Results 61 to 70 of about 1,184,319 (326)

Mechanisms by which sialylated milk oligosaccharides impact bone biology in a gnotobiotic mouse model of infant undernutrition [PDF]

, 2019
Undernutrition in children is a pressing global health problem, manifested in part by impaired linear growth (stunting). Current nutritional interventions have been largely ineffective in overcoming stunting, emphasizing the need to obtain better ...
Ahern, Philip P., Ahmed, Tahmeed, Barile, Daniela, Barratt, Michael J., Cheng, Jiye, Cowardin, Carrie A., Gordon, Jeffrey I., Guruge, Janaki L., Head, Richard D., Hibberd, Matthew C., Huq, Sayeeda, Kung, Vanderlene L., Mills, David A., Sundaresan, Vinaik   +13 more
core   +2 more sources

The Unsung Heroes: The Profile of the Donor at a Southern Italian Milk Bank and Driving Factors in Human Milk Donation

Children
Background/Objectives: One of the most effective strategies to mitigate morbidity associated with preterm birth is the use of human milk. The first choice is the mother’s milk; if that is not available, human milk donated to milk banks is the second ...
Pasqua Anna Quitadamo, Laura Comegna, Federica Zambianco, Giuseppina Palumbo, Massimiliano Copetti, Maria Assunta Gentile, Antonio Mondelli, Isadora Beghetti, Luigi Corvaglia   +8 more
doaj   +1 more source

Diversity and temporal dynamics of breast milk microbiome and its influencing factors in Chinese women during the first 6 months postpartum

Frontiers in Microbiology, 2022
Human breast milk (HBM) plays an important role in providing nutrients, beneficial microorganisms and bioactive components for infants, helping maturation of their immune system and gastrointestinal development.
Bin Liu, Bin Liu, Junying Zhao, Junying Zhao, Yanpin Liu, Yanpin Liu, Weicang Qiao, Weicang Qiao, Tiemin Jiang, Lijun Chen, Lijun Chen   +10 more
doaj   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

A general model of dioxin contamination in breast milk: results from a study on 94 women from the Caserta and Naples areas in Italy. [PDF]

, 2013
BackgroundThe Caserta and Naples areas in Campania Region experience heavy environmental contamination due to illegal waste disposal and burns, thus representing a valuable setting to develop a general model of human contamination with dioxins (PCDDs ...
Black, Dennis M, Carideo, Pietro, Ceci, Roberta, Cirasino, Lorenzo, Diletti, Gianfranco, Garzillo, Carmine, Giani, Umberto, Giovannini, Armando, Migliorati, Giacomo, Piscitelli, Prisco, Rivezzi, Gaetano, Rivezzi, Giulia, Scortichini, Giampiero   +12 more
core   +2 more sources

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

PRODUCTION OF HIGH LEVELS OF TRANSGENC FACTOR IX WITHOUT GENE RESCUE, AND ITS THERAPEUTIC USES [PDF]

, 2011
A non-human transgenic mammalian animal, as described above, contains an exogenous double stranded DNA sequence stably integrated into the genome of the animal, which comprises cis-acting regulatory units operably linked to a DNA sequence encoding human ...
Cooper, Julian D., O\u27Sickey, Tanya K., Velander, William Hugold   +2 more
core   +1 more source

Understanding the current and future usage of donor human milk in hospitals: An online survey of UK neonatal units

Maternal and Child Nutrition, 2023
The use of donor human milk (DHM) where there is a shortfall of maternal milk can benefit both infant and maternal outcomes but DHM supply is not always assured.
Natalie S. Shenker, Samantha Griffin, Jonathan Hamill‐Keays, Merran Thomson, Judith Simpson, Gillian Weaver   +5 more
doaj   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Oligosaccharides in Milk: Their Benefits and Future Utilization [PDF]

, 2010
The percentage of carbohydrate in the milk/colostrum of the mammalian is range from trace to over 10%, of which disaccharide lactose (Gal(β1-4)Glc) is usually constitutes the major part.
Taufik, E. (E), Urashima, T. (T)
core