Persistent CD8+ T-cell activation (HLA-DR/CD38) as an immunological marker in antiretroviral-treated human immunodeficiency virus-1 patients: A cross-sectional study. [PDF]
Kibar F +7 more
europepmc +1 more source
Scaling of prehospital blood: A model describing impact on U.S. blood donors, distribution and cost
Abstract Background Prehospital transfusion improves survival in traumatic and medical hemorrhage, but the blood supply implications of scaling this capability across U.S. emergency medical services (EMS) systems are unclear. Study Design and Methods We developed an analytic model incorporating national estimates of prehospital transfusion demand, EMS ...
Pampee P. Young +4 more
wiley +1 more source
Beyond histocompatibility: human leukocyte antigen as a cross-disciplinary platform for immune recognition and clinical decision-making. [PDF]
Mandal S +7 more
europepmc +1 more source
Abstract Background Allogeneic hematopoietic stem cell transplantation (HSCT) is a treatment primarily for hematological malignancies. Infections, relapse, and graft versus host disease (GvHD) are some of the most common adverse events following HSCT. We aimed to evaluate whether the lymphocyte function of the stem cell graft was associated with these ...
Anna Söderström +8 more
wiley +1 more source
Cytokine-Mediated Plasticity in the Molecular Requirements for Peptide-Loading Complex Formation and Antigen Presentation. [PDF]
Aranha R +6 more
europepmc +1 more source
Abstract Background Maternal red cell alloimmunization can cause hemolytic disease of the fetus and newborn (HDFN), yet prediction of disease severity remains limited. Biobanks that link pregnancy biospecimens with clinical and laboratory data could accelerate translational research; however, the landscape of relevant obstetric biobanks has not been ...
Orlin Chowdhury +10 more
wiley +1 more source
BeitAI-pHLA: Multiallele Peptide-HLA Class I Binding Prediction Using Protein Language Model and Multi-Instance Learning. [PDF]
Qiu S, Sun Y, Ye X.
europepmc +1 more source
Abstract Background and Objectives Platelet concentrates (PCs) are difficult to manage because of their short shelf‐life and variable clinical demand. The aim of this study was to evaluate the impact of a modified platelet inventory management strategy at a Regional Blood Donation and Treatment Center on product utilization and expiration‐related ...
Anna Lizoń +2 more
wiley +1 more source
Peripheral immune profiling identifies developmental immune displacement into an HLA-DR-low monocyte state in necrotizing enterocolitis. [PDF]
Huang Y +9 more
europepmc +1 more source
ABSTRACT Varicella‐zoster virus (VZV) nomenclature currently recognizes seven established clades (designated 1–6 and 9). A geographical segregation of VZV clades has been shown, with Clades 1, 3, and 6 predominating in Europe, Americas, and Australia, Clade 2 in Japan and East‐Asia, and Clades 4 and 5 in Asia and Africa. This distribution of VZV clades
José Fernandez +7 more
wiley +1 more source

