Human epididymis protein 4 (HE4) in benign and malignant diseases [PDF]
Clinical Chemistry and Laboratory Medicine (CCLM), 2012 Abstract Background: Human epididymis protein 4 (HE4) is described as a useful new biomarker in ovarian cancer. As HE4 is neither tumor nor organ specific, we intensively investigated the occurrence of this protein in female and male patients with various benign and malignant diseases in order to avoid ...
Hertlein, Linda +9 more
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Advances of Human Epididymis Protein 4 in Lung Cancer
Chinese Journal of Lung Cancer, 2015 Human epididymis 4 (HE4) belongs to whey acidic 4-disulfide center protein family. It has the characteristics of inhibiting trypsin and high expression in the serum or malignant pleural effusion of patients with lung cancer.
Qing MA, Qian WANG, Diansheng ZHONG
doaj +3 more sources
Human epididymis protein-4 (HE-4): a novel cross-class protease inhibitor. [PDF]
PLoS ONE, 2012 Epididymal proteins represent the factors necessary for maturation of sperm and play a crucial role in sperm maturation. HE-4, an epididymal protein, is a member of whey acidic protein four-disulfide core (WFDC) family with no known function.
Nirmal Chhikara +5 more
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Serum Human Epididymis Protein 4 is a Potential Biomarker for Early Chronic Kidney Disease in an Obese Population [Retraction] [PDF]
Diabetes, Metabolic Syndrome and Obesity, 2021 Tan S, Zeng Y, Kuang S, Li J. Diabetes Metab Syndr Obes. 2021;14:1601–1608. The Editor and Publisher of Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy wish to retract the published article.
Tan S, Zeng Y, Kuang S, Li J
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The Role of Human Epididymis Protein 4 in the Diagnosis and Prognosis of Diseases: An Umbrella Review of Systematic Reviews and Meta-Analyses of Observational Studies [PDF]
Frontiers in Medicine, 2022 BackgroundThe application of human epididymis protein 4 (HE4) in diverse health diseases, especially in cancers, has been extensively studied in recent decades.
Ming-Li Sun +16 more
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Evaluation of follow-up observation using human epididymis protein 4, a tumor marker, in patients with ovarian cancer [PDF]
Obstetrics & Gynecology Science, 2023 Objective We evaluated the usefulness of human epididymis protein 4 (HE4), a tumor marker, during and after treatment in patients with ovarian cancer (OC).
Masaya Uno +3 more
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Human Epididymis Protein 4 Levels in Neonates with Respiratory Disorder. [PDF]
Biomed Res Int, 2020 Introduction. Transient tachypnea of the newborn (TTN) is one of the most common causes of respiratory distress in the full‐term neonates. The diagnosis of TTN in early postnatal period remains problematic for clinicians, and unfortunately, there exist no reliable diagnostic tests for TTN.
Surmiak P, Szymkowiak M, Baumert M.
europepmc +5 more sources
Diagnostic role of urine human epididymis protein 4 in ovarian cancer. [PDF]
Biochem Med (Zagreb)Ovarian cancer is the 8th most common malignancy in women and the deadliest gynecological cancer. Due to the non-specific symptoms and the lack of effective diagnostic methods, late diagnosis remains the main barrier for improving the poor prognosis.
Hanžek A, Siatka C, Duc AE.
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Elevated level of serum human epididymis protein 4 (HE4) predicts disease severity and mortality in COVID-19 pneumonia [PDF]
BMC Pulmonary Medicine, 2023 Background We retrospectively analyzed serum level of human epididymis protein 4 (HE4) as a pulmonary inflammatory biomarker in patients with COVID-19 pneumonia in association with disease severity and outcome.
Renáta Sütő +10 more
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Human epididymis protein 4, a novel potential biomarker for diagnostic and prognosis monitoring of lung cancer [PDF]
The Clinical Respiratory JournalObjective This study aimed to explore the application value of human epididymis protein 4 (HE4) in diagnosing and monitoring the prognosis of lung cancer.
Tingting Zhang +4 more
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