Results 41 to 50 of about 31,425 (209)

Expression of a catalytically inactive mutant form of glutathione peroxidase 4 (Gpx4) confers a dominant-negative effect in male fertility. [PDF]

, 2015
The selenoenzyme Gpx4 is essential for early embryogenesis and cell viability for its unique function to prevent phospholipid oxidation. Recently, the cytosolic form of Gpx4 was identified as an upstream regulator of a novel form of non-apoptotic cell ...
Aichler, M, Angeli, Jp, Buday, K, Conrad, M., Doll, S, Hoffard, N, Ingold, I, Roveri, Antonella, Tasdemir, A, Ursini, Fulvio, Walch, A, Wurst, W, Yefremova, E   +12 more
core   +1 more source

Current clinical application of serum biomarkers to detect and monitor ovarian cancer – update

Menopause Review, 2022
In recent decades many potential serum biomarkers have been assessed in the diagnosis of ovarian cancer. Except cancer antigen 125 (CA125) and human epididymis protein 4 (HE4), none of them have been applied to everyday clinical practice.
Łukasz Janas, Ewa Kalinka, Marek Nowak
doaj   +1 more source

The fabrication of magnetic particle-based chemiluminescence immunoassay for human epididymis protein-4 detection in ovarian cancer

Biochemistry and Biophysics Reports, 2018
The magnetic particles have a significant influence on the immunoassay detection and cancer therapy. Herein, the chemiluminescence immunoassay combined with the magnetic particles (MPCLIA) was presented for the clinical determination and analysis of ...
Xiaoling Fu, Yangyang Liu, Ruiyun Qiu, Mohamed F. Foda, Yong Zhang, Tao Wang, Jinshan Li   +6 more
doaj   +1 more source

HE4 in the Diagnostic Approach of Endometrial Cancer in Patients with Postmenopausal Bleeding, the METRODEC Protocol: Protocol for a Multicenter Prospective Study

Diagnostics, 2021
Background: Endometrial cancer is the most common pelvic gynecological cancer in France. The most frequent symptom is post-menopausal bleeding and is one of the primary reasons for consultation in gynecological emergencies. The treatment is very codified
Manon Degez, Hélène Caillon, Anne Chauviré-Drouard, Maxime Leroy, David Lair, Norbert Winer, Thibault Thubert, Pauline Le Floch, Valérie Desroys du Roure, Mélanie Randet, Guillaume Ducarme, Vincent Dochez   +11 more
doaj   +1 more source

Role of Human Epididymis Protein 4 in Tumour Angiogenesis

, 2023
HE4 is a secretory protein. It is expressed in reproductive tract and respiratory epithelium in normal individuals. Serum level of HE4 is raised in various solid cancers that give us an advantage to use it as a diagnostic and prognostic biomarker. It is an established biomarker of epithelial ovarian cancer [EOC].
Harshita Dubey, Mansi Modi, Saransh Verma, Ruchi Sinha, Harsh Goel, Amar Ranjan, Pranay Tanwar, Anita Chopra, Ekta Rahul, Lawanya Ranjan, Neeraj Verma, D Chauhan, Rani Kumari Mahkam, Utkarsh Dubey   +13 more
openaire   +1 more source

Identification of a novel human E-Cadherin splice variant andassessment of its effects upon EMT-related events [PDF]

, 2018
Epithelial Cadherin (E-cadherin) is involved in calcium-dependent cell-cell adhesion and signal transduction. The E-cadherin decrease/loss is a hallmark of Epithelial to Mesenchymal Transition (EMT), a key event in tumor progression.
Besso, María José, Furlong, Laura Ines, Giustina, Silvina, Lapyckyj, Lara, Marin Briggiler, Clara Isabel, Matos, María Laura, Mencucci, Maria Victoria, Rosso, Marina, Vazquez, Monica Hebe   +8 more
core   +1 more source

Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis [PDF]

Nature Medicine, 2013
The functional contribution of myofibroblasts in fibrosis is not well understood. Using a new genetic mouse model to track and isolate myofibroblasts, we performed gene expression profiling followed by biological validation to identify HE4 (encoding human epididymis protein 4, also known as WAP 4-disulfide core domain-2 or Wfdc2) as the most ...
LeBleu, Valerie S., Teng, Yingqi, O'Connell, Joyce T., Charytan, David M., Mueller, Georg Anton, Mueller, Claudia A., Sugimoto, Hikaru, Kalluri, Raghu   +7 more
openaire   +3 more sources

Non-Coding RNA Sequencing of Equine Endometrium During Maternal Recognition of Pregnancy. [PDF]

, 2019
Maternal recognition of pregnancy (MRP) in the mare is not well defined. In a non-pregnant mare, prostaglandin F2α (PGF) is released on day 14 post-ovulation (PO) to cause luteal regression, resulting in loss of progesterone production. Equine MRP occurs
Bouma, Gerrit J, Bruemmer, Jason E, Cameron, Ashley D, Canovas, Angela, Coleman, Stephen J, Hess, Ann M, Islas-Trejo, Alma D, Kalbfleisch, Ted, Klohonatz, Kristin M, Medrano, Juan F, Reed, Kailee J   +10 more
core   +1 more source

Ninety-day oral toxicity studies on two genetically modified maize MON810 varieties in Wistar Han RCC rats (EU 7th Framework Programme project GRACE) [PDF]

, 2014
The GMO Risk Assessment and Communication of Evidence (GRACE; www.grace-fp7.eu) project is funded by the European Commission within the 7th Framework Programme.
Ambrušová, Katarína, Bartušová, Mária, Einspanier, Ralf, Hanisch, Carlos, Kebis, Anton, Kovrižnych, Jevgenij, Krivošíková, Zora, Kuricová, Miroslava [u.v.m.], Sharbati, Jutta, Zeljenková, Dagmar   +9 more
core   +1 more source

Fabrication of a Highly Sensitive Electrochemical Immunosensor for Human Epididymis Protein 4 (HE4) Detection

International Journal of Electrochemical Science, 2018
Diagnostics of ovarian cancer can be achieved by detecting the level of human epididymis protein 4 (HE4). The present study proposed the preparation of a biosensor based on a nitrogen-doped graphene/gold nanoparticle (AuNP)/fluorine-doped tin oxide (FTO)
Jian Qu, Feng Yu
doaj   +1 more source