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Stimulation of Human Dermal Fibroblasts with Interleukin 2
Journal of Burn Care & Rehabilitation, 1991The role of soluble inflammatory mediators in the wound healing process is under investigation. Interleukin 2 (IL2), an immune modulator produced by T lymphocytes, was tested in vitro for its effects on human diploid fibroblasts. Human diploid fibroblasts (1.0 x 10(4)) were incubated for 24 hours in Alpha minimal essential media (Gibco Laboratories ...
A, Abdullah, R L, McCauley, D N, Herndon
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Quantification of Single Human Dermal Fibroblast Contraction
Tissue Engineering, 1998Contraction forces produced by single, human dermal fibroblasts (HDF), cultured on deformable silicone substrata, were quantified using video microscopy and image analysis. Cell contraction causes deformation of the substrate, which appears as a series of surface wrinkles perpendicular to the long axis of the cell.
T R, Fray +3 more
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Characterization of Human Dermal Fibroblasts in Fabry Disease
Journal of Cellular Physiology, 2015Fabry disease (FD) is a hereditary X‐linked metabolic lysosomal storage disorder due to insufficient amounts or a complete lack of the lysosomal enzyme α‐galactosidase A (α‐GalA). The loss of α‐GalA activity leads to an abnormal accumulation of globotriaosylcerami (Gb3) in lysosomes and other cellular components of different tissues and cell types ...
LAKOMA, JARMILA +3 more
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Contractility of single human dermal myofibroblasts and fibroblasts
Cell Motility, 2002AbstractHuman dermal myofibroblasts, characterised by the expression of α‐smooth muscle actin, are part of the granulation tissue and implicated in the generation of contractile forces during normal wound healing and pathological contractures. We have compared the contractile properties of single human dermal fibroblasts and human dermal myofibroblasts
Louise K, Wrobel +5 more
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Antiphotoaging effect of chitooligosaccharides on human dermal fibroblasts
Photodermatology, Photoimmunology & Photomedicine, 2012SummaryBackground/PurposeIn the present study, the effect of 3–5 kDa chitooligosaccharide (COS) on homeostasis between the expression of collagen‐degrading matrix metalloproteinases (MMPs) and collagen synthesis was investigated using ultraviolet (UV)‐A irradiated dermal fibroblasts.MethodsUV protection imparted by 3–5 kDa COS was measured by examining
Jung-Ae, Kim +5 more
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Effects of Tamoxifen on Normal Human Dermal Fibroblasts
Archives of Facial Plastic Surgery, 2006Objective: To evaluate the effects of tamoxifen on the growth and autocrine growth factor production of human dermal fibroblasts from the face. Methods: In vitro study of normal adult dermal fibroblast cells developed from surgical ...
Mauro B, Ruffy +2 more
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Biomaterials, 2004
The ideal dermal matrix should be able to provide the right biological and physical environment to ensure homogenous cell and extracellular matrix (ECM) distribution, as well as the right size and morphology of the neo-tissue required. Four natural and synthetic 3D matrices were evaluated in vitro as dermal matrices, namely (1) equine collagen foam ...
Kee Woei Ng, D W Hutmacher
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The ideal dermal matrix should be able to provide the right biological and physical environment to ensure homogenous cell and extracellular matrix (ECM) distribution, as well as the right size and morphology of the neo-tissue required. Four natural and synthetic 3D matrices were evaluated in vitro as dermal matrices, namely (1) equine collagen foam ...
Kee Woei Ng, D W Hutmacher
exaly +4 more sources
A reappraisal of the biological effects of hyaluronan on human dermal fibroblast
Journal of Biomedical Materials Research Part A, 2008AbstractHyaluronan (HA) is a fundamental component of many biomaterials. Reports on the biological effects of HA are, however, both inconsistent and contradictory. This particularly refers to fibroblast contraction in the presence of high concentrations of HA.
Lin, Huang, Hua, Gu, Andrew, Burd
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Biological effects of cellular stretch on human dermal fibroblasts
Journal of Plastic, Reconstructive & Aesthetic Surgery, 2013Pathological scars are fibroproliferative skin disorders that are characterised by the accumulation of fibroblasts and collagens. It is increasingly understood that their development and progression may be related to local skin mechanics, such as stretching.
Chenyu, Huang +5 more
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Isolation and Culture of Human Dermal Fibroblasts
Dermal fibroblasts are the main cell type present in skin connective tissue (dermis). They are responsible for the synthesis of dermal extracellular matrix (ECM), providing mechanical stability for the dermal layer. In addition, fibroblasts interact with epidermal cells during hair development and in interfollicular skin cells through bidirectional ...Ziliani, Fabiana +2 more
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