Results 241 to 250 of about 113,516 (292)

The Effects of Angiotensin Receptor Neprilysin Inhibitor on Endoplasmic Reticulum Stress in Doxorubicin‐Mediated Cardiomyopathy‐Associated Heart Failure Model in Rats

Journal of Applied Toxicology, EarlyView.
ABSTRACT One of the most serious complications associated with the use of the chemotherapeutic agent doxorubicin (DOX) is cardiomyopathy. Although cardioprotective drugs such as angiotensin receptor‐neprilysin inhibitors (ARNI) are used to prevent cardiomyopathy in DOX patients, no studies have reported the relationship between ARNI and endoplasmic ...
Mert Unvan, Meryem İlkay Karagül, Hatice Oruç Demirbağ, Ebru Balli   +3 more
wiley   +1 more source

Maturation of human cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) on polycaprolactone and polyurethane nanofibrous mats. [PDF]

Sci Rep
Iwoń Z, Krogulec E, Tarnowska I, Łopianiak I, Wojasiński M, Dobrzyń A, Jastrzębska E.   +6 more
europepmc   +1 more source

Molecular Mechanism of the IRF1/NFE2L1‐DT/ALKBH5/Cx43 Axis in Radiation‐Induced Injury in Vascular Endothelial Cells Through Pyroptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li, Jia‐Wen Yang, Yong‐Rui Jia, Jie Zhang, Qiao Gou   +4 more
wiley   +1 more source

hsa-miR-548v controls the viscoelastic properties of human cardiomyocytes and improves their relaxation rates. [PDF]

JCI Insight
Vermersch E, Neuvendel S, Jouve C, Ruiz-Velasco A, Pereira C, Seguret M, Cattin-Messaoudi ME, Lotfi S, Dorval T, Berson P, Hulot JS.   +10 more
europepmc   +1 more source

METTL14 Regulates Myocardial Infarction Progression via m6A‐Dependent Modulation of OTUD1‐Mediated Deubiquitination of DUSP6

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Myocardial infarction (MI) is the most severe clinical manifestation of coronary artery diseases (CVD) and serves as a critical driver of sudden cardiac death and heart failure (HF). Its pathophysiology begins with the abrupt cessation of coronary blood flow, leading to severe ischemia and subsequent cardiomyocyte necrosis. This study aimed to
Cheng‐Cheng Wei, Ya‐Fang Shen, Jin‐Yu Zhang   +2 more
wiley   +1 more source

NRF2 upregulation by CDDO-Me protects AC16 human cardiomyocytes against doxorubicin-induced toxicity

Roberts JA, Batie M, Ponsford AH, Poh J, Hewitt BJ, Botfield HF, Hill LJ, Sanderson CM, Rocha S, Sharma P.   +9 more
europepmc   +1 more source

Correction: Huynh et al. Spike Protein Impairs Mitochondrial Function in Human Cardiomyocytes: Mechanisms Underlying Cardiac Injury in COVID-19. Cells 2023, 12, 877. [PDF]

Cells
Huynh TV, Rethi L, Lee TW, Higa S, Kao YH, Chen YJ.   +5 more
europepmc   +1 more source

Early Dapagliflozin and Melatonin Treatment Ameliorated LV Fibrosis via Suppressing TGF‐β1/Smads and Activating Nrf2‐ARE Signaling in MI Rodent

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study tested whether combined dapagliflozin (DAPA) and melatonin (Mel) therapy was superior to merely one for ameliorating the left ventricular (LV) fibrosis/remodeling and improving LV ejection fraction (LVEF) in rats after acute myocardial infarction (AMI). In vitro study demonstrated that DAPA treatment significantly suppressed the TGF‐
Jiunn‐Jye Sheu, Jui‐Ning Yeh, Han‐Tan Chai, John Y. Chiang, Chi‐Ruei Huang, Jun Guo, Hon‐Kan Yip   +6 more
wiley   +1 more source

Hypoxia-induced circRNAs encoded by PPARA are highly expressed in human cardiomyocytes and are potential clinical biomarkers of acute myocardial infarction. [PDF]

Eur J Med Res
Huang S, Wu Z, Zhou Y.
europepmc   +1 more source