Results 41 to 50 of about 8,385,867 (288)

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

Paroxysmal Dyskinesias Secondary to HHV‐6A Encephalitis: The First Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paroxysmal dyskinesias encompasses a spectrum of conditions marked by intermittent involuntary movements, with paroxysmal kinesigenic dyskinesias being the most common phenotype. Central nervous system infection is a rare cause of paroxysmal dyskinesias.
Zhuoran Wang, Haiting Li, Xiaoping Du, Qiong Wang, Yating Zhang, Huifang Wang   +5 more
wiley   +1 more source

Cell Membrane Vesicle Camouflaged Artificial Cells

Advanced Functional Materials, EarlyView.
Artificial cells camouflaged with a cell membrane vesicle coating are able to assemble into synthetic aggregates that exhibit rudimentary communication capabilities. Additionally, when these artificial cells are equipped with antioxidant capabilities, they are able to protect the intracellular homeostasis in HepG2 cells present in semi‐synthetic ...
Paula De Dios Andres, Stefan Pendlmayr, Noga Gal, Cathrine Abild Meyer, Cecilie Ryberg, Olav Vestrheim, Noel Angelo Kalacas, Fatih Demir, Markus M. Rinschen, Karsten Haupt, Rajeshwar Prosad Mookerjee, Brigitte Städler   +11 more
wiley   +1 more source

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

Biofabrication of a Filtration Barrier by Integrating Electrospun Membranes and Flow in a Glomerular Co‐Culture

Advanced Healthcare Materials, EarlyView.
An ex vivo glomerular filtration barrier is engineered using electrospun, biomimetic membranes seeded with human glomerular cells. The model supports fenestrated endothelium and podocyte foot processes under flow, mimics size‐selective filtration, and enables disease modeling with hiPSC‐derived podocytes, offering a powerful platform for studying ...
Camilla Mussoni, Anna Rederer, Vladimir Stepanenko, Frank Würthner, Philipp Stahlhut, Jürgen Groll, Mario Schiffer, Taufiq Ahmad, Janina Müller‐Deile   +8 more
wiley   +1 more source

Engineering CRISPR System‐Based Bacterial Outer Membrane Vesicle Potentiates T Cell Immunity for Enhanced Cancer Immunotherapy

Advanced Materials, EarlyView.
This study develops a multifunctional CRISPR‐dCas9‐based OMV platform termed OMV‐C9I12, which facilitates the coexpression of CXCL9 and IL‐12 within tumor cells. This platform enhances T cell recruitment and activation, synergizes with anti‐PD‐1/PD‐L1 immunotherapy, and amplifies antitumor T cell immunity.
Hongjin Wang, Hengji Zhan, Bolin Pan, Leli Zeng, Zehua Chen, Sen Liu, Qiang Zhang, Xuwei Hong, Junlin Lu, Xinrou Lin, Xiao Zhao, Jiajian Lai, Kaiwen Jie, Ye Li, Jianmei Zhong, Shengmeng Peng, Siting Chen, Changhao Chen, Wenlong Zhong, Shaoxu Wu, Yihang Pan, Tianxin Lin, Xu Chen   +22 more
wiley   +1 more source

Mechanical Interactions Impact the Functions of Immune Cells and Their Application in Immunoengineering

Advanced Therapeutics, EarlyView.
This review covers the mechanical forces experienced by immune cells through cell–cell and cell–extracellular matrix interactions and how these forces influence their receptors and functions. These relationships between forces and cellular functions can be exploited using engineering techniques to modify the physical properties of materials for novel ...
Yu‐Chang Chen, Nghi M. Tran, Kyle H. Vining   +2 more
wiley   +1 more source

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

Advanced Science, EarlyView.
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang, Yousheng Wu, Xuanlin Su, Kaiwei Cai, Man Ke, Niu He, Huili Zhu, Zefeng Tan, Jielin Zhu, Wensheng He, Min Peng, Shiqing Zhang, Hongcheng Mai, Anding Xu, Dan Lu   +14 more
wiley   +1 more source

Inhibition of Human Cytomegalovirus by Rifampin

Journal of General Virology, 1975
Replication of human cytomegalovirus (CMV) was inhibited by 50 mug/ml of rifampin. Nevertheless, a number of functions of CMV were still expressed in the presence of rifampin, including early cell rounding, and the development of immuno-fluorescent antigen, haemadsorption antigen, complement-fixing antigen and precipitin antigens.
T. Furukawa, S. A. Plotkin, S. Tanaka
openaire   +3 more sources