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Human Cytomegalovirus microRNAs
2008MicroRNAs (miRNAs) are approximately 22 nucleotide RNAs that mediate the posttranscriptional regulation of gene expression. miRNAs regulate diverse cellular processes such as development, differentiation, cell cycling, apoptosis, and immune responses.
E. Yang +3 more
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Human cytomegalovirus infection and atherothrombosis
Journal of Thrombosis and Thrombolysis, 2011Vascular endothelium, as a key regulator of hemostasis, mediates vascular dilatation, prevents platelet adhesion, and inhibits thrombin generation. Endothelial dysfunction caused by acute or chronic inflammation, such as in atherosclerosis, creates a proinflammatory environment which supports leukocyte transmigration toward inflammatory sites, and at ...
Popović, Milan +5 more
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Human cytomegalovirus labyrinthitis
American Journal of Otolaryngology, 1990The purpose of this report is to present a review of the clinical and histopathologic findings in human cytomegalovirus (HCMV) labyrinthitis. Human cytomegalovirus infection was first recognized in its congenital disseminated form and, subsequently, in a subclinical form.
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Pneumonitis in human cytomegalovirus infection [PDF]
Current Infectious Disease Reports, 2006 Human cytomegalovirus (HCMV) is a beta herpes virus with a double stranded DNA genome of 240kbp. The virus is prevalent and establishes a latent infection in most adults. HCMV is an opportunistic pathogen for patients with impaired cellular immunity. HCMV pneumonia is a common presentation of HCMV disease in immunocompromised patients. The incidence of
Robert E. Siegel, Erik Langhoff
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Human Monoclonal Antibodies to Human Cytomegalovirus
The Journal of Infectious Diseases, 1989Human monoclonal antibodies (HMAbs) to human cytomegalovirus (HCMV) have been developed by using electric field-induced cell fusion of human B lymphocytes to the human-mouse cell line SBC-H20. By this procedure, multiple hybridomas have been produced that secrete IgG 1 HMAbs with distinct patterns of indirect immunofluorescence on HCMV-infected cells ...
Judy Rowe +6 more
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Therapies for human cytomegalovirus
Expert Opinion on Therapeutic Patents, 2007Human cytomegalovirus (HCMV) is a viral infection disseminated worldwide and ∼ 70% of the world population presents antibodies to CMV; usually the infection is asymptomatic in healthy individuals. However, the virus may be reactivated from latency if the host develops an immunodeficiency or is immunosuppressed by drugs.
V G Baracho +3 more
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Inactivation of human cytomegalovirus by phytohemagglutinin [PDF]
Archives of Virology, 1978 Human cytomegalovirus (CMV) was inactivated by treatment with phytohemagglutinin (PHA) in contrast to herpes simplex virus (HSV), which was not. Approximately 90% of infectivity was lost following exposure of CMV to PHA. Greater reduction of infectivity, more than 99%, was obtained following pretreatment of cells with PHA than by direct mixture of the ...
Linda Girvin +5 more
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Human Cytomegalovirus MiRNAs [PDF]
Future Virology, 2011 miRNAs are expressed by many organisms including viruses. The human cytomegalovirus (HCMV), which is a highly prevalent human herpesvirus, also expresses several miRNAs. Although HCMV-encoded miRNAs were discovered several years ago, only little was revealed with regard to their function and their contribution to the HCMV life cycle and viral ...
Daphna Nachmani, Ofer Mandelboim
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Human Herpesviruses: Cytomegalovirus
2014Cytomegalovirus (CMV) is significant for human health as a cause of birth defects and infections in immunocompromised patients. Congenital CMV infection is a leading cause of hearing loss and an important cause of mental retardation and cerebral palsy. CMV is a common opportunistic pathogen for immunocompromised patients, especially those with impaired
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Defective virions of human cytomegalovirus
Virology, 1979Abstract Passage of human cytomegalovirus at high multiplicity of infection generated defective virus particles which banded in CsCI at a lower buoyant density than standard virus. The DNA from defective virions banded at a lower buoyant density in CsCl than standard DNA and sedimented in sucrose gradients similar to standard DNA.
Michele L. Ramirez +3 more
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