Results 261 to 270 of about 113,516 (292)

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Calcium Homeostasis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes [PDF]

Stem Cell Reviews and Reports, 2011
Rationale: Cardiomyocytes generated from human induced pluripotent stem cells (hiPSCs) are suggested as the most promising candidate to replenish cardiomyocyte loss in regenerative medicine.
Yee-Ki Lee, Kwong-Man Ng, Yau-Chi Chan   +2 more
exaly   +2 more sources

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Measuring hypertrophy in neonatal rat primary cardiomyocytes and human iPSC-derived cardiomyocytes

Methods, 2022
In the heart, left ventricular hypertrophy is initially an adaptive mechanism that increases wall thickness to preserve normal cardiac output and function in the face of coronary artery disease or hypertension. Cardiac hypertrophy develops in response to pressure and volume overload but can also be seen in inherited cardiomyopathies.
Kyla, Bourque, Cara, Hawey, Jace, Jones-Tabah, Darlaine, Pétrin, Ryan D, Martin, Yi, Ling Sun, Terence E, Hébert   +6 more
openaire   +2 more sources

Isolation and Differentiation of Human Cardiomyocyte Progenitor Cells into Cardiomyocytes

2012
To date, there is no suitable in vitro model to study human adult cardiac cell biology. Here, we describe a method for efficient isolation and expansion of human cardiomyocyte progenitor cells (CMPCs) from cardiac surgical waste or, alternatively, from fetal heart tissue.
Anke M, Smits, Angelique A, van Oorschot, Marie-José, Goumans   +2 more
openaire   +4 more sources

The human adult cardiomyocyte phenotype

Cardiovascular Research, 2003
Determination of the phenotype of adult human atrial and ventricular myocytes based on gene expression and morphology.Atrial and ventricular cardiomyocytes were obtained from patients undergoing cardiac surgery using a modified isolation procedure. Myocytes were isolated and cultured with or without serum.
Bird, SD, Doevendans, PA, van Rooijen, MA, de la Riviere, AB, Hassink, RJ, Passier, R, Mummery, CL   +6 more
openaire   +3 more sources

Adult human cardiomyocyte mechanics in osteogenesis imperfecta

American Journal of Physiology-Heart and Circulatory Physiology, 2023
In a rare donation of a heart from an individual with osteogenesis imperfecta (OI), we explored cardiomyocyte (CM) adaptations to low stiffness. This represents the first assessment of cardiomyocyte mechanics in OI. The data reveal the hypercontractility of OI CMs with rapid rundown when exposed to acute stiffness challenges, extending our ...
Benjamin W. Lee, Matthew A. Caporizzo, Christina Y. Chen, Kenneth C. Bedi, Eliot G. Peyster, Benjamin L. Prosser, Kenneth B. Margulies, Alexia Vite   +7 more
openaire   +4 more sources

Assessment of mitophagy in human iPSC-derived cardiomyocytes

Autophagy, 2022
Defective mitophagy contributes to normal aging and various neurodegenerative and cardiovascular diseases. The newly developed methodologies to visualize and quantify mitophagy allow for additional progress in defining the pathophysiological significance of mitophagy in various model organisms. However, current knowledge regarding mitophagy relevant to
Mingchong, Yang, Ji-Dong, Fu, Jizhong, Zou, Divya, Sridharan, Ming-Tao, Zhao, Harpreet, Singh, Judith, Krigman, Mahmood, Khan, Gang, Xin, Nuo, Sun   +9 more
openaire   +2 more sources

Human cardiomyocyte progenitor cell-derived cardiomyocytes display a maturated electrical phenotype

Journal of Molecular and Cellular Cardiology, 2010
Cardiomyocyte progenitor cells (CMPCs) can be isolated from the human heart and differentiated into cardiomyocytes in vitro. A comprehensive assessment of their electrical phenotype upon differentiation is essential to predict potential future applications of this cell source.
Boer, T.P. de, Veen, T.A.B. van, Jonsson, M.K.B., Kok, B.G.J.M., Metz, C.H.G., Sluijter, J.P.G., Doevendans, P.A., Bakker, J.M.T. de, Goumans, M.J., Heyden, M.A.G. van der   +9 more
openaire   +4 more sources

Patterning the heart, a template for human cardiomyocyte development

Developmental Dynamics, 2006
AbstractAlthough in mice, the dynamics of gene expression during heart development is well characterized, information on humans is scarce due to the limited availability of material. Here, we analyzed the transcriptional distribution of Mlc‐2a, Mlc‐1v, Mlc‐2v, and atrial natriuretic factor (ANF) in human embryonic hearts between 7 and 18 weeks of ...
Susana M, Chuva de Sousa Lopes, Rutger J, Hassink, Alie, Feijen, Marga A, van Rooijen, Pieter A, Doevendans, Leon, Tertoolen, Aart, Brutel de la Rivière, Christine L, Mummery   +7 more
openaire   +2 more sources

Variability of the cardiomyocyte ploidy in normal human hearts

Virchows Archiv B Cell Pathology Including Molecular Pathology, 1992
We have performed cytophotometry for DNA in isolated myocytes of the left ventricle from 16 men, aged 19-39 years, who died from various non-cardiac or pulmonary causes. The mean ploidy of myocytes varied from 3.2-3.9 c to 6.6-7.3 c in different layers of the anterior wall of the left ventricle (where c is the haploid DNA content measured by ...
, Brodsky VYa, A L, Chernyaev, I A, Vasilyeva   +2 more
openaire   +2 more sources