Results 181 to 190 of about 74,702 (247)

First-in-Human Study of IL15-Activated Cytokine-Induced Killer Cells After Allogeneic HCT Shows Durable Remission and Serotherapy-Associated Immune Reconstitution in Leukemia. [PDF]

J Clin Oncol
Rettinger E, Heckl D, Hutter M, Salzmann-Manrique E, Luedtke M, Huenecke S, Bremm M, Cappel C, Bug G, Greil J, Meisel R, Wagner-Drouet EM, Serve H, Güngör T, Klusmann JH, Klingebiel T, Bader P, Bonig H.   +17 more
europepmc   +1 more source

Roles of Microglia in Cerebral Small Vessel Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Chronic cerebral hypoperfusion triggers microglial activation in cerebral small vessel disease (CSVD). Activated microglia drive neuroinflammation, oxidative stress, and blood–brain barrier disruption, leading to white matter hyperintensities, enlarged perivascular spaces, and other neuroimaging features.
Chenyang Jin, Xiaoqian Song, Yuewen Sun, Yilong Peng, Jing Zhou, Liyan Wang, Xinbao Yin, Xueping Zheng   +7 more
wiley   +1 more source

Integrating Pharmacogenomics and Network Topology for Machine Learning Prediction of HLA-Associated Severe Cutaneous Adverse Drug Reactions. [PDF]

Int J Mol Sci
Ponduan T, Kunsombut A, Paklao T, Suratanee A, Pornputtapong N, Plaimas K.   +5 more
europepmc   +1 more source

Precision medicine for atherosclerotic cardiovascular disease: Integrative genomics maps risk loci and AI‐predicted functional consequences

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Genomic SEM of five ASCVD traits in > 3.8 million individuals identified 347 risk variants, including 19 novel loci. Integrating fine‐mapping and TWAS prioritized causal genes and revealed endothelial cell enrichment in vascular tissues. AI modelling shows the DCLRE1B mutation destabilizes the protein, impairing DNA repair and transcription.
Liwan Fu, Xiaodi Han, Qin Liu, Yuquan Wang, Yue‐Qing Hu   +4 more
wiley   +1 more source

Human leukocyte antigen pharmacogenetics in infectious diseases: anti-infective drug toxicity and host immune response. [PDF]

Front Pharmacol
Negrini S, Nicola S, Badiu I, Quinternetto A, Vitali I, Lo Sardo L, Brussino L.   +6 more
europepmc   +1 more source

Retinol, Carotenoid, and Tocopherol Intake and Status, and the Risk of Islet Autoimmunity and Type 1 Diabetes: The Environmental Determinants of Diabetes in the Young Study

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 5, July 2026.
ABSTRACT Aims To study the associations of dietary intake of A and E vitamins, as well as plasma retinols, carotenoids, and tocopherols in relation to development of islet autoimmunity and progression to T1D. Materials and Methods The Environmental Determinants of Diabetes in the Young (TEDDY) Study followed 7659 newborns with genetic susceptibility to
Leena Hakola, Joanna L. Clasen, Ulla Uusitalo, Carin Andrén Aronsson, Sandra Hummel, Markus Mattila, Sari Niinistö, Jorma Toppari, Anette‐G. Ziegler, William A. Hagopian, Beena Akolkar, Marian J. Rewers, Richard A. McIndoe, Åke Lernmark, Jeffrey P. Krischer, Jill M. Norris, Iris Erlund, Suvi M. Virtanen, the TEDDY Study Group   +18 more
wiley   +1 more source

Multi-omics insights into spondyloarthritis and psoriatic arthritis: integrating genomics, transcriptomics, proteomics, and the microbiome for immunological and clinical translation. [PDF]

Front Immunol
Zhu M, Li R, Wu S, Chen J, Sun K.
europepmc   +1 more source

Transplant versus no transplant outcome in adolescents and adults with sickle cell disease eligible for allogeneic hematopoietic stem cell transplantation

HemaSphere, Volume 10, Issue 7, July 2026.
Abstract Hematopoietic stem cell transplantation (HSCT) remains the only curative option for sickle cell disease (SCD), but its use in adolescents and adults is limited by toxicity concerns. We evaluated the risk–benefit profile of HSCT in this population through a comparative analysis of transplant versus nontransplant strategies. HSCT was analyzed as
Cécile Pivert, Loïc Vasseur, Matthieu Jestin, Edouard Flamarion, Corinne Guitton, Maryse Etienne‐Julan, Abdourahim Chamouine, Laurent Cimasoni, Claire Dichamp, Annie Kamden, Cécile Arnaud, Isabelle Genty, Marie Lagarde, Florence Rabian, Aude M. Fourmont, Florian Chevillon, Bichr Allaf, Laurie Toullec, Jean‐Benoît Arlet, Nicolas Boissel, Corinne Pondarré, Nathalie Dhedin   +21 more
wiley   +1 more source

Immune cell contributions to sarcopenia: Evidence from genetic analyses. [PDF]

Medicine (Baltimore)
Duan Y, Liu J, Lin S, Li X, Luo D, Zhu L.   +5 more
europepmc   +1 more source

Impact of Donor Age, Sex, and ABO Compatibility on Outcomes After Matched Unrelated Donor Hematopoietic Stem Cell Transplantation for Acute Leukemia: A Retrospective Single‐Center Cohort Study

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims Donor‐related factors, including donor age, sex, and ABO compatibility, remain clinically relevant considerations in matched unrelated donor hematopoietic stem cell transplantation (MUD‐HSCT). However, their independent contribution to post‐transplant outcomes in contemporary practice is difficult to define, particularly in
Ghazaleh Kheiri, Mahtab Mashayekhi, Sahar Saeidi, Fatemeh Salemi, Mohammadreza Ostadali Dehaghi, Sahar Tavakoli, Saman Ghavamzadeh, Saeid Mohammadi, Mojtaba Azari, Davood Babakhani, Maryam Barkhordar   +10 more
wiley   +1 more source