Results 171 to 180 of about 216,145 (304)

Protocol for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells. [PDF]

STAR Protoc
Adami A, Garza R, Dorazehi F, Douse CH, Jakobsson J.   +4 more
europepmc   +1 more source

Deciphering the Impact of RAC1‐SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models

Advanced Science, EarlyView.
Distal/connecting tubules expressing SLC8A1 have been suggested as a potential origin of ARPKD cysts. SPTAN1 has been identified as a key molecule in ARPKD cyst formation. Restoring SPTAN1 in PKHD1−/− organoids reduced cyst formation, normalized calcium levels, and decreased RAC1/c‐FOS expression, highlighting SPTAN1's role in ARPKD and the potential ...
Shohei Kuraoka, Yuhei Higashi, Suguru Saito, Solmaz Pourgonabadi, Honami Honjoh, Sho Ishigaki, Peter C. Harris, Lisa M. Satlin, Michifumi Yamashita, Ryuji Morizane   +9 more
wiley   +1 more source

How FAIR is metadata for human pluripotent stem cells? [PDF]

Stem Cell Reports
Hu M, Ankeny RA, Santos D, Wells CA.
europepmc   +1 more source

Temporal Interference Stimulation Enhances Neural Regeneration

Advanced Science, EarlyView.
Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressott, Maria Garcia Garrido, Patrycja Dzialecka, Rachel Man Hoi Law, Roberto Portillo‐Lara, Bethany Geary, Elena Faillace, Shirine Merlo‐Nikpay Aslie, Marcelina Wojewska, Maria Otero‐Jimenez, Martina Genta, Luqiao Tan, Karen Duff, Javier Alegre‐Abarrategui, Rylie Green, Nir Grossmann   +15 more
wiley   +1 more source

Dissecting microglial contributions to neurodegenerative disease pathophysiology using human pluripotent stem cells. [PDF]

Stem Cell Reports
Kim D, Kondo T, Inoue H.
europepmc   +1 more source

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

HAND1 controls the lineage bifurcation of trophoblast and amnion from human pluripotent stem cells. [PDF]

Cell Mol Life Sci
Pang C, Yang Q, Zhong Y, Ye J, Lv Y, Xie S, Tang Y, Ye X, Zhang F, Li C, Zhang J, Sun L, Ai S, Gao X.   +13 more
europepmc   +1 more source

The potential of human induced pluripotent stem cells for modelling diabetic wound healing in vitro [PDF]

, 2018
Aasen, Abaci, Abaci, Agha, Ahmed, Ahmed, Al-Awar, American Diabetes Association, Amoh, Annette Graham, Ansell, Ansell, Baltzis, Bielefeld, Bilousova, Blaber, Brouwer, Burkart, Burnett, Buta, Buth, Buth, Catherine S. Wright, Ceder, Chan, Chen, Chichagova, Cory, Davidson, Drawnel, Erin M. O’Shaughnessy, Faller, Faniku, Frank, Fujikura, Gerami-Naini, Girard, Gledhill, Golebiewska, Griscelli, Griscelli, Groeber, Guo, Gurdon, Gurdon, Gurdon, Harvey, Hattersley, Hewitt, Hirsch, Hosokawa, Hu, Hu, Hu, Ianitti, Itoh, Itoh, Kandyba, Kim, Kim, Kogut, Kong, Kwak, Laakso, Lapasset, Levitsky, Li, Liu, Loo, Lotte, Maherali, Maione, Mansbridge, Marion, Marro, Martin, Martinez-Santamaria, Martinez-Santamaria, Matsubara, McCormick, Mewes, Mirza, Mori, Morran, Nissan, Nissan, Nunan, Pane, Park, Patni, Patricia E. Martin, Paull, Peloso, Pennarossa, Peppa, Petrova, Pollok, Prigione, Prodinger, Pugliese, Rajaei, Rittie, Roquet, Rostovskaya, Ruiz, Saarimaki-Vire, Sacks, Salvotelli, Schonberger, Schuster, Seah, Shanmugam, Sharpe, Shi, Shtrichman, Siller, Siller, Siller, Singh, Stagi, Steinberg, Steinle, Sugimoto, Sun, Takahashi, Takahashi, Takahashi, Teo, Teo, Toustrup, Tsourdi, Utikal, Van den Broek, Veraitch, Von Joest, Wallet, Wang, Wenzel, Wicks, Wiegland, Wright, Wright, Wright, Yabe, Yang, Yazdanpanah, Young, Yu, Zaccardi, Zhang, Zomer   +150 more
core   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

bFGF Oligomeric Stability Drives Functional Performance in Human Pluripotent Stem Cells. [PDF]

Int J Mol Sci
Iannitelli DE, Kim N, Ayalew L, Wu Q, Guo XV, Spitler K, Srikanth MP, Camperi J.   +7 more
europepmc   +1 more source