Protein Biosynthesis

Advanced Science, EarlyView.
In the American cockroach, NFYB acts as a spatiotemporin that translates distinct hormonal cues into tissue‐specific allometry. Juvenile hormone activates NFYB in the early fat body, while 20‐hydroxyecdysone induces it in late wing pads. NFYB then promotes protein biosynthesis via core translational machinery, driving differential growth across the ...
Fangfang Liu, Shiming Zhu, Sishi Xia, Xiaoshuai Zhang, Qin Li, Zhanquan Zeng, Yuqing Liu, Wanyin Liang, Guanyu Zhou, Erxia Du, Suning Liu, Sheng Li   +11 more
wiley   +1 more source

A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees

eLife, 2019
Despite anatomical similarities, there are differences in susceptibility to cardiovascular disease (CVD) between primates; humans are prone to myocardial ischemia, while chimpanzees are prone to myocardial fibrosis.
Michelle C Ward, Yoav Gilad
doaj   +1 more source

Differentiation of cardiomyocytes and generation of human engineered heart tissue

, 2017
Since the advent of the generation of human induced pluripotent stem cells (hiPSCs), numerous protocols have been developed to differentiate hiPSCs into cardiomyocytes and then subsequently assess their ability to recapitulate the properties of adult ...
Christiane Neuber, Rodriguez, Marita L., Eschenhagen, Thomas, Bärbel Ulmer, Umber Saleem, Letuffe-Breniere, David, Shibamiya, Aya, Elisabeth Krämer, Breckwoldt, Kaja, Mearini, Giulia, Aya Shibamiya, Marina C Reinsch, Sandra Laufer, Fuchs, Sigrid, Neuber, Christiane, Prondzynski, Maksymilian, Saleem, Umber, Sigrid Fuchs, Thomas Schulze, Maksymilian Prondzynski, Schulze, Thomas, Reinsch, Marina C., Mirja L Schulze, Birgit Klampe, Benzin, Anika, Dennis Schade, Werner, Tessa, Mannhardt, Ingra, Schulze, Mirja L., Hansen, Arne, Giulia Mearini, Arne Hansen, Ulmer, Baerbel, Kaja Breckwoldt, Tessa Werner, Klampe, Birgit, Thomas Eschenhagen, Kraemer, Elisabeth, Schade, Dennis, Anika Benzin, Marita L Rodriguez, Laufer, Sandra, David Letuffe-Brenière, Ingra Mannhardt   +43 more
core   +1 more source

Stretchable Microelectrode Arrays with Microneedles for Reliable Electrophysiological Recording of Human Heart and Brain Organoids

Advanced Science, EarlyView.
A stretchable 3D microelectrode array with microneedles (3D MN‐sMEA) enables stable, minimally destructive electrophysiological monitoring of 3D organoids. The wafer‐level stud‐bump bonding process facilitates high‐fidelity recordings of heart and cerebral organoids.
Eunyoung Jang, Saewoon Shin, Seul‐Gi Lee, Kiup Kim, Yoojeong Kim, Jun Sun, Il‐Joo Cho, Joseph A. Gogos, Jong‐Chan Park, C‐Yoon Kim, Hyunjoo J. Lee   +10 more
wiley   +1 more source

Influence of continuous electrical stimulation on development of human cardiomyocytes from induced pluripotent stem cells [PDF]

, 2018
Regeneration of cardiac tissue remains an ideal approach to restore cardiac function after myocardial infarction. The ability of human induced pluripotent stem cells (iPSCs) to differentiate into bona fide cardiomyocytes also provides a platform for ...
Hernández, D, Millard, R, Pebay, A, Lim, S, Kong, A, Sivakumaran, P, Sheperd, R, Mitchell, G, Dusting, G   +8 more
core