Results 11 to 20 of about 100,666 (169)

Thermoinactivation of Human Cytomegalovirus [PDF]

Journal of Bacteriology, 1966
Vonka, Vladimir (Baylor University College of Medicine, Houston, Tex.), and Matilda Benyesh-Melnick . Thermoinactivation of human cytomegalovirus. J. Bacteriol. 91: 221–226. 1966.—The inactivation at 4 and 37 C of several strains of human cytomegalovirus was studied.
Vladimı́r Vonka, Matilda Benyésh-Melnick   +1 more
openalex   +3 more sources

MicroRNAs expressed by human cytomegalovirus [PDF]

Virology Journal, 2020
Background MicroRNAs (miRNAs) are small non-coding RNAs about 22 nucleotides in length, which play an important role in gene regulation of both eukaryotes and viruses.
Lichen Zhang, Jiaqi Yu, Zhijun Liu
doaj   +4 more sources

Human cytomegalovirus and neonatal infection

Current Research in Microbial Sciences
Human cytomegalovirus is an ancient virus that has co-evolved with humans. It establishes a life-long infection in suspectable individuals for which there is no vaccination or cure.
Shelley M. Lawrence
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Control of human cytomegalovirus replication by liver resident natural killer cells

Nature Communications, 2023
Natural killer cells play important roles in the immune response to human cytomegalovirus infection. Here the authors implicate donor-derived liver resident natural killer cells in the control of human cytomegalovirus infection by analysis of perfusates ...
Calum Forrest, Thomas J. G. Chase, Antonia O. Cuff, Dionas Maroulis, Reza Motallebzadeh, Amir Gander, Brian Davidson, Paul Griffiths, Victoria Male, Matthew Reeves   +9 more
doaj   +1 more source

Decoding Human Cytomegalovirus [PDF]

Science, 2012
Dissecting HCMV Gene Expression Most of us are infected with human cytomegalovirus (HCMV), but severe disease is almost always limited to immunocompromised individuals or newborn infants. The virus has a relatively large (∼240 kb) DNA genome and shows a complex pattern of gene transcription, hinting at a complex regulatory and ...
Hartmut Hengel, Annette Michalski, Ben Shen, Sheng-Xiong Huang, Marco Y. Hein, Jonathan S. Weissman, Ben Weisburd, Matthias Mann, Vu Thuy Khanh Le, Ming Ma, Shu-Bing Qian, Nicholas T. Ingolia, Noam Stern-Ginossar   +12 more
openaire   +3 more sources

High-Risk Oncogenic Human Cytomegalovirus

Viruses, 2022
Human cytomegalovirus (HCMV) is a herpesvirus that infects between 40% and 95% of the population worldwide, usually without symptoms. The host immune response keeps the virus in a latent stage, although HCMV can reactivate in an inflammatory context ...
Georges Herbein
doaj   +1 more source

A fully human neutralizing monoclonal antibody targeting a highly conserved epitope of the human cytomegalovirus glycoprotein B.

PLoS ONE, 2023
Human cytomegalovirus causes severe diseases in children (by congenital infection) and immunocompromised patients. Treatment with antiviral agents, such as ganciclovir, is limited by their toxicity.
Miwa Okamoto, Rika Kurino, Ryu Miura, Kenzo Takada   +3 more
doaj   +1 more source

Human cytomegalovirus: taking the strain [PDF]

Medical Microbiology and Immunology, 2015
In celebrating the 60th anniversary of the first isolation of human cytomegalovirus (HCMV), we reflect on the merits and limitations of the viral strains currently being used to develop urgently needed treatments. HCMV research has been dependent for decades on the high-passage strains AD169 and Towne, heavily exploiting their capacity to replicate ...
Wilkinson, Gavin W. G., Davison, Andrew J., Tomasec, Peter, Fielding, Ceri A., Aicheler, Rebecca, Murrell, Isa, Seirafian, Sepher, Wang, Edward C. Y., Weekes, Michael, Lehner, Paul J., Wilkie, Gavin, Stanton, Richard J.   +11 more
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Sleepless latency of human cytomegalovirus [PDF]

Medical Microbiology and Immunology, 2015
As with all human herpesviruses, human cytomegalovirus (HCMV) persists for the lifetime of the host by establishing a latent infection, which is broken by periodic reactivation events. One site of HCMV latency is in the progenitor cells of the myeloid lineage such as CD34+ cells and their CD14+ derivatives. The development of experimental techniques to
Poole, Emma, Sinclair, John
openaire   +4 more sources

Human cytomegalovirus-specific CD4+ and CD8+ T-cell reconstitution in adult allogeneic hematopoietic stem cell transplant recipients and immune control of viral infection

Haematologica, 2008
Background Human cytomegalovirus infection is the most frequent viral complication in patients undergoing hematopoietic stem cell transplantation.
Daniele Lilleri, Chiara Fornara, Antonella Chiesa, Daniela Caldera, Emilio Paolo Alessandrino, Giuseppe Gerna   +5 more
doaj   +1 more source