Results 81 to 90 of about 287,149 (254)

Hexahydroquinoline Featuring Amide Functionality: A Promising Scaffold With Calcium Channel Blocking Activity

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT Hexahydroquinoline (HHQ) is a widely recognized scaffold that has garnered considerable attention owing to its diverse pharmacological properties. The structure of HHQ includes a 1,4‐dihydropyridine (DHP) ring, which serves as the pharmacophore for the predominant class of drugs known as calcium channel blockers.
Ebru Koçak Aslan, Kevin Lam, Sun Huang, Göknil Pelin Coşkun, Ayşe Karagüzel, Katrin Denzinger, Kaan Birgül, Mert Ülgen, Jordan W. Nafie, Onur Şahin, Daniel W. Armstrong, Gerald W. Zamponi, Gerhard Wolber, Miyase Gözde Gündüz   +13 more
wiley   +1 more source

Elevated Polyreactive Immunoglobulin G in Immune‐Mediated Liver Injuries With the Need for Immunosuppressive Therapy

Liver International, Volume 46, Issue 4, April 2026.
ABSTRACT Background & Aims The distinction of drug‐induced liver injury (DILI), drug‐induced autoimmune‐like hepatitis (DI‐ALH), and autoimmune hepatitis (AIH) can be challenging due to overlapping clinical characteristics. Recently, polyreactive immunoglobulin G (pIgG) was identified as a novel biomarker in AIH.
Theresa Kirchner, George N. Dalekos, Kalliopi Zachou, Mercedes Robles‐Díaz, Raúl J. Andrade, Marcial Sebode, Ansgar Lohse, Maciej K. Janik, Piotr Milkiewicz, Mirjam Kolev, Nasser Semmo, Tony Bruns, Tom Jg. Gevers, Benedetta Terziroli Beretta‐Piccoli, Heiner Wedemeyer, Elmar Jaeckel, Richard Taubert, Bastian Engel, pIgG study group   +18 more
wiley   +1 more source

ORMDL Proteins Turnover via Proteasome and Autophagy Is Cell‐Type Dependent and Tied to Ceramide Homeostasis

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
ORMDL proteins in the endoplasmic reticulum (ER) negatively regulate serine palmitoyltransferase (SPT) activity in response to the rate of de novo sphingolipid synthesis. Disruption of ceramide homeostasis by myriocin or fumonisin B1 (FB1) appears to destabilize the ORMDL‐SPT complex, leading to ORMDL degradation as a feedback mechanism.
Michal Mrkacek, Magda Tumova, Alex Puskasu, Pavol Utekal, Marek Vrbacky, Ladislav Kuchar, Petr Draber, Viktor Bugajev   +7 more
wiley   +1 more source

Human Intestinal Microbiota Composition Shapes Model Polyfluoroalkyl Substance Biotransformation

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
Differences in the human gut microbiome impact the rate and pathway of biotransformation for 6:2 polyfluoroalkyl phosphate diester (diPAP), a model polyfluoroalkyl substance. Metabolic analysis is coupled to 16S RNA analysis to identify correlations between microbial taxa abundance and PAP transformation products not previously established from ...
Sierra T. Peskett, Daniel S. Grégoire, Amy A. Rand   +2 more
wiley   +1 more source

Hepatic Metabolism of Sakuranetin and Its Modulating Effects on Cytochrome P450s and UDP-Glucuronosyltransferases

Molecules, 2018
Sakuranetin (SKN), found in cherry trees and rice, is a flavanone with various pharmacological activities. It is biosynthesized from naringenin in rice or cherry trees, and the metabolism of SKN has been studied in non-human species.
Hyesoo Jeong, Jimin Lee, Soolin Kim, Yoo Yeon Yeo, Hyunyoung So, Honghua Wu, Yun Seon Song, Chang-Young Jang, Hee-Doo Kim, Min Jung Kim, Minsun Chang   +10 more
doaj   +1 more source

Multi‐View Biomedical Foundation Models for Molecule‐Target and Property Prediction

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Molecular foundation models can provide accurate predictions for a large set of downstream tasks. We develop MMELON, an approach that integrates pre‐trained graph, image, and text foundation models and validate our multi‐view model on over 120 tasks, including GPCR binding.
Parthasarathy Suryanarayanan, Yunguang Qiu, Shreyans Sethi, Diwakar Mahajan, Hongyang Li, Yuxin Yang, Elif Eyigoz, Aldo Guzmán‐Sáenz, Daniel E. Platt, Timothy H. Rumbell, Kenney Ng, Sanjoy Dey, Myson Burch, Bum Chul Kwon, Pablo Meyer, Feixiong Cheng, Jianying Hu, Joseph A. Morrone   +17 more
wiley   +1 more source

Interaction of a caffeine overdose with clinical doses of contraceptive ethinyl estradiol in a young woman

Acute Medicine & Surgery
Aim The overdose of caffeine, a cytochrome P450 1A2 probe, in young women has become a problem. The aim of this study was to evaluate possible drug interactions between intentionally overdosed caffeine (12 g) and oral contraceptive doses of ethinyl ...
Koichiro Adachi, Maki Murata, Akiyoshi Inada, Takeyori Morimoto, Makiko Shimizu, Satoru Beppu, Hiroshi Yamazaki   +6 more
doaj   +1 more source

Cyanobacteria as multifunctional bioinputs for sustainable intensification, soil health enhancement, and climate resilience in rice‐based cropping systems

Agrosystems, Geosciences &Environment, Volume 9, Issue 1, March 2026.
Abstract Ensuring food security goals through the provision of sustainable energy and food without compromising environmental sustainability is the current requirement amid threats from climate change, uncontrolled global population, and scarcity of natural resources.
Muhammad Shahbaz Farooq, Faiza Javed, Muhammad Uzair, Hossam S. El‐Beltagi, Usman Zulfiqar, Muhammad Ramzan Khan, Muhammad Yousuf, Muximilian Tuckner, Nazih Y. Rebouh, Mohd Asif Shah   +9 more
wiley   +1 more source

Impact of Species and Tissue Differences on In Vitro Glucuronidation of Diclofenac

Molecules
Background: The aim of this study is to determine the impact of species and tissue differences on the glucuronidation of diclofenac in vitro. Method: Microsomes from different species (rat, monkey, mouse, dog, and human) and rat and human tissues (liver,
Eric Asare, Shalom Emmanuel, Ting Du, Huan Xie, Dong Liang, Song Gao   +5 more
doaj   +1 more source

Metabolic Profile Analysis of Designer Benzodiazepine Etizolam in Zebrafish and Human Liver Microsomes. [PDF]

Metabolites, 2023
Jie Z, Qin S, Zhang W, Wang J, Lu J, Qin G, Hou X, Xu P.   +7 more
europepmc   +1 more source