Results 181 to 190 of about 4,477 (231)

Role of human epididymis protein 4 (HE4) in detecting recurrence in CA125 negative ovarian cancer patients

International Journal of Gynecological Cancer, 2019
Objective There are no current guidelines regarding evaluation of patients with normal CA125 at initial diagnosis during routine surveillance after completion of treatment.
F. Plotti, F. Guzzo, T. Schiró, C. Terranova, C. De Cicco Nardone, R. Montera, D. Luvero, G. Scaletta, Salvatore Lopez, S. Capriglione, P. Benedetti Panici, R. Angioli   +11 more
semanticscholar   +3 more sources

Human Epididymis Protein 4 (HE4)

Zentralblatt für Arbeitsmedizin, Arbeitsschutz und Ergonomie, 2018
N. Zulauf, M. Bendels, Jan Bauer, Markus Braun, G. Volante, G. Oremek, D. Groneberg, D. Brüggmann   +7 more
semanticscholar   +2 more sources

Human epididymis protein 4 (HE4) is a novel immunohistochemical marker of neuroendocrine differentiation

Virchows Archiv, 2022
Human epididymis protein 4 (HE4) is originally described as an epididymis specific protein and now clinically used as a serum marker for ovarian carcinoma. However, the expression of HE4 in neuroendocrine neoplasms (NENs) has not been studied. By immunohistochemistry, the expressions of HE4 in 94 normal tissues and 484 NENs which included 242 well ...
W. Su, Kun Yang, Huifeng Jiang, Haiyun Song, Kun Feng, Qiuyao Li   +5 more
semanticscholar   +3 more sources

Human Epididymis Protein 4 (HE4) as a Serum Tumor Biomarker in Patients With Ovarian Carcinoma

International Journal of Gynecological Cancer, 2011
Ovarian cancer remains a leading cause of death from gynecological malignancy. Early diagnosis is the most important determinant of survival. For more than 25 years, cancer antigen 125 (CA 125) has been the criterion standard biomarker for the diagnosis and management of women with epithelial ovarian cancer.
X. Chang, X. Ye, Li Dong, Hong-yan Cheng, Ye-xia Cheng, Li-Rong Zhu, Q. Liao, Yang Zhao, Li Tian, T. Fu, Junchen Chen, H. Cui   +11 more
semanticscholar   +3 more sources

Diagnostic Value of Serum Human Epididymis Protein 4 (HE4) in Ovarian Carcinoma: A Systematic Review and Meta-Analysis

International Journal of Gynecological Cancer, 2012
Li Wu, Z. Dai, Yong Qian, Yan Shi, Feng Liu, Chen Yang   +5 more
semanticscholar   +2 more sources

Human epididymis protein 4 (HE4) and ovarian cancer prognosis.

Gynecologic Oncology, 2012
A cohort study was conducted to evaluate whether preoperative plasma HE4 levels could predict the occurrence of death (primary endpoint) and progression (secondary endpoint) in women with ovarian cancer (OC).Between 1998 and 2006, we recruited 136 women newly diagnosed with OC of any FIGO stage at the University Hospital, CHUQ-L'Hôtel-Dieu de Québec ...
D. Trudel, B. Têtu, J. Grégoire, M. Plante, M. Renaud, D. Bachvarov, P. Douville, I. Bairati   +7 more
semanticscholar   +3 more sources

Human Epididymis Protein 4 (HE4) in Patients with Small-Cell Lung Cancer.

Clinical Laboratory, 2016
The aim of the present study was to compare the diagnostic utility of HE4 with NSE, ProGRP, CYFRA 21-1, CEA, and CA 125 and evaluate their prognostic value in patients with small-cell lung cancer (SCLC).HE4, ProGRP, NSE, CYFRA 21-1, CEA, and CA 125 assays were performed in 63 patients with smallcell lung cancer (limited disease (LD) - 41, extensive ...
Ewa Wójcik, J. Tarapacz, U. Rychlik, Z. Stasik, B. Sas-Korczyńska, P. Skotnicki, J. Kulpa   +6 more
semanticscholar   +3 more sources

Human epididymis protein 4 (HE4) plays a key role in ovarian cancer cell adhesion and motility.

Biochemical and Biophysical Research Communications, 2012
Human epididymis protein 4 (HE4) is a novel and specific biomarker for epithelial ovarian cancer (EOC). We previously demonstrated that serum HE4 levels were significantly elevated in the majority of EOC patients but not in subjects with benign disease or healthy controls. However, the precise mechanism of HE4 protein function is unknown. In this study,
R. Lu, Xinghui Sun, Ran Xiao, Lei Zhou, Xiang Gao, Lin Guo   +5 more
semanticscholar   +3 more sources

Comparison of Serum Human Epididymis Protein 4 (HE4) Levels in Breast Cancer Patients and Healthy Individuals

Indian Journal of Gynecologic Oncology, 2021
Human Epididymis Protein 4 (HE4) is one of serum biomarkers that recently reported in gynecological cancers, including breast cancer. This study aimed to compare serum HE4 levels in breast cancer patients and healthy individuals. This cross-sectional study examined serum HE4 levels in 42 patients and 36 healthy women in 2019.
Z. Honarvar, Behjat Kalantari Khandani, Mohaddeseh Nazari, Fatemeh Karami Robati   +3 more
semanticscholar   +2 more sources

Sensitive Detection of the Human Epididymis Protein-4 (HE4) Ovarian Cancer Biomarker through a Sandwich-Type Immunoassay Method with Laser-Induced Breakdown Spectroscopy.

Bioconjugate chemistry, 2023
Detection of cancer before the appearance of any symptoms is crucial for successful treatment. Early detection is, however, very challenging, particularly for the types of cancer with few or no symptoms at early stages, such as epithelial ovarian cancer (
R. Karunanithy, Suthakaran Ratnasingam, Torrey E Holland, P. Sivakumar   +3 more
semanticscholar   +1 more source