Results 21 to 30 of about 7,596,165 (249)

Pyruvate Kinase M2 Accelerates Cutaneous Wound Healing via Glycolysis and Wnt/β-Catenin Signaling

Pharmaceutics, 2023
Cutaneous wound healing is a complex and dynamic process with high energy demand. The activation of glycolysis is essential for restoring the structure and function of injured tissues in wounds. Pyruvate kinase M2 (PKM2) is an enzyme that plays a crucial
Eunhwan Kim, Yumi Hwang, Heejene Kim, Geon-Uk Kim, Yeong Chan Ryu, Minguen Yoon, Kang-Yell Choi   +6 more
doaj   +1 more source

Mupirocin Promotes Wound Healing by Stimulating Growth Factor Production and Proliferation of Human Keratinocytes

Frontiers in Pharmacology, 2022
Mupirocin has been reported for its role in the treatment of infected wounds through its antibacterial activity, however the role of mupirocin in promoting wound healing via alternative mechanisms has not been extensively evaluated.
Danielle Twilley, Oleg Reva, Debra Meyer, Namrita Lall, Namrita Lall, Namrita Lall, Namrita Lall   +6 more
doaj   +1 more source

Entry pathways of herpes simplex virus type 1 into human keratinocytes are dynamin- and cholesterol-dependent [PDF]

, 2011
Herpes simplex virus type 1 (HSV-1) can enter cells via endocytic pathways or direct fusion at the plasma membrane depending on the cell line and receptor(s).
Mei-Ju Hsu, Frazer J. Rixon, Petermann, P., Rixon Frazer J., Rahn, E., Hsu Mei-Ju, Knebel-Mörsdorf, D., Geraghty, R.J., Dagmar Knebel-Mörsdorf, Rahn Elena, Philipp Petermann, Knebel-Mörsdorf Dagmar, Elena Rahn, Frazer J Rixon, Hsu, M.-J., Rixon, F.J., Petermann Philipp   +16 more
core   +1 more source

Methicillin-Resistant Staphylococcus aureus Adaptation to Human Keratinocytes

mBio, 2015
Skin is the most common site of Staphylococcus aureus infection. While most of these infections are self-limited, recurrent infections are common. Keratinocytes and recruited immune cells participate in skin defense against infection.
Grace Soong, Franklin Paulino, Sarah Wachtel, Dane Parker, Matthew Wickersham, Dongni Zhang, Armand Brown, Christine Lauren, Margaret Dowd, Emily West, Basil Horst, Paul Planet, Alice Prince   +12 more
doaj   +1 more source

Measles skin rash: Infection of lymphoid and myeloid cells in the dermis precedes viral dissemination to the epidermis.

PLoS Pathogens, 2020
Measles is characterized by fever and a maculopapular skin rash, which is accompanied by immune clearance of measles virus (MV)-infected cells. Histopathological analyses of skin biopsies from humans and non-human primates (NHPs) with measles rash have ...
Brigitta M Laksono, Paola Fortugno, Bernadien M Nijmeijer, Rory D de Vries, Sonia Cordisco, Thijs Kuiken, Teunis B H Geijtenbeek, W Paul Duprex, Francesco Brancati, Rik L de Swart   +9 more
doaj   +1 more source

Oncostatin M Induction of Monocyte Chemoattractant Protein 1 is Inhibited by Anti-oncostatin M Receptor Beta Monoclonal Antibody KPL-716

Acta Dermato-Venereologica, 2020
To evaluate cellular response to oncostatin M (OSM) in comparison to interleukin (IL)-31, we analyzed monocyte chemoattractant protein 1 (MCP-1) as a readout for OSM responses with and without IL-4, IL-13, anti-OSM receptor β monoclonal antibody KPL-716,
Carl D. Richards, Rohan Gandhi, Fernando Botelho, Lilian Ho, John F. Paolini   +4 more
doaj   +1 more source

Graphene Nanoplatelets: In Vivo and In Vitro Toxicity, Cell Proliferative Activity, and Cell Gene Expression

Applied Sciences, 2022
Multi-layer graphene (2–10 layers), also called graphene nanoplatelets (GNPs), is a carbon-based nanomaterial (CBN) type with excellent properties desirable for many biomedical applications.
Beatriz Salesa, Alberto Tuñón-Molina, Alba Cano-Vicent, Marcelo Assis, Juan Andrés, Ángel Serrano-Aroca   +5 more
doaj   +1 more source

Insulin‐like growth factor‐1 receptor regulates repair of ultraviolet B‐induced DNA damage in human keratinocytes in vivo

Molecular Oncology, 2016
The activation status of the insulin‐like growth factor‐1 receptor (IGF‐1R) regulates the cellular response of keratinocytes to ultraviolet B (UVB) exposure, both in vitro and in vivo.
Mathew M. Loesch, Ann E. Collier, David H. Southern, Rachel E. Ward, Sunil S. Tholpady, Davina A. Lewis, Jeffrey B. Travers, Dan F. Spandau   +7 more
doaj   +1 more source

Human keratinocytes are vanilloid resistant. [PDF]

PLoS ONE, 2008
BACKGROUND: Use of capsaicin or resiniferatoxin (RTX) as analgesics is an attractive therapeutic option. RTX opens the cation channel inflammatory pain/vanilloid receptor type 1 (TRPV1) permanently and selectively removes nociceptive neurons by Ca(2 ...
László Pecze, Kornélia Szabó, Márta Széll, Katalin Jósvay, Krisztián Kaszás, Erzsébet Kúsz, Tamás Letoha, János Prorok, István Koncz, András Tóth, Lajos Kemény, Csaba Vizler, Zoltán Oláh   +12 more
doaj   +1 more source

Reduced TRPC channel expression in psoriatic keratinocytes is associated with impaired differentiation and enhanced proliferation [PDF]

, 2011
Psoriasis is a characteristic inflammatory and scaly skin condition with typical histopathological features including increased proliferation and hampered differentiation of keratinocytes.
Ute Woelfle, Kristina Leuner, Schempp, Christoph M., Kraus, Margarethe, Walter E Müller, Harteneck Christian, Christoph M. Schempp, Walter E. Müller, Margarethe Kraus, Harteneck, Christian, Beschmann, Heike, Beschmann, Heike A., Boehncke, Wolf-Henning, Beschmann Heike, Boehncke Wolf-Henning, Schempp Christoph M., Kraus Margarethe, Christoph M Schempp, Schempp, Christoph Mathis, Wolf-Henning Boehncke, Heike Beschmann, Christian Harteneck, Woelfle Ute, Leuner Kristina, Leuner, Kristina, Wölfle, Ute, Müller Walter E., Woelfle, Ute, Müller, Walter E.   +28 more
core   +1 more source