Results 21 to 30 of about 8,144,169 (239)

Laboratory analyses for evaluation of platelet disorders and platelet concentrates [PDF]

, 2006
High quality of platelet analytics requires specialized knowledge and skills. It was applied to analyze platelet activation and aggregation responses in a prospective controlled study of patients with Finnish type of amyloidosis.
Javela, Kaija
core  

Microfluidic approach to genotyping human platelet antigens

IET Nanobiotechnology, 2012
Centralised laboratories routinely determine blood types by serological and molecular methods. Current practices have limitations in terms of cost, time and accessibility. Miniaturised microfluidic platforms offer an alternative to conventional genotyping methods, since they consume fewer reagents, provide faster analysis and allow for complete ...
C, Lim, D P, Manage, A, Atrazhev, G, Denomme, C J, Backhouse, J P, Acker   +5 more
openaire   +2 more sources

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Semi-quantitative determination of platelet antigens by PAK-12 assay.

, 2016
Semi-quantitative determination of platelet antigens by PAK-12 assay.
Thierry Burnouf (580584), Ying-Jan Weng (3119934), Mette Kjaer (3119928), Liang-Tzung Lin (208214), Björn Skogen (3119931), Anne Husebekk (3119937)   +5 more
core   +1 more source

Methylglyoxal induces platelet hyperaggregation and reduces thrombus stability by activating PKC and inhibiting PI3K/Akt pathway [PDF]

, 2013
Diabetes is characterized by a dysregulation of glucose homeostasis and platelets from patients with diabetes are known to be hyper-reactive and contribute to the accelerated development of vascular diseases.
Voahanginirina Randriamboavonjy, Ingrid Fleming, Amro Elgheznawy, Randriamboavonjy, Voahanginirina, Fleming, Ingrid, Amro Elgheznawy (458464), Karin Hadas, Hadas, Karin, Karin Hadas (458462), Alexander Mann (262817), Elgheznawy, Amro, Mann, Alexander, Ingrid Fleming (132865), Alexander Mann, Voahanginirina Randriamboavonjy (458463), Randriamboavonjy Voahanginirina, Fleming Ingrid, Hadas Karin, Elgheznawy Amro, Mann Alexander   +19 more
core   +1 more source

Human platelet antigen allelic diversity in Peninsular Malaysia [PDF]

Immunohematology, 2016
Abstract Human platelet antigens (HPAs) are polymorphic and immunogenic glycoproteins encoded by biallelic genes on human chromosome 17 (HPA-1 to -4 and HPA-6 to -11), chromosome 5 (HPA-5), and chromosome 6 (HPA-15) and expressed on the surface of platelets. In the present study, we typed seven HPA loci (HPA-1 to -
Wan Ubaidillah W, Syafawati, Zulkafli, Zefarina, Zafarina, Zafarina, Mohd Nazri, Hassan, Mohd Nor, Norazmi, Sundararajulu, Panneerchelvam, Geoffrey K, Chambers, Hisham Atan, Edinur   +7 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Allele frequencies of Human Platelet Antigen 1 and Human Platelet Antigen 5 in the Maltese

, 2021
Background: The human platelet antigen systems consist of antigenic polymorphisms that arise from single base pair substitutions leading to amino acid changes in platelet glycoproteins. These polymorphisms cause a variety of clinically significant conditions where platelet typing is essential for accurate diagnosis and subsequent treatment.
Falzon Lia, Martina, Samut Tagliaferro, Sarah, Farrugia, Rosienne   +2 more
openaire   +1 more source