Results 11 to 20 of about 4,477 (231)

Diagnostic Performance of Serum Human Epididymis Protein 4 (HE4) for Prediction of Malignancy in Ovarian Masses [PDF]

Asian Pac J Cancer Prev, 2019
Background: Early diagnosis of ovarian cancer is essential for long term disease control and mortality reduction. This has been achieved using tumor markers like cancer antigen 125 (CA-125) which is elevated in malignant as well as non-malignant ...
Dewan R, Dewan A, Jindal M, Bhardawaj M.
europepmc   +5 more sources

Fabrication of a Highly Sensitive Electrochemical Immunosensor for Human Epididymis Protein 4 (HE4) Detection

International Journal of Electrochemical Science, 2018
Diagnostics of ovarian cancer can be achieved by detecting the level of human epididymis protein 4 (HE4). The present study proposed the preparation of a biosensor based on a nitrogen-doped graphene/gold nanoparticle (AuNP)/fluorine-doped tin oxide (FTO)
Jian Qu, Feng Yu
doaj   +3 more sources

Comparative Meta-Analysis of Carbohydrate Antigen 125 (CA125), Human Epididymis Protein 4 (HE4), and Diagnostic Indices (Risk of Malignancy Index (RMI) and Risk of Ovarian Malignancy Algorithm (ROMA)) for Pre-operative Detection of Ovarian Carcinoma. [PDF]

Cureus
Ovarian cancer remains a leading cause of gynecological cancer-related mortality, primarily due to late-stage diagnosis. Effective pre-operative differentiation between benign and malignant ovarian masses is crucial for improving patient outcomes.
Singh AK, Yadav P, Shukla M, Samaiya S, Singh S, Sorout S.   +5 more
europepmc   +2 more sources

The diagnostic accuracy of two human epididymis protein 4 (HE4) testing systems in combination with CA125 in the differential diagnosis of ovarian masses [PDF]

Clinical Chemistry and Laboratory Medicine, 2011
Background: Cancer antigen 125 (CA125) is the best known single tumor marker for ovarian cancer (OC). We investigated whether the additional information of the human epididymis protein 4 (HE4) improves diagnostic accuracy.
Burges, Alexander, Fuerst, Sophie, Hertlein, Linda, Hofmann, Karin, Kirschenhofer, Angela, Krocker, Katja, Lenhard, Miriam, Mayr, Doris, Nagel, Dorothea, Stieber, Petra   +9 more
core   +2 more sources

Human Epididymis Protein 4 (HE4) Reference Limits in Polish Population of Healthy Women, Pregnant Women, and Women with Benign Ovarian Tumors. [PDF]

Dis Markers, 2019
Objectives Defining precisely the normal range of HE4 protein is crucial for the proper interpretation of tumor marker results and for a more efficient diagnosis of ovarian malignancy. The aim of our study was to evaluate a reference limit of HE4 protein
Gasiorowska E, Kluz T, Lipski D, Warchoł W, Tykarski A, Nowak-Markwitz E.   +5 more
europepmc   +2 more sources

Clinical Significance of Cytokeratin 19-Fragments (CYFRA 21-1), Osteopontin (OPN) and Human Epididymis Protein 4 (HE4) in Pancreatic Adenocarcinoma [PDF]

Int J Mol Sci
Pancreatic cancer remains one of the most aggressive digestive neoplasms, especially due to late diagnosis. The aim of our study was to investigate cytokeratin-19 fragments (CYFRA 21-1), osteopontin (OPN), and human epididymis protein 4 (HE4) clinical ...
Dima A, Balaban D, Stanescu-Spinu I, Teodorescu A, Manucu G, Coman L, Dima A, Betianu C, Tanase M, Miricescu D, Jinga M, Carstoiu C.   +11 more
europepmc   +2 more sources

Adnexal mass with extremely high levels of CA-125 and CA19-9 but normal Human Epididymis Protein 4 (HE4) and Risk of Ovarian Malignancy Algorithm (ROMA): Endometriosis or ovarian malignancy? A case report. [PDF]

Int J Reprod Biomed, 2018
Background: It has been shown that Carbohydrate antigen (CA) 125 and CA 19-9 tumor markers are useful for diagnosis and follow up of ovarian carcinoma. Case: In this case, we reported the high level of CA-125 and CA 19-9 with large right ovarian intact ...
Khodaverdi S, Amini-Moghaddam S, Almassi Nokiani F, Hashemi N, Mohammad Beigi R.   +4 more
europepmc   +2 more sources

Human Epididymis Protein 4 (HE4) and Cancer Antigen 125 (CA125) for Prediction of Optimal Primary Surgery in Non-Mucinous Epithelial Ovarian Cancer. [PDF]

Asian Pac J Cancer Prev
Objective: To determine the relationship between pre-operative HE4 and CA125 levels in non-mucinous epithelial ovarian cancer cases (EOC) and outcomes of primary surgery for prediction of optimal surgery.
Promchit K, Oranratanaphan S.
europepmc   +2 more sources

Human Epididymis Secretory Protein 4 (HE4) Compromises Cytotoxic Mononuclear Cells via Inducing Dual Specificity Phosphatase 6 [PDF]

Frontiers in Pharmacology, 2019
While selective overexpression of serum clinical biomarker Human epididymis secretory protein 4 (HE4) is indicative of ovarian cancer tumorigenesis, much is still known about the mechanistic role of the HE4 gene or gene product. Here, we examine the role
Nicole E. James, Nicole E. James, Matthew T. Oliver, Jennifer R. Ribeiro, Evelyn Cantillo, Rachael B. Rowswell-Turner, Kyu-Kwang Kim, Clinton O. Chichester, Paul A. DiSilvestro, Richard G. Moore, Rakesh K. Singh, Rakesh K. Singh, Naohiro Yano, Naohiro Yano, Ting C. Zhao   +14 more
doaj   +4 more sources

Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas.

Cancer Research, 2005
Among the genes most commonly identified in gene expression profiles of epithelial ovarian carcinomas (EOC) is the gene for human epididymis protein 4 (HE4).
R. Drapkin, H. H. von Horsten, Yafang Lin, S. Mok, C. Crum, W. Welch, J. Hecht   +6 more
semanticscholar   +3 more sources