Results 211 to 220 of about 70,114,613 (255)

Targeting Amastigote and Trypomastigote Phases: Multi‐Epitope Vaccine Strategy Against Trypanosoma cruzi

Biotechnology and Applied Biochemistry, Volume 73, Issue 5, Page 2457-2481, October 2026.
ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva, Caio Patrício de Souza Sena, Davi Serradella Vieira, Magdi E. A. Zaki, Leow Chiuan Yee, Shahina Akter, Umberto Laino Fulco, Jonas Ivan Nobre Oliveira, João Firmino Rodrigues‐Neto   +8 more
wiley   +1 more source

Beyond the blood-brain barrier: humanised mice, the missing link in glioblastoma research. [PDF]

Oncogene
Shirazi Nia R, Lu J, De Vega D, Poudine N, Pan C, Zhou F, Ji J, Giamas G.   +7 more
europepmc   +1 more source

The Impact of SF3B1 Mutations on the Tumor Microenvironment and Response to Immunotherapy

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Cancer genomes shape the immune landscape within the tumor microenvironment (TME), thereby influencing host antitumor immunity. Identifying somatic mutations that modulate the TME is critical for selecting patients most likely to benefit from immunotherapy.
Kyung‐Jin Cho, Byungho Lim
wiley   +1 more source

Immune cell phenotypes in the context of diabetic nephropathy: A Mendelian randomization analysis. [PDF]

Medicine (Baltimore)
Tong K, Deng J, Yu Y, Xiang Q, Wu J, Pan W, Huang J.   +6 more
europepmc   +1 more source

The Role of Noncoding RNA in MGMT‐Positive Glioblastoma: A Narrative Review

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Glioblastoma (GBM) is the most aggressive primary malignant tumor of the central nervous system and is characterized by rapid progression, frequent recurrence, and poor survival outcomes. The current standard of care, comprising maximal safe surgical resection followed by radiotherapy with concomitant and adjuvant temozolomide (TMZ), has ...
Junfeng Zhao, Jiaxuan Chen, Yingrui Bai, Ying Li, Yiming Han, Chuankun Han, Yintao Li   +6 more
wiley   +1 more source

Multi‐omics integration driving precision medicine in non‐small cell lung cancer: From molecular mechanisms to clinical translation

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review pivots from a conventional technology catalogue to a clinical‐problem‐oriented framework for non‐small cell lung cancer. By integrating spatial multi‐omics, metabolomics, and advanced artificial intelligence (e.g. Multi‐Omics Factor Analysis and Least Absolute Shrinkage and Selection Operator), we decode lipid metabolic reprogramming ...
Yuang Gao, Liyan Lin, Hongrui Zhou, Muchen Li, Yunye Mao, Xiangwei Ge, Yangyang Jia, Yupu Li, Shu Sheng, JinZhao Zhai, Boyu Qin, Jinliang Wang   +11 more
wiley   +1 more source

Exploring the role of monocyte in pulmonary embolism via single‐cell transcriptome sequencing of peripheral blood

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
● Monocyte dysfunction persisted across pulmonary embolism (PE) post‐diagnosis time points. ● ANNEXIN signalling was altered in CD16+ and CD16‐ monocytes. ● CD16+/CD16‐ monocyte communication tracked PE‐associated immune‐state changes. ● S100A8/A9 and FTH1/FTL may be candidate monocyte‐related genes in PE.
Tang Luojia, Tang Cheng, Liu Xuanqi, Huang Yunchuan, Han Yi, Min Min, Song Dongli, Qie Jingbo, Lin Xiaolei, Tong Chaoyang   +9 more
wiley   +1 more source

Investigation of human leukocyte antigen alleles as risk factors for cryptococcal disease in Ugandan individuals with HIV. [PDF]

Hum Immunol
Skipper CP, Dai B, Borges B, Augusto DG, Gerlach E, Tukundane A, Tadeo K, Pastick KA, Williams DA, Kabahubya M, Rajasingham R, Nalintya E, Meya DB, Boulware DR, Hollenbach J, Nielsen K.   +15 more
europepmc   +1 more source

Single‐cell multi‐omics characterises transcriptional and chromatin accessibility heterogeneity of immune cells in allergic rhinitis

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
Key Points 1. SAR and PAR showed distinct immune landscapes. 2. Macro_CCL3 showed phenotype‐specific inflammatory and antigen‐presentation features. 3. CD8_Trm displayed subtype‐associated chromatin accessibility linked to cytotoxicity‐related signatures. 4.
Yisha Wu, Zhihan Xu, Shikai Han, Zhongzhen Liu, Rui Dong, Chuanyu Liu, Jianhua Yin, Jinmei Xue   +7 more
wiley   +1 more source