Results 41 to 50 of about 8,090,431 (285)

Laboratory analyses for evaluation of platelet disorders and platelet concentrates [PDF]

, 2006
High quality of platelet analytics requires specialized knowledge and skills. It was applied to analyze platelet activation and aggregation responses in a prospective controlled study of patients with Finnish type of amyloidosis.
Javela, Kaija
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Functional changes in hemostasis during asexual and sexual parasitemia in a controlled human malaria infection.

PLoS ONE, 2022
Decreased platelet count is an early phenomenon in asexual Plasmodium falciparum parasitemia, but its association with acute or long-term functional changes in platelets and coagulation is unknown.
Shengshi Huang, Wouter van der Heijden, Isaie J Reuling, Jun Wan, Qiuting Yan, Romy M W de Laat-Kremers, Andre J Van der Ven, Philip G de Groot, Matthew McCall, Robert W Sauerwein, Teun Bousema, Mark Roest, Marisa Ninivaggi, Quirijn de Mast, Bas de Laat   +14 more
doaj   +1 more source

Microfluidic approach to genotyping human platelet antigens

IET Nanobiotechnology, 2012
Centralised laboratories routinely determine blood types by serological and molecular methods. Current practices have limitations in terms of cost, time and accessibility. Miniaturised microfluidic platforms offer an alternative to conventional genotyping methods, since they consume fewer reagents, provide faster analysis and allow for complete ...
C, Lim, D P, Manage, A, Atrazhev, G, Denomme, C J, Backhouse, J P, Acker   +5 more
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Analysis and evaluation of platelet bank establishment strategy from the perspective of donor loss

Zhongguo shuxue zazhi
[Objective] To analyze the loss rate of platelet donors and evaluate the strategies for establishing a platelet donor bank. [Methods] A total of 1 443 donors who joined the HLA and HPA gene donor bank for platelets in Henan Province from 2018 to 2020 ...
LIU Zheng, SUN Yamin, PENG Xin, KANG Yiqing, WANG Ziqing, ZHU Jintong, DU Juan, LI Jianbin   +7 more
doaj   +1 more source

Evaluation of Human Leucocyte Antigen Mediated Platelet Transfusion Refractoriness and Platelet Crossmatching Assay in Patients with Hematologic Disorders

Oman Medical Journal, 2022
Objectives: Platelet refractoriness complicates the platelet transfusion, which is essential for managing thrombocytopenia in patients with hematological disorders. It is associated with adverse clinical outcomes and increased health care costs.
Wafaa A. Neanaey, Akram A. Deghady, Dalia A. Nafea, Nada M. Fahmy, Asmaa M. Gouda   +4 more
doaj   +1 more source

Human platelet antigen allelic diversity in Peninsular Malaysia [PDF]

Immunohematology, 2016
Abstract Human platelet antigens (HPAs) are polymorphic and immunogenic glycoproteins encoded by biallelic genes on human chromosome 17 (HPA-1 to -4 and HPA-6 to -11), chromosome 5 (HPA-5), and chromosome 6 (HPA-15) and expressed on the surface of platelets. In the present study, we typed seven HPA loci (HPA-1 to -
Wan Ubaidillah W, Syafawati, Zulkafli, Zefarina, Zafarina, Zafarina, Mohd Nazri, Hassan, Mohd Nor, Norazmi, Sundararajulu, Panneerchelvam, Geoffrey K, Chambers, Hisham Atan, Edinur   +7 more
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Evidence that platelet-derived microvesicles may transfer platelet-specific immunoreactive antigens to the surface of endothelial cells and CD34+ hematopoietic stem/ progenitor cells--implication for the pathogenesis of immune thrombocytopenias.

Folia Histochemica et Cytobiologica, 2007
The pathogenesis and tissue damage that accompanies destruction of platelets in immune thrombocytopenias (IT) is still not understood very well and in addition to platelets, other cells (e.g.
Mariusz Z Ratajczak, Barbara Zupanska, Jolanta Goźdizk, Ewa Lesko, Jacek Kijowski, Marcin Majka   +5 more
doaj   +1 more source