Results 11 to 20 of about 382,259 (299)
Prader-Willi syndrome and growth hormone therapy: exploring the precise management of hypothalamic short stature: A review [PDF]
Precision and Future Medicine, 2023 Prader-Willi syndrome (PWS) is a rare genetic disorder characterized by various clinical features linked to hypothalamic/pituitary gland abnormalities. Growth hormone deficiency is a prominent feature of PWS that results in poor linear growth and delayed
Aram Yang
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Effects of human growth hormone on gonadotropin-releasing hormone neurons in mice [PDF]
Korean Journal of Pediatrics, 2010 PurposeRecombinant human growth hormone (rhGH) has been widely used to treat short stature. However, there are some concerns that growth hormone treatment may induce skeletal maturation and early onset of puberty.
Janardhan P. Bhattarai +3 more
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Orphanet Journal of Rare Diseases, 2023 Background Somatropin treatment is indicated in a variety of disorders including growth hormone (GH) deficiency, Prader–Willi and Turner syndrome, chronic renal insufficiency and others. To date, almost all studies have been limited to single GH products,
Dirk Schnabel +6 more
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Effectiveness of Recombinant Human Growth Hormone for Pharyngocutaneous Fistula Closure [PDF]
Clinical and Experimental Otorhinolaryngology, 2015 ObjectivesIn laryngeal cancer, which comprises 25% of head and neck cancer, chemotherapy has come into prominence with the increase in organ-protective treatments.
Nurten Kucuk +5 more
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Enhancement of The Stability of Human Growth Hormone by Using Tris(hydroxymethyl)aminomethane: Molecular Docking and Experimental Analysis [PDF]
Cell Journal, 2021 Objective: It is so difficult to formulate human growth hormone (hGH) in a solution with high stability and new drug delivery system (NDDs) due to physiochemical instability. The purpose of this study was to investigate the possibility of using Tris as
Siyavash Mirzaei +6 more
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Diabetes, 1959 THE recent isolation of human growth hormone from pituitary glands collected at autopsy has been of major importance in the investigation of human pituitary physiology.1 , 2 Metabolic studies have confirmed the remarkable anabolic and growth-promoting actions of this hormone in man,3 , 4 in contrast to the negative or equivocal clinical results ...
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Perspectives on long-acting growth hormone therapy in children and adults
Archives of Endocrinology and Metabolism, 2020 Growth hormone therapy with daily injections of recombinant human growth hormone has been available since 1985, and is shown to be safe and effective treatment for short stature in children and for adult growth hormone deficiency. In an effort to produce
Rayhan A. Lal, Andrew R. Hoffman
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Italian Journal of Pediatrics, 2019 Background The treatment with recombinant human growth hormone in patients affected by Mucopolysaccharidoses (MPS) is considered whenever a concurrent diagnosis of growth hormone deficiency is demonstrated. The short- and long-term effects of recombinant
A. Cattoni +5 more
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Short Stature in children: Review Article
SVU - International Journal of Medical Sciences, 2023 Background: Humans' final adult height is influenced by a variety of factors. A common paediatric endocrine issue, short stature has a variety of reasons, but normal variations account for the majority of cases.
Ahmed El-Abd Ahmed +3 more
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Frontiers in Endocrinology, 2022 Jintrolong® is a long-acting PEGylated recombinant human growth hormone (PEG-rhGH) developed for weekly injection in patients with pediatric growth hormone deficiency (PGHD). Although PEG modification of therapeutic proteins is generally considered safe,
Wei Wu +15 more
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