Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle
Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell +3 more
wiley +1 more source
Synthetic thermoresponsive scaffolds for the expansion and differentiation of human pluripotent stem cells into cardiomyocytes. [PDF]
Arrieta-Viana LF +2 more
europepmc +1 more source
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin +5 more
wiley +1 more source
Protocol to rapidly verify silent gene reporter in human pluripotent stem cells using CRISPR activation. [PDF]
Wu Y +4 more
europepmc +1 more source
Role of SoxE transcription factors in development and disease
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source
Jawbone-like organoids generated from human pluripotent stem cells. [PDF]
Motoike S +4 more
europepmc +1 more source
Heterogeneous Single/Dual‐Atom Electrocatalysts in Lithium–Sulfur Batteries
This review summarizes recent advances in single‐atom and dual‐atom electrocatalysts for high‐performance lithium–sulfur batteries. The text systematically covers the classification of catalysts by active metal centers, key synthesis methods, in situ characterization for mechanistic insights, and electrocatalytic mechanisms.
Wenbin Li +3 more
wiley +1 more source
Advancements in the <i>in vitro</i> culture of human pluripotent stem cells: progress, challenges, and future directions: comprehensive review. [PDF]
Chaudhary N, Villa-Diaz LG.
europepmc +1 more source
Cardiac remodeling and arrhythmia in a mouse model of Depdc5 haploinsufficiency
Abstract Objective Some ion channel genes linked to developmental and epileptic encephalopathy (DEE) are also linked to cardiac arrhythmia, leading to the hypothesis that predisposition to cardiac arrhythmias may contribute to the complex disease presentation of DEE and possibly to the mechanism of sudden unexpected death in epilepsy.
Roberto Ramos‐Mondragon +9 more
wiley +1 more source
Cell competition eliminates aneuploid human pluripotent stem cells. [PDF]
Ya A, Deng C, Godek KM.
europepmc +1 more source

