Results 221 to 230 of about 103,809 (257)

Assessment of mitophagy in human iPSC-derived cardiomyocytes

Autophagy, 2022
Defective mitophagy contributes to normal aging and various neurodegenerative and cardiovascular diseases. The newly developed methodologies to visualize and quantify mitophagy allow for additional progress in defining the pathophysiological significance of mitophagy in various model organisms. However, current knowledge regarding mitophagy relevant to
Mingchong, Yang, Ji-Dong, Fu, Jizhong, Zou, Divya, Sridharan, Ming-Tao, Zhao, Harpreet, Singh, Judith, Krigman, Mahmood, Khan, Gang, Xin, Nuo, Sun   +9 more
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Human cardiomyocyte progenitor cell-derived cardiomyocytes display a maturated electrical phenotype

Journal of Molecular and Cellular Cardiology, 2010
Cardiomyocyte progenitor cells (CMPCs) can be isolated from the human heart and differentiated into cardiomyocytes in vitro. A comprehensive assessment of their electrical phenotype upon differentiation is essential to predict potential future applications of this cell source.
Boer, T.P. de, Veen, T.A.B. van, Jonsson, M.K.B., Kok, B.G.J.M., Metz, C.H.G., Sluijter, J.P.G., Doevendans, P.A., Bakker, J.M.T. de, Goumans, M.J., Heyden, M.A.G. van der   +9 more
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Patterning the heart, a template for human cardiomyocyte development

Developmental Dynamics, 2006
AbstractAlthough in mice, the dynamics of gene expression during heart development is well characterized, information on humans is scarce due to the limited availability of material. Here, we analyzed the transcriptional distribution of Mlc‐2a, Mlc‐1v, Mlc‐2v, and atrial natriuretic factor (ANF) in human embryonic hearts between 7 and 18 weeks of ...
Susana M, Chuva de Sousa Lopes, Rutger J, Hassink, Alie, Feijen, Marga A, van Rooijen, Pieter A, Doevendans, Leon, Tertoolen, Aart, Brutel de la Rivière, Christine L, Mummery   +7 more
openaire   +2 more sources

Variability of the cardiomyocyte ploidy in normal human hearts

Virchows Archiv B Cell Pathology Including Molecular Pathology, 1992
We have performed cytophotometry for DNA in isolated myocytes of the left ventricle from 16 men, aged 19-39 years, who died from various non-cardiac or pulmonary causes. The mean ploidy of myocytes varied from 3.2-3.9 c to 6.6-7.3 c in different layers of the anterior wall of the left ventricle (where c is the haploid DNA content measured by ...
, Brodsky VYa, A L, Chernyaev, I A, Vasilyeva   +2 more
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Development of Cardiomyocytes from Human ES Cells

2003
Publisher Summary Cell transplantation is emerging as a novel strategy for myocardial regeneration, but it has been hampered by the lack of a source for human cardiomyocytes. Similarly, the lack of a human cardiomyocyte cell line has significantly limited a variety of experimental procedures.
Izhak, Kehat, Michal, Amit, Amira, Gepstein, Irit, Huber, Joseph, Itskovitz-Eldor, Lior, Gepstein   +5 more
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Cardiomyocytes from Human Embryonic Stem Cells

2006
Terminal heart failure is characterized by a significant loss of cardiac myocytes. Stem cells represent a possibility for replacing these lost myocytes but the question of which stem cells are most ideally suited for cell transplantation therapies is still being addressed.
R, Passier, C, Denning, C, Mummery
openaire   +2 more sources

Cardiomyocyte marker expression in a human lymphocyte cell line using mouse cardiomyocyte extract

Human Cell, 2011
Cell transplantation shows potential for the treatment of cardiac diseases. Embryonic stem cells, cord blood and mesenchymal stem cells have been suggested as sources for transplantation therapy. Because of some technical limitations with the use of stem cells, transdifferentiation of fully differentiated cells is a potentially useful alternative.
Zahra, Vojdani, Sima, Tavakolinejad, Tahereh, Talaei-Khozani, Tahereh, Esmaeilpour, Manuchehr, Rasooli   +4 more
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Postnatal cardiomyocyte growth and mitochondrial reorganization cause multiple changes in the proteome of human cardiomyocytes

Molecular BioSystems, 2013
Abstract Fetal (fCM) and adult cardiomyocytes (aCM) significantly differ from each other both by structure and biochemical properties. aCM own a higher mitochondrial mass compared to fCM due to increased energy demand and show a greater density and higher degree of structural organization of myofibrils.
Jaakko L O, Pohjoismäki, Marcus, Krüger, Natalie, Al-Furoukh, Anssi, Lagerstedt, Pekka J, Karhunen, Thomas, Braun   +5 more
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[The ploidy variability of human cardiomyocytes].

Biulleten' eksperimental'noi biologii i meditsiny, 1990
Unlike literature on ploidy of the human myocytes, DNA content and the number of nuclei have been revealed in the same cells. Besides, the cell ploidy were studied separately in the external, central and inner regions in the left ventricule. Considerable binucleation was revealed in normal and hypertrophic ventricles where 4c X2 was the modal cell ...
V Ia, Brodskiĭ, I A, Vasil'eva, N V, Panova, D S, Sarkisov, A M, Aref'eva   +4 more
openaire   +1 more source

Reprogramming of human keratinocytes into functional cardiomyocytes

Italian Journal of Anatomy and Embryology, 2015
Purpose. Induced pluripotent stem cells (iPS) can be generated by patients intro- ducing transcription factors that are highly expressed in embryonic stem (ES) cells into somatic cells. However, the various iPS cell lines are characterized by different properties such as differentiation efficiency and potential safety hazards.
Ghinassi, Barbara, D’Amico, Maria, Izzicupo, Pascal, Di Baldassarre, Angela   +3 more
openaire   +1 more source