Results 31 to 40 of about 7,596,165 (249)

Nickel Nanoparticles Induce the Synthesis of a Tumor-Related Polypeptide in Human Epidermal Keratinocytes

Nanomaterials, 2020
Although nickel allergy and carcinogenicity are well known, their molecular mechanisms are still uncertain, thus demanding studies at the molecular level.
Javier Jiménez-Lamana, Simon Godin, Gerard Aragonès, Cinta Bladé, Joanna Szpunar, Ryszard Łobinski   +5 more
doaj   +1 more source

Functional characterization of cultured keratinocytes after acute cutaneous burn injury. [PDF]

, 2012
In addition to forming the epithelial barrier against the outside environment keratinocytes are immunologically active cells. In the treatment of severely burned skin, cryoconserved keratinocyte allografts gain in importance.
Gerd G Gauglitz, Faist Eugen, Guido Henkel von Donnersmarck, Eugen Faist, v. Spiegel Felix, Spiegel, Felix von, Faist, Eugen, Zedler Siegfried, Siegfried Zedler, Felix von Spiegel, v. Donnersmarck Guido Henkel, Fuhr, Jasmin, Jasmin Fuhr, Gauglitz, Gerd, Henkel von Donnersmarck, Guido, Fuhr Jasmin, Zedler, Siegfried, Gauglitz Gerd G.   +17 more
core   +2 more sources

Protective Effect of Pomegranate on Oxidative Stress and Inflammatory Response Induced by 5-Fluorouracil in Human Keratinocytes

Antioxidants, 2021
5-Fluorouracil (5-FU) is a pyrimidine analogue used as an antineoplastic agent to treat multiple solid tumors. Despite its use and efficacy, it also has important side effects in healthy cells, including skin reactions, related to its pro-oxidant and pro-
Shara Francesca Rapa, Giorgia Magliocca, Giacomo Pepe, Giuseppina Amodio, Giuseppina Autore, Pietro Campiglia, Stefania Marzocco   +6 more
doaj   +1 more source

Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt [PDF]

, 2004
The forkhead transcription factor FOXN1 is required for normal cutaneous and thymic epithelial development. Mutations in FOXN1 give rise to the nude phenotype in mice, rats and man. However, the genes that are regulated by FOXN1 are unknown.
Ofstad, T.A., David M. Prowse, Douglas H. Campbell, Janes, Sam M., Janes, S.M., Prowse, D.M., Prowse, David M., Ofstad, Tyler A., Sam M. Janes, Fiona M. Watt, Watt, F.M., Tyler A. Ofstad, Watt, Fiona M., Campbell, Douglas H., Campbell, D.H.   +14 more
core   +1 more source

Topical colchicine selection of keratinocytes transduced with the multidrug resistance gene (MDR1) can sustain and enhance transgene expression in vivo [PDF]

, 2004
In gene therapy, a clinically relevant therapeutic effect requires long-term expression of the desired gene at a level sufficient to correct or at least alleviate the underlying gene defect.
Pfützner, Wolfgang, Vogel, Jonathan C.
core   +2 more sources

Comparative Evaluation of Different Chitosan Species and Derivatives as Candidate Biomaterials for Oxygen-Loaded Nanodroplet Formulations to Treat Chronic Wounds

Marine Drugs, 2021
Persistent hypoxia is a main clinical feature of chronic wounds. Intriguingly, oxygen-loaded nanodroplets (OLNDs), filled with oxygen-solving 2H,3H-decafluoropentane and shelled with polysaccharides, have been proposed as a promising tool to counteract ...
Monica Argenziano, Bruno Bressan, Anna Luganini, Nicole Finesso, Tullio Genova, Adriano Troia, Giuliana Giribaldi, Giuliana Banche, Narcisa Mandras, Anna Maria Cuffini, Roberta Cavalli, Mauro Prato   +11 more
doaj   +1 more source

Oligonucleotides suppress PKB/Akt and act as superinductors of apoptosis in human keratinocytes [PDF]

, 2009
DNA oligonucleotides (ODN) applied to an organism are known to modulate the innate and adaptive immune system. Previous studies showed that a CpG-containing ODN (CpG-1-PTO) and interestingly, also a non-CpG-containing ODN (nCpG- 5-PTO) suppress ...
Annette Dorn, Diamant Thaçi, Hofmann, Matthias, Roland Kaufmann, Andreas Bock, Maike Schultz, Thaçi, Diamant, Stefan Kippenberger, Bock, Andreas, Schultz, Maike, Dorn, Annette, Hüseyin Aygün, Kippenberger, Stefan, August Bernd, Matthias Hofmann, Aygün, Hüseyin, Bernd, August, Müller, Jutta, Kaufmann, Roland, Jutta Müller   +19 more
core   +1 more source

EpCAM Induction Functionally Links to the Wnt-Enhanced Cell Proliferation in Human Keratinocytes

Cell Transplantation, 2014
Accelerating proliferation of primary keratinocytes benefits skin autografts for severely burned patients. Wnt signal, a conserved pathway controlling cell cycle and morphogenesis in embryo, also involves in cell proliferation and tumorigenesis in adult ...
Ching-I Shen, Hsiu-Chin Lee, Ying-Hsien Kao, Chieh-Shan Wu, Po-Hung Chen, Shinn-Zong Lin, Ping-Shan Lai, Hong-Lin Su   +7 more
doaj   +1 more source

Protective Effects of Violaxanthin on Cellular Oxidative Stress via NRF2 Activation in H₂O₂-Stimulated Human Keratinocytes

Applied Sciences
Excessive accumulation of reactive oxygen species from exogenous and endogenous stressors can cause cellular damage. Chlorella contains diverse bioactive compounds, and violaxanthin, a major carotenoid pigment found in Chlorella sp.
Ji-Seon Kim, Hee Su Kim, Hee-Jae Shin, Seokmuk Park, Ji Won Kim, Su-Bin Park, Hee-Sik Kim, Yong Jae Lee, Seunghee Bae   +8 more
doaj   +1 more source

Human Basal and Suprabasal Keratinocytes Are Both Able to Generate and Maintain Dermo–Epidermal Skin Substitutes in Long-Term In Vivo Experiments

Cells, 2022
The basal layer of human interfollicular epidermis has been described to harbour both quiescent keratinocyte stem cells and a transit amplifying cell population that maintains the suprabasal epidermal layers.
Luca Pontiggia, Akshay Kumar Ahuja, Hesham Kamaleldin Yosef, Dominic Rütsche, Ernst Reichmann, Ueli Moehrlen, Thomas Biedermann   +6 more
doaj   +1 more source