Results 71 to 80 of about 4,477 (231)

Machine Learning‐Enhanced Analysis of Exosomal Surface Sialic Acid Using Surface‐Enhanced Raman Spectroscopy for Ovarian Cancer Diagnosis and Therapeutic Monitoring

Advanced Science, EarlyView.
Machine learning‐assisted surface‐enhanced Raman spectroscopy analysis of exosomal sialic acid for ovarian cancer diagnosis, as well as independent monitoring of exosomal sialic acid expression levels across different treatment periods, reveals a potential correlation with treatment response.
Lili Cong, Jiaqi Wang, Sijun Huang, Xiaxia Man, Yi Guo, Shuping Xu, Songling Zhang   +6 more
wiley   +1 more source

Knockdown of HE4 suppresses aggressive cell growth and malignant progression of ovarian cancer by inhibiting the JAK/STAT3 pathway

Biology Open, 2019
Human epididymis protein 4 (HE4) is well known to be a predictor of ovarian cancer clinically. HE4 is reported to play crucial roles in ovarian cancer progression and metastasis.
Aihong Wang, Canhui Jin, Xiaoyu Tian, Ying Wang, Hongyu Li   +4 more
doaj   +1 more source

Role of galectin-3 combined with multi-detector contrast enhanced computed tomography in predicting disease recurrence in patients with ovarian cancer [PDF]

, 2017
Galectin-3 (Gal-3) is an endogenous β-galactoside-binding lectin, playing an important role in the pathogenesis of multiple malignancies. Aim of the study was to evaluate in a group of patients treated for ovarian cancer (EOC), the role of Gal-3 ...
ANASTASI, Emanuela, ANGELONI, Antonio, BALLESIO, Laura, CATALANO, Carlo, GIGLI, SILVIA, Granato, T, MANGANARO, Lucia, PORPORA, Maria Grazia, SANTULLI, Maria, TARTAGLIONE, SARA   +9 more
core   +1 more source

HE4 in the evaluation of tumor load and prognostic stratification of high grade serous ovarian carcinoma [PDF]

, 2020
Objective Human epididymis protein 4 (HE4) is a validated, complementary biomarker to cancer antigen 125 (CA125) for high grade serous ovarian carcinoma (HGSC).
Carpen, Olli, Gidwani, Kamlesh, Grenman, Seija, Hietanen, Sakari, Huhtinen, Kaisa, Hynninen, Johanna, Pettersson, Kim, Salminen, Liina   +7 more
core   +1 more source

Evaluation of human epididymis protein 4 (HE4) and Risk of Ovarian Malignancy Algorithm (ROMA) as diagnostic tools of type I and type II epithelial ovarian cancer in Japanese women

Tumor Biology, 2014
Human epididymis protein 4 (HE4) levels and the Risk of Ovarian Malignancy Algorithm (ROMA) have recently been shown to improve the sensitivity and specificity of epithelial ovarian cancer (EOC) diagnosis.
H. Fujiwara, Mitsuaki Suzuki, N. Takeshima, K. Takizawa, E. Kimura, T. Nakanishi, Kyosuke Yamada, H. Takano, H. Sasaki, K. Koyama, K. Ochiai   +10 more
semanticscholar   +1 more source

Biomarker‐Agnostic Detection of Ovarian Cancer from Blood Plasma Using a Machine Learning‐Driven Electronic Nose

Advanced Intelligent Systems, EarlyView.
This study introduces a biomarker‐agnostic diagnostic strategy for ovarian cancer, utilizing a machine learning‐enhanced electronic nose to analyze volatile organic compound signatures from blood plasma. By overcoming the dependence on specific biomarkers, this approach enables accurate detection, staging, and cancer type differentiation, offering a ...
Ivan Shtepliuk, Lingyin Meng, Christer Borgfeldt, Jens Eriksson, Donatella Puglisi   +4 more
wiley   +1 more source

Association Between Micronutrient Concentrations and Human Epididymis Protein 4

Journal of Inflammation Research, 2021
Zhu Wei Lim,1 Wei Liang Chen2 1Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan; 2Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital and School of Medicine ...
Lim ZW, Chen WL
doaj  

Elevated serum levels of human epididymis protein 4 in adult patients with proliferative lupus nephritis

Frontiers in Immunology, 2023
BackgroundThis study aimed to access whether serum human epididymis protein 4 (HE4) level could identify lupus nephritis (LN) pathological classes in adults and children.MethodsThe serum HE4 levels of 190 healthy subjects and 182 patients with systemic ...
Liubing Li, Huiya Xu, Yuting Le, Runzhao Li, Qiong Shi, Hongji Zhu, Hongxu Xu, Laisheng Li, Min Liu, Fen Wang, Hui Zhang, Hui Zhang   +11 more
doaj   +1 more source

Exploring the impact of microbial dysbiosis on ovarian cancer and the therapeutic potential of probiotics

VIEW, EarlyView.
Ovarian cancer has been linked to the microbiome as a potential environmental contributor, but how this association relates to tumor progression remains unclear. By comparing tumor and nontumor tissues, we identified a severity‐associated microbial and metabolic signature and showed that probiotics can partially restore immune balance and slow tumor ...
Chanyuan Li, Nalan Tu, Xin Ning, Yunyan Cong, Fei Wu, Xiuli Zhang, Runrong Li, Yue Xu, Binqiao Wang, Liqin Jin, Yuanming Shen, Jihong Liu   +11 more
wiley   +1 more source

Interaction of HE4 and ANXA2 exists in various malignant cells—HE4–ANXA2–MMP2 protein complex promotes cell migration

Cancer Cell International, 2019
Background The interaction between human epididymis protein 4 (HE4) and annexin A2 (Annexin A2) has been found in ovarian cancer. However, it is dimness whether the interaction exists in other malignant tumors. Methods Real-time PCR, western blotting and
Jing Wang, Lu Deng, Huiyu Zhuang, Juanjuan Liu, Dawo Liu, Xiao Li, Shan Jin, Liancheng Zhu, Huimin Wang, Bei Lin   +9 more
doaj   +1 more source