Results 61 to 70 of about 4,477 (231)

An SPRi Biosensor for Determination of the Ovarian Cancer Marker HE4 in Human Plasma

Sensors, 2021
Human epididymis protein 4 (HE4) is an ovarian cancer marker. Various cut-off values of the marker in blood are recommended, depending on the method used for its determination.
Beata Szymanska, Zenon Lukaszewski, Beata Zelazowska-Rutkowska, Kinga Hermanowicz-Szamatowicz, Ewa Gorodkiewicz   +4 more
doaj   +1 more source

Epigenetics in ovarian cancer: premise, properties, and perspectives. [PDF]

, 2018
Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers. Both late tumor diagnosis and tolerance to available chemical therapy increase patient mortality.
Huang, Shuang, Lau, Bonnie, Lau, Wayne Bond, Tang, Kexin, Wang, Hongjing, Wang, Wei, Wang, Xin, Wei, Yuquan, Xu, Lian, Yang, Qilian, Yang, Yuqing, Yang, Zhengnan, Yi, Tao, Zhao, Linjie, Zhao, Xia, Zhou, Nianxin, Zhou, Shengtao   +16 more
core   +2 more sources

Serum HE4: An Independent Prognostic Factor in Non-Small Cell Lung Cancer. [PDF]

PLoS ONE, 2015
Human epididymis secretory protein 4 (HE4) is a secreted glycosylated protein encoded by the WAP four-disulfide core domain 2 (WFDC2) gene, located on a chromosome 20 segment that is frequently amplified in many cancers.
Pierre-Jean Lamy, Carine Plassot, Jean-Louis Pujol   +2 more
doaj   +1 more source

Comparison of two immunoassays for the measurement of serum HE4 for ovarian cancer

Practical Laboratory Medicine, 2021
Introduction: The use of Human Epididymis Protein 4 (HE4) as a biomarker for ovarian cancer is gaining traction, providing the impetus for development of a high throughput automated HE4 assay that is comparable to the conventional manual enzyme ...
Chloe E. Barr, Garth Funston, Luke T.A. Mounce, Phillip W. Pemberton, Jonathon D. Howe, Emma J. Crosbie   +5 more
doaj   +1 more source

WAP four-disulfide core domain protein 2 promotes metastasis of human ovarian cancer by regulation of metastasis-associated genes. [PDF]

, 2017
BACKGROUND: WAP four-disulfide core domain protein 2 (WFDC2) shows a tumor-restricted upregulated pattern of expression in ovarian cancer. METHODS: In this study, we evaluated the role of WFCD2 in tumor mobility, invasion and metastasis of ovarian cancer
A Noel, A Scott, B-D Choi, D Bouchard, D Zhang, DSPAR Tan, E Hoskins, H Wei, HMD Naora, J Jalkanen, JA Caruso, JD Cheng, Ji-Liang Li, K Sakata, L Hertlein, Liping Huang, LYX Zhou, MHCL Shao, Ming Li, N Devoogdt, PA Henriksen, R Angioli, R-F Wang, RG Moore, SL Zou, Suihai Wang, T Nukiwa, Tiancai Liu, U Westin, V Manolov, Y Chen, Yao Chen, Yingsong Wu   +32 more
core   +1 more source

HE4 as a Biomarker for Endometrial Cancer [PDF]

, 2021
There are currently no blood biomarkers in routine clinical use in endometrial carcinoma (EC). Human epididymis protein 4 (HE4) is a glycoprotein that is overexpressed in the serum of patients with EC, making it a good candidate for use as a diagnostic ...
Barr, Chloe E., Behrouzi, Roya, Crosbie, Emma   +2 more
core   +1 more source

Overexpression of HE4 (human epididymis protein 4) enhances proliferation, invasion and metastasis of ovarian cancer

Oncotarget, 2015
Overexpression of Human epididymis protein 4 (HE4) related with a role in ovarian cancer tumorigenesis while little is known about the molecular mechanism alteration by HE4 up regulation. Here we reported that overexpressed HE4 promoted ovarian cancer cells proliferation, invasion and metastasis.
Liancheng, Zhu, Huiyu, Zhuang, Huimin, Wang, Mingzi, Tan, Carlton L, Schwab, Lu, Deng, Jian, Gao, Yingying, Hao, Xiao, Li, Song, Gao, Juanjuan, Liu, Bei, Lin   +11 more
openaire   +3 more sources

Kallikrein family proteases KLK6 and KLK7 are potential early detection and diagnostic biomarkers for serous and papillary serous ovarian cancer subtypes. [PDF]

, 2014
BACKGROUND: Early detection of ovarian cancer remains a challenge due to widespread metastases and a lack of biomarkers for early-stage disease. This study was conducted to identify relevant biomarkers for both laparoscopic and serum diagnostics in ...
Blake, Patrick, Chirina, Polina, Gharbaran, Rajendra, Goy, Andre, Hu, Wei, Jag, Ushma, Lim, Heejin, Oh Jeong, Jin, Patel, Hiren, Patwa, Ruzeen, Pecora, Andrew, Sarojini, Sreeja, Schindewolf, Craig, Sood, Anil, Suh, K Stephen, Tamir, Ayala, Tanaka, Takemi   +16 more
core   +2 more sources

WAP four-disulfide core domain protein 2 gene(WFDC2) is a target of estrogen in ovarian cancer cells [PDF]

, 2016
BACKGROUND: WAP four-disulfide core domain protein 2 (WFDC2) shows a tumor-restricted upregulated pattern of expression in ovarian cancer. METHODS: We investigated the role of estradiol (E2) on cell growth in estrogen-sensitive or estrogen-insensitive ...
A Bardin, A Hein, A Scott, A1CP Grimberg, AJM O’Donnell, BP Haynes, C Gourley, D Bouchard, D Zurawa-Janicka, E Anastasi, E Lokich, E Sonnet, EI Braicu, F Belin, H Suzuki, H Thomadaki, H1HM Chen, HC Pai, J Chien, J Frasor, J Zhu, Ji-Liang Li, K-A Hwang, L Lu, Ming Li, MTM Miyamoto, N Bansal, O Treeck, P-m Sun, PAM Obexer, Q Felty, RG Moore, RG Moore, RG Moore, SL Zou, SM Ho, Suihai Wang, T Fujiwara, TF Song, Tiancai Liu, V Manolov, W Hua, Y Chen, Yao Chen, YF Mahran, Yingsong Wu, Z-N Zhao   +46 more
core   +1 more source

Three-Dimensional Structure of Human Epididymis Protein 4 (HE4): A Protein Modelling of an Ovarian Cancer Biomarker Through In Silico Approach

Journal of Tropical Life Science
The Human Epididymis Protein 4 (HE4) biomarker has been extensively investigated for its potential in diagnosing ovarian cancer (OC). For the application of diagnostic techniques and drug delivery, it is crucial to understand the protein tertiary ...
Nur Nadiah Abdul Rashid, Mohd Hamzah Mohd Nasir, Nurasyikin Hamzah, Che Muhammad Khairul Hisyam Ismail, Siti Aishah Sufira Nor Hishamuddin, I. Suffian, Azzmer Azzar Abdul Hamid   +6 more
semanticscholar   +1 more source