Results 51 to 60 of about 7,596,165 (249)
Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection
FEBS Open Bio, EarlyView.Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow +12 more
wiley +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Keratinocytes from human skin respond as typical immune cells after the stimulation with _Trichophyton rubrum_ [PDF]
, 2007 _Trichophyton rubrum_ is the main agent causing dermatophytosis (1). Keratinocytes are considered to be the first physical barrier of defense against pathogens (2). But not only a physical barrier.
Luz A. García-Madrid +1 more
core
Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes [PDF]
, 2010 Background The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation during cell division.
Chaplin Tracy +14 more
core +1 more source
A mechanistic investigation into candidate markers of telomere-induced senescence in normal human epidermal keratinocytes [PDF]
, 2014 PhDTelomere dysfunction is one mechanism of cellular and tissue ageing. Dysfunctional telomeres in fibroblasts are recognised as DNA double-strand breaks (DSBs) and trigger the DNA damage pathway of senescence.
dos Santos Soares Martins de Castro, Alicia Maria
core +4 more sources
Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration
Advanced Healthcare Materials, EarlyView.This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu +4 more
wiley +1 more source
Vitamin D analogs differentially control antimicrobial peptide/"alarmin" expression in psoriasis [PDF]
, 2009 Antimicrobial peptides (AMPs) are strongly expressed in lesional skin in psoriasis and play an important role as proinflammatory "alarmins" in this chronic skin disease.
Koglin, Sarah +30 more
core +2 more sources
Molecules, 2022 Kalanchoe species are succulents with anti-inflammatory, antioxidant, and analgesic properties, as well as cytotoxic activity. One of the most popular species cultivated in Europe is Kalanchoe daigremontiana Raym.-Hamet and H. Perrier.
Justyna Stefanowicz-Hajduk +6 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park +5 more
wiley +1 more source
Medicina, 2023 Three ceramic and composite computer-aided design/computer-aided manufacturing (CAD/CAM) materials from different manufacturers (Cerasmart (CS)—nanoceramic resin; Straumann Nice (SN)—glass ceramic and Tetric CAD (TC)—composite resin) were tested to ...
Codruța Eliza Ille +5 more
doaj +1 more source