Results 11 to 20 of about 8,385,867 (288)

Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion

Science Advances, 2021
Prefusion human cytomegalovirus glycoprotein B structure reveals the structural basis for membrane fusion. Human cytomegalovirus (HCMV) causes congenital disease with long-term morbidity.
Yuhang Liu, Kyle P. Heim, Y. Che, X. Chi, X. Qiu, Seungil Han, P. Dormitzer, Xinzhen Yang   +7 more
semanticscholar   +1 more source

Human Cytomegalovirus and Autoimmune Diseases: Where Are We?

Viruses, 2021
Human cytomegalovirus (HCMV) is a ubiquitous double-stranded DNA virus belonging to the β-subgroup of the herpesvirus family. After the initial infection, the virus establishes latency in poorly differentiated myeloid precursors from where it can ...
F. Gugliesi, Selina Pasquero, G. Griffante, S. Scutera, Camilla Albano, Sergio Fernando Castillo Pacheco, G. Riva, Valentina Dell’Oste, Matteo Biolatti   +8 more
semanticscholar   +1 more source

Clinical Diagnostic Testing for Human Cytomegalovirus Infections.

Journal of Infectious Diseases, 2020
Human cytomegalovirus (HCMV) infections are among the most common complications arising in transplant patients, elevating the risk of various complications including loss of graft and death.
R. Razonable, N. Inoue, Swetha Pinninti, S. Boppana, T. Lazzarotto, L. Gabrielli, G. Simonazzi, P. Pellett, D. S. Schmid   +8 more
semanticscholar   +1 more source

Temporal dynamics of protein complex formation and dissociation during human cytomegalovirus infection

Nature Communications, 2020
The co-evolution and co-existence of viral pathogens with their hosts for millions of years is reflected in dynamic virus-host protein-protein interactions (PPIs) that are intrinsic to the spread of infections.
Yutaka Hashimoto, Xinlei Sheng, Laura A Murray-Nerger, I. Cristea   +3 more
semanticscholar   +1 more source

Decoding Human Cytomegalovirus [PDF]

Science, 2012
Dissecting HCMV Gene Expression Most of us are infected with human cytomegalovirus (HCMV), but severe disease is almost always limited to immunocompromised individuals or newborn infants. The virus has a relatively large (∼240 kb) DNA genome and shows a complex pattern of gene transcription, hinting at a complex regulatory and ...
Hartmut Hengel, Annette Michalski, Ben Shen, Sheng-Xiong Huang, Marco Y. Hein, Jonathan S. Weissman, Ben Weisburd, Matthias Mann, Vu Thuy Khanh Le, Ming Ma, Shu-Bing Qian, Nicholas T. Ingolia, Noam Stern-Ginossar   +12 more
openaire   +3 more sources

The Status of Vaccine Development Against the Human Cytomegalovirus.

Journal of Infectious Diseases, 2020
Numerous candidate vaccines against cytomegalovirus (CMV) infection and disease are in development. Whereas the previous article [1] provides background and opinions about the issues relating to vaccination, this article provides specifics about the ...
S. Plotkin, Dai Wang, A. Oualim, D. Diamond, C. Kotton, S. Mossman, A. Carfi, D. Anderson, P. Dormitzer   +8 more
semanticscholar   +1 more source

A Review of Murine Cytomegalovirus as a Model for Human Cytomegalovirus Disease—Do Mice Lie?

International Journal of Molecular Sciences, 2020
Since murine cytomegalovirus (MCMV) was first described in 1954, it has been used to model human cytomegalovirus (HCMV) diseases. MCMV is a natural pathogen of mice that is present in wild mice populations and has been associated with diseases such as ...
M. Fisher, M. Lloyd
semanticscholar   +1 more source

Regarding human cytomegalovirus in neuroblastoma [PDF]

Cancer Medicine, 2014
Wolmer-Solberg et al., reported that six human neuroblastoma cell lines and the vast majority of clinical neuroblastoma samples contained HCMV DNA and expressed HCMV proteins. We could not replicate the data and therefore remain skeptical towards the prevalence of HCMV DNA in neuroblastomas.
Forslund, Ola, Holmquist Mengelbier, Linda, Gisselsson Nord, David   +2 more
openaire   +4 more sources

Interactions of Human Cytomegalovirus with Human Fibroblasts [PDF]

Journal of Bacteriology, 1966
Vonka, Vladimir(Baylor University College of Medicine, Houston, Tex.),and Matilda Benyesh-Melnick. Interactions of human cytomegalovirus with human fibroblasts. J. Bacteriol.91:213–220. 1966.—Virus attachment of human cytomegalovirus to human embryo lung fibroblasts was found to be temperature-independent, from 4 to 37 C.
Vladimir Vonka, Matilda Benyesh-Melnick
openaire   +3 more sources

Human Cytomegalovirus and Autoimmune Disease [PDF]

BioMed Research International, 2014
Human cytomegalovirus (HCMV) represents a prototypic pathogenic member of theβ-subgroup of the herpesvirus family. A range of HCMV features like its lytic replication in multiple tissues, the lifelong persistence through periods of latency and intermitting reactivation, the extraordinary large proteome, and extensive manipulation of adaptive and innate
Anne Halenius, Hartmut Hengel
openaire   +4 more sources