Results 151 to 160 of about 5,646 (167)

Computer modeling of human islet amyloid polypeptide

2016
It is believed that a variety of human diseases are related to the misfolding of proteins or peptides. Amyloid fibrils are highly organized aggregates with a cross-? structure and are generated by misfolding of proteins. These aggregates are also related to disease. For instance, human islet amyloid polypeptide (hIAPP), ?-synuclein, and amyloid-?
openaire   +1 more source

Cross-Seeding Interaction between β-Amyloid and Human Islet Amyloid Polypeptide

ACS Chemical Neuroscience, 2015
Alzheimer's disease (AD) and type 2 diabetes (T2D) are two common protein misfolding diseases. Increasing evidence suggests that these two diseases may be correlated with each other via cross-sequence interactions between β-amyloid peptide (Aβ) associated with AD and human islet amyloid polypeptide (hIAPP) associated with T2D.
Rundong, Hu, Mingzhen, Zhang, Hong, Chen, Binbo, Jiang, Jie, Zheng   +4 more
openaire   +2 more sources

2D amyloid aggregation of human islet amyloid polypeptide at the solid–liquid interface

Soft Matter, 2012
Protein misfolding, aggregation, and amyloid deposits are the common hallmarks of amyloid diseases, such as Alzheimer's disease, type 2 diabetes mellitus (T2DM), Huntington disease, prion disease, and Parkinson's disease. In the case of T2DM, the aggregation of human islet amyloid polypeptide (hIAPP) accumulates in the pancreatic islets, which has the ...
Yu, Y.-P., Zhang, S., Liu, Q., Li, Y.-M., Wang, C., Besenbacher, F., Dong, M.; id_orcid 0000-0002-2025-2171   +6 more
openaire   +2 more sources

Islet-amyloid polypeptide in human plasma

The Lancet, 1990
Van Jaarsveld, B. C., Hackeng, W. H.L., Nieuwenhuis, M. G., Erkelens, D. W., Geerdink, R. A., Lips, C. J.M.   +5 more
openaire   +2 more sources

Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets

Diabetologia, 1989
Per Westermark, Gunilla Westermark, E Wilander   +2 more
exaly  

Chronic overproduction of islet amyloid polypeptide/amylin in transgenic mice: lysosomal localization of human islet amyloid polypeptide and lack of marked hyperglycaemia or hyperinsulinaemia

Diabetologia, 1993
Eelco de Koning, H S Jansz, J F Morris
exaly  

Inhibitory Mechanism of Epigallocatechin Gallate on Fibrillation and Aggregation of Amidated Human Islet Amyloid Polypeptide

ChemPhysChem, 2017
Zhou Ping, Yang Hongjie
exaly  

Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors

Journal of Biological Chemistry, 2018
Ji Lee, Duilio Cascio
exaly  

Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets

Diabetologia, 2006
Johan F Paulsson, Per Westermark, Andersson A   +2 more
exaly  

Design of Peptide-based Inhibitors of Human Islet Amyloid Polypeptide Fibrillogenesis

Journal of Molecular Biology, 2002
Joanne Mclaurin
exaly