Results 21 to 30 of about 102,593 (165)

Gibberellic Acid Initiates ER Stress and Activation of Differentiation in Cultured Human Immortalized Keratinocytes HaCaT and Epidermoid Carcinoma Cells A431

Pharmaceutics, 2021
Diterpenoid plant hormone gibberellic acid (GA) plays an important role in regulation of plant growth and development and is commonly used in agriculture for activation of plant growth and food production.
Mariya Vildanova, Polina Vishnyakova, Aleena Saidova, Victoria Konduktorova, Galina Onishchenko, Elena Smirnova   +5 more
doaj   +1 more source

The anti-inflammatory and analgesic potential of the probiotic Streptococcus thermophilus via inhibition of endocannabinoid-degrading enzymes: a preliminary in vitro study [PDF]

Exploration of Immunology
Aim: The benefit of topical application of probiotics on pain and itching associated with skin disorders has become an increasingly intriguing topic in recent years.
Serena Altamura, Elona Dybeli, Francesca Lombardi, Paola Palumbo, Francesca Rosaria Augello, Skender Topi, Maria Grazia Cifone, Benedetta Cinque   +7 more
doaj   +1 more source

OR2AT4, an Ectopic Olfactory Receptor, Suppresses Oxidative Stress-Induced Senescence in Human Keratinocytes

Antioxidants, 2022
Olfactory receptors (ORs) are the largest protein superfamily in mammals. Certain ORs are ectopically expressed in extranasal tissues and regulate cell type-specific signal transduction pathways. OR2AT4 is ectopically expressed in skin cells and promotes
Ji-Sun Kim, Ha Lim Lee, Ji Hyun Jeong, Ye Eun Yoon, In-Ryeong Lee, Ji Min Kim, Chunyan Wu, Sung-Joon Lee   +7 more
doaj   +1 more source

Pyruvate Kinase M2 Accelerates Cutaneous Wound Healing via Glycolysis and Wnt/β-Catenin Signaling

Pharmaceutics, 2023
Cutaneous wound healing is a complex and dynamic process with high energy demand. The activation of glycolysis is essential for restoring the structure and function of injured tissues in wounds. Pyruvate kinase M2 (PKM2) is an enzyme that plays a crucial
Eunhwan Kim, Yumi Hwang, Heejene Kim, Geon-Uk Kim, Yeong Chan Ryu, Minguen Yoon, Kang-Yell Choi   +6 more
doaj   +1 more source

Mupirocin Promotes Wound Healing by Stimulating Growth Factor Production and Proliferation of Human Keratinocytes

Frontiers in Pharmacology, 2022
Mupirocin has been reported for its role in the treatment of infected wounds through its antibacterial activity, however the role of mupirocin in promoting wound healing via alternative mechanisms has not been extensively evaluated.
Danielle Twilley, Oleg Reva, Debra Meyer, Namrita Lall, Namrita Lall, Namrita Lall, Namrita Lall   +6 more
doaj   +1 more source

Methicillin-Resistant Staphylococcus aureus Adaptation to Human Keratinocytes

mBio, 2015
Skin is the most common site of Staphylococcus aureus infection. While most of these infections are self-limited, recurrent infections are common. Keratinocytes and recruited immune cells participate in skin defense against infection.
Grace Soong, Franklin Paulino, Sarah Wachtel, Dane Parker, Matthew Wickersham, Dongni Zhang, Armand Brown, Christine Lauren, Margaret Dowd, Emily West, Basil Horst, Paul Planet, Alice Prince   +12 more
doaj   +1 more source

Measles skin rash: Infection of lymphoid and myeloid cells in the dermis precedes viral dissemination to the epidermis.

PLoS Pathogens, 2020
Measles is characterized by fever and a maculopapular skin rash, which is accompanied by immune clearance of measles virus (MV)-infected cells. Histopathological analyses of skin biopsies from humans and non-human primates (NHPs) with measles rash have ...
Brigitta M Laksono, Paola Fortugno, Bernadien M Nijmeijer, Rory D de Vries, Sonia Cordisco, Thijs Kuiken, Teunis B H Geijtenbeek, W Paul Duprex, Francesco Brancati, Rik L de Swart   +9 more
doaj   +1 more source

Oncostatin M Induction of Monocyte Chemoattractant Protein 1 is Inhibited by Anti-oncostatin M Receptor Beta Monoclonal Antibody KPL-716

Acta Dermato-Venereologica, 2020
To evaluate cellular response to oncostatin M (OSM) in comparison to interleukin (IL)-31, we analyzed monocyte chemoattractant protein 1 (MCP-1) as a readout for OSM responses with and without IL-4, IL-13, anti-OSM receptor β monoclonal antibody KPL-716,
Carl D. Richards, Rohan Gandhi, Fernando Botelho, Lilian Ho, John F. Paolini   +4 more
doaj   +1 more source

Human Keratinocytes Catabolize Thymidine

Journal of Investigative Dermatology, 1988
Human neonatal foreskin keratinocytes incorporate exogenous thymidine into DNA and proliferate in vitro even after reaching confluence. Keratinocytes also catabolize thymidine, as reported for the first time below. Stratified cultures of keratinocytes reduced the amount of thymidine in the medium by more than 90% within 2 to 4 h. Consequently, the rate
Schwartz, Pauline M., Kugelman, Lisa C., Coifman, Yael., Hough, Lynne M., Milstone, Leonard M.   +4 more
openaire   +2 more sources

Insulin‐like growth factor‐1 receptor regulates repair of ultraviolet B‐induced DNA damage in human keratinocytes in vivo

Molecular Oncology, 2016
The activation status of the insulin‐like growth factor‐1 receptor (IGF‐1R) regulates the cellular response of keratinocytes to ultraviolet B (UVB) exposure, both in vitro and in vivo.
Mathew M. Loesch, Ann E. Collier, David H. Southern, Rachel E. Ward, Sunil S. Tholpady, Davina A. Lewis, Jeffrey B. Travers, Dan F. Spandau   +7 more
doaj   +1 more source