Results 101 to 110 of about 4,477 (231)

Adenoviral-delivered HE4-HSV-tk sensitizes ovarian cancer cells to ganciclovir [PDF]

, 2013
Ovarian cancer (OC) is most often contained within the peritoneal cavity, making it an ideal disease for adenoviral-delivered gene therapies. In effort to develop a safe and effective gene therapy for OC, we created a replication deficient adenovirus ...
Hunsaker, Joseph, Miller, David F., Nephew, Kenneth P., Rawlinson, Jennifer W., Vaden, Kiara   +4 more
core  

FLOT1 Is a Novel Serum Biomarker of Ovarian Cancer Targeted by N6‐methyladenosine Modification Inhibition

Cell Biology International, Volume 49, Issue 6, Page 674-691, June 2025.
ABSTRACT Ovarian cancer (OC) is a deadly disease and lacks a precise marker for diagnosis worldwide. Our previous work has shown the overexpression of flotillin‐1 (FLOT1) in OC tissue. To improve diagnostic sensitivity and accuracy, we evaluated the serum level of FLOT1 in OC patients and found that the serum concentration of FLOT1 as well as CA125 was
Bin Guan, Qi Lu, Junyu Chen, Jingyi Fang, Zhenyu Liu, Wei Li, Lingyun Zhang, Guoxiong Xu   +7 more
wiley   +1 more source

Screening for gynecological cancers [PDF]

, 2016
An estimated 17% of all new cancers in women worldwide are due to cancers of the cervix, the ovary and the uterus. Together, these cancers account for 14.6% of all female cancer deaths.
Kalsi, JK, Manchanda, R, Menon, U
core   +1 more source

Performance of Liquid Biopsy‐Based Multi‐Omics Biomarkers for Early Detection of Gynecological Malignancies: A Prospective Study (PERCEIVE‐I)

Advanced Science, Volume 12, Issue 20, May 29, 2025.
Following a comparative analysis of omics‐based cancer detection models, a novel liquid biopsy‐based multi‐omics combined model is developed for the early detection of gynecological malignancies. By integrating cell‐free DNA methylation and tumor protein markers, the combined model demonstrates high specificity and sensitivity and is uniquely designed ...
Zheng Feng, Huijuan Ge, Jingshu Wang, Yanan Wang, Xiaoran Sun, Bo Yang, Siyu Cao, Chenlian Quan, Qinhao Guo, Yusheng Han, Feidie Duan, Fang liu, Jing Zhao, Guoqiang Wang, Yuzi Zhang, Shangli Cai, Xiaohua Wu, Hao Wen   +17 more
wiley   +1 more source

HE4 overexpression decreases pancreatic cancer Capan-1 cell sensitivity to paclitaxel via cell cycle regulation

Cancer Cell International, 2020
Background Paclitaxel is a first-line chemotherapy drug for pancreatic, ovarian, endometrial cancers and other malignancies. However, its efficacy is often compromised by decreased cell sensitivity or the development of resistance.
Fengbiao Guo, Jinping Li, Yaozhi Qi, Jianqing Hou, Haibin Chen, Shi-Wen Jiang   +5 more
doaj   +1 more source

Human epididymis protein 4 aggravates airway inflammation and remodeling in chronic obstructive pulmonary disease

Respiratory Research, 2022
Background Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by chronic inflammation and airway remodeling. Human epididymis protein 4 (HE4) plays a critical role in various inflammatory or fibrotic diseases.
Yuan Zhan, Jinkun Chen, Jixing Wu, Yiya Gu, Qian Huang, Zhesong Deng, Shanshan Chen, Xiaojie Wu, Yongman Lv, Zhilin Zeng, Jungang Xie   +10 more
doaj   +1 more source

Immunohistochemical expression of human epididymis 4 in ovarian malignancy [PDF]

, 2019
Background: Ovarian malignancies has the highest mortality rate among all gynaecological malignancies. Surface epithelial tumors form two thirds of all ovarian neoplasm and 90% of all ovarian cancers are surface epithelial carcinomas.
Das, Chhanda, Kamilya, Gourishankar, Nahar, Begum Afrin, Saha, Rama   +3 more
core   +2 more sources

The biomarker HE4 (WFDC2) promotes a pro-angiogenic and immunosuppressive tumor microenvironment via regulation of STAT3 target genes [PDF]

, 2020
© 2020, The Author(s). Epithelial ovarian cancer (EOC) is a highly lethal gynecologic malignancy arising from the fallopian tubes that has a high rate of chemoresistant recurrence and low five-year survival rate. The ovarian cancer biomarker HE4 is known
+3 additional authors, Beffa, L., Borgstadt, A. D., Emerson, J. B., Hovanesian, V., James, N. E., Oliver, M. T., Ribeiro, J. R., Rowswell-Turner, R., Singh, R. K., Urh, A.   +10 more
core   +2 more sources

Detection of Estrogen Receptor Status in Breast Cancer Cytology Samples by an Optical Nanosensor

Advanced NanoBiomed Research, Volume 5, Issue 1, January 2025.
Single‐walled carbon nanotube (SWCNT)‐based optical sensors are designed to detect the presence of the estrogen receptor on the surface of breast cancer cells. The engineered sensor is benchmarked in vitro using recombinant protein and immortalized breast cancer cell lines.
Pooja V. Gaikwad, Nazifa Rahman, Pratyusha Ghosh, Dianna L. Ng, Ryan M. Williams   +4 more
wiley   +1 more source

NF-κb e IKK asociadas con baja respuesta al tratamiento con compuestos de platino en cáncer epitelial de ovario [PDF]

, 2014
El cáncer de ovario representa la octava neoplasia más recurrente en las mujeres y es el segundo cáncer ginecológico más común, siendo éste el responsable de aproximadamente 140.000 muertes al año en todo el mundo.
HERNANDEZ NAVARRO, MARIA DOLORES, HERNANDEZ NAVARRO, MARIA DOLORES, MENDIETA ZERON, HUGO, MENDIETA ZERON, HUGO, SANTILLAN BENITEZ, JONNATHAN GUADALUPE, SANTILLAN BENITEZ, JONNATHAN GUADALUPE, SARMIENTO SALINAS, FABIOLA LILI, SARMIENTO SALINAS, FABIOLA LILI   +7 more
core   +1 more source