Results 51 to 60 of about 119,573 (312)

Reduced TRPC channel expression in psoriatic keratinocytes is associated with impaired differentiation and enhanced proliferation

, 2011
Psoriasis is a characteristic inflammatory and scaly skin condition with typical histopathological features including increased proliferation and hampered differentiation of keratinocytes.
Ute Woelfle, Kristina Leuner, Schempp, Christoph M., Kraus, Margarethe, Walter E Müller, Harteneck Christian, Christoph M. Schempp, Walter E. Müller, Margarethe Kraus, Harteneck, Christian, Beschmann, Heike, Beschmann, Heike A., Boehncke, Wolf-Henning, Beschmann Heike, Boehncke Wolf-Henning, Schempp Christoph M., Kraus Margarethe, Christoph M Schempp, Schempp, Christoph Mathis, Wolf-Henning Boehncke, Heike Beschmann, Christian Harteneck, Woelfle Ute, Leuner Kristina, Leuner, Kristina, Wölfle, Ute, Müller Walter E., Woelfle, Ute, Müller, Walter E.   +28 more
core   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Locomotion of Human Skin Keratinocytes on Polystyrene, Fibrin, and Collagen Substrata and its Modification by Cell-to-Cell Contacts

Cell Transplantation, 2001
Epithelial wound repair assures the recovery of the epithelial barrier after wounding. During wound healing epithelial cells migrate to cover the wound surface.
Justyna Drukala Ph.D., Laura Bandura, Kazimierz Cieślik, Włodzimierz Korohoda   +3 more
doaj   +1 more source

C10orf99/GPR15L Regulates Proinflammatory Response of Keratinocytes and Barrier Formation of the Skin

Frontiers in Immunology, 2022
The epidermis, outermost layer of the skin, forms a barrier and is involved in innate and adaptive immunity in an organism. Keratinocytes participate in all these three protective processes.
Teruki Dainichi, Teruki Dainichi, Yuri Nakano, Hiromi Doi, Satoshi Nakamizo, Satoshi Nakamizo, Saeko Nakajima, Saeko Nakajima, Reiko Matsumoto, Thomas Farkas, Pui Mun Wong, Vipin Narang, Ricardo Moreno Traspas, Eiryo Kawakami, Eiryo Kawakami, Emma Guttman-Yassky, Oliver Dreesen, Thomas Litman, Bruno Reversade, Kenji Kabashima, Kenji Kabashima   +20 more
doaj   +1 more source

Asymmetric Migration of Human Keratinocytes under Mechanical Stretch and Cocultured Fibroblasts in a Wound Repair Model [PDF]

, 2013
Keratinocyte migration during re-epithelization is crucial in wound healing under biochemical and biomechanical microenvironment. However, little is known about the underlying mechanisms whereby mechanical tension and cocultured fibroblasts or ...
Gao YX(高宇欣), Luo XD, Long M(龙勉), Liu XF(刘晓锋), Sun SJ(孙树津), Kang YY(康英永), Long, MA (reprint author), Chinese Acad Sci, Inst Mech, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100080, Peoples R China, Chen L, Chen J(陈娟), Lü DY(吕东媛), Huo B(霍波)   +10 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Glycofullerenes Inhibit Particulate Matter Induced Inflammation and Loss of Barrier Proteins in HaCaT Human Keratinocytes

Biomolecules, 2020
Exposure to particulate matter (PM) has been linked to pulmonary and cardiovascular dysfunctions, as well as skin diseases, etc. PM impairs the skin barrier functions and is also involved in the initiation or exacerbation of skin inflammation, which is ...
Chiang-Wen Lee, Yu-Han Su, Yao-Chang Chiang, I-Ta Lee, Sin-Yu Li, Hui-Chun Lee, Lee-Fen Hsu, Yi-Ling Yan, Hsing-Yen Li, Ming-Chun Chen, Kuo-Ti Peng, Chian-Hui Lai   +11 more
doaj   +1 more source

Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt

, 2004
The forkhead transcription factor FOXN1 is required for normal cutaneous and thymic epithelial development. Mutations in FOXN1 give rise to the nude phenotype in mice, rats and man. However, the genes that are regulated by FOXN1 are unknown.
Ofstad, T.A., David M. Prowse, Douglas H. Campbell, Janes, Sam M., Janes, S.M., Prowse, D.M., Prowse, David M., Ofstad, Tyler A., Sam M. Janes, Fiona M. Watt, Watt, F.M., Tyler A. Ofstad, Watt, Fiona M., Campbell, Douglas H., Campbell, D.H.   +14 more
core   +1 more source

Tissue‐Stimulator Platform for Electrically Stimulating Pancreatic β‐Cells for Long‐Term Functional Regulation

Advanced Functional Materials, EarlyView.
We present a tissue‐stimulator platform for seamless electrode integration with pancreatic tissue, applying uniform electrical stimulation through optimized design with biohybrid 3D printing. Advantageous effects of electrical stimulation on β‐cell function were observed, including enhanced calcium signaling, islet morphology, and maturation.
Jihwan Kim, Uijung Yong, Myungji Kim, Jaewook Kim, Yeonggwon Jo, In Kyong Shim, Song Cheol Kim, Jinah Jang   +7 more
wiley   +1 more source

Oligonucleotides suppress PKB/Akt and act as superinductors of apoptosis in human keratinocytes

, 2009
DNA oligonucleotides (ODN) applied to an organism are known to modulate the innate and adaptive immune system. Previous studies showed that a CpG-containing ODN (CpG-1-PTO) and interestingly, also a non-CpG-containing ODN (nCpG- 5-PTO) suppress ...
Annette Dorn, Diamant Thaçi, Hofmann, Matthias, Roland Kaufmann, Andreas Bock, Maike Schultz, Thaçi, Diamant, Stefan Kippenberger, Bock, Andreas, Schultz, Maike, Dorn, Annette, Hüseyin Aygün, Kippenberger, Stefan, August Bernd, Matthias Hofmann, Aygün, Hüseyin, Bernd, August, Müller, Jutta, Kaufmann, Roland, Jutta Müller   +19 more
core   +1 more source