Results 51 to 60 of about 122,903 (146)

HHV-6A/B Integration and the Pathogenesis Associated with the Reactivation of Chromosomally Integrated HHV-6A/B

Viruses, 2017
Unlike other human herpesviruses, human herpesvirus 6A and 6B (HHV-6A/B) infection can lead to integration of the viral genome in human chromosomes. When integration occurs in germinal cells, the integrated HHV-6A/B genome can be transmitted to 50% of ...
Vanessa Collin, Louis Flamand
doaj   +1 more source

Human Herpesvirus 6A Infection and Immunopathogenesis in Humanized Rag2^−/−γc^−/−Mice [PDF]

Journal of Virology, 2013
ABSTRACTAlthough serious human diseases have been correlated with human herpesvirus 6A (HHV-6A) and HHV-6B, the lack of animal models has prevented studies which would more definitively link these viral infections to disease. HHV-6A and HHV-6B have recently been classified as two distinct viruses, and in this study we focused specifically on developing
Anne, Tanner, Stephanie A, Carlson, Masatoshi, Nukui, Eain A, Murphy, Bradford K, Berges   +4 more
openaire   +2 more sources

Novel marmoset (Callithrix jacchus) model of human Herpesvirus 6A and 6B infections: immunologic, virologic and radiologic characterization. [PDF]

PLoS Pathogens, 2013
Human Herpesvirus 6 (HHV-6) is a ubiquitous virus with an estimated seroprevalence of 95% in the adult population. HHV-6 is associated with several neurologic disorders, including multiple sclerosis, an inflammatory demyelinating disease affecting the ...
Emily Leibovitch, Jillian E Wohler, Sheila M Cummings Macri, Kelsey Motanic, Erin Harberts, María I Gaitán, Pietro Maggi, Mary Ellis, Susan Westmoreland, Afonso Silva, Daniel S Reich, Steven Jacobson   +11 more
doaj   +1 more source

Enhanced virus reconstitution of human herpesvirus 6A (HHV-6A)

BMC Methods
Abstract Background Human herpesvirus 6A (HHV-6A) is a member of the betaherpesvirus family and is associated with neurotropic diseases. Despite its clinical significance, HHV-6A research has been hampered by challenges in the generation of recombinant viruses.
Reich, Jana, Serdar, Dilan, Ospina, Jenny M., Cheng, Yingnan, Weißmann, Ann-Christin, Woude, Roosmarijn van der, Beythien, Georg, Whyte, Melissa L., Gravel, Annie, Hennig, Thomas, Flamand, Louis, Hudson, Amy, Kaufer, Benedikt B.   +12 more
openaire   +2 more sources

Comparative characteristics of human betaherpesviruses 6A and 6B. A modern view on the problem

Журнал инфектологии, 2021
This review is devoted to the comparative characteristics of human herpesvirus 6A (HHV6A) and human herpesvirus 6B (HHV6B), taking into account their exogenous and endogenous (inherited chromosomally integrated) forms. The analysis of the literature data
M. I. Popkova, O. V. Utkin, D. A. Bryzgalova   +2 more
doaj   +1 more source

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

Human Herpesviruses-encoded dUTPases: A Family of Proteins that Modulate Dendritic Cell Function and Innate Immunity

Frontiers in Microbiology, 2014
We have previously shown that Epstein-Barr virus (EBV)-encoded dUTPase can modulate innate immune responses through the activation of TLR2 and NF-kappaB signaling. However, whether this novel immune function of the dUTPase is specific for EBV or a common
Maria Eugenia eAriza, Ronald eGlaser, Marshall Vance Williams   +2 more
doaj   +1 more source

Anti-human herpesvirus 6A/B IgG correlates with relapses and progression in multiple sclerosis. [PDF]

PLoS ONE, 2014
To analyze the titers of the IgG and IgM antibodies against human herpesvirus 6A/B (HHV-6A/B) in multiple sclerosis (MS) patients treated with different disease modified therapies (DMTs) along two-years of follow-up.We collected 2163 serum samples from ...
Isabel Ortega-Madueño, Marta Garcia-Montojo, Maria Inmaculada Dominguez-Mozo, Angel Garcia-Martinez, Ana Maria Arias-Leal, Ignacio Casanova, Rafael Arroyo, Roberto Alvarez-Lafuente   +7 more
doaj   +1 more source

Clinical and etiological aspects of human Betaherpesvirus infection 6: a review

Журнал инфектологии, 2022
The literature review is devoted to the modern concept of human betaherpesvirus 6 (human herpesvirus 6; HHV-6). The analysis of the literature mainly for the last five years was carried out.
N. S. Tian, O. V. Goleva, I. V. Babachenko   +2 more
doaj   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source