Results 11 to 20 of about 126,711 (266)

Two sides of the same coin? Unraveling subtle differences between human embryonic and induced pluripotent stem cells by Raman spectroscopy

Stem Cell Research & Therapy, 2017
Background Human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells, hold enormous promise for many biomedical applications, such as regenerative medicine, drug testing, and disease modeling.
Elvira Parrotta, Maria Teresa De Angelis, Stefania Scalise, Patrizio Candeloro, Gianluca Santamaria, Mariagrazia Paonessa, Maria Laura Coluccio, Gerardo Perozziello, Stefania De Vitis, Antonella Sgura, Elisa Coluzzi, Vincenzo Mollace, Enzo Mario Di Fabrizio, Giovanni Cuda   +13 more
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Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells. [PDF]

PLoS ONE, 2014
In this study, we aimed to elucidate the effects and mechanism of action of valproic acid on hepatic differentiation from human induced pluripotent stem cell-derived hepatic progenitor cells.
Yuki Kondo, Takahiro Iwao, Sachimi Yoshihashi, Kayo Mimori, Ruri Ogihara, Kiyoshi Nagata, Kouichi Kurose, Masayoshi Saito, Takuro Niwa, Takayoshi Suzuki, Naoki Miyata, Shigeru Ohmori, Katsunori Nakamura, Tamihide Matsunaga   +13 more
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Erythroid differentiation of human induced pluripotent stem cells is independent of donor cell type of origin

Haematologica, 2015
Epigenetic memory in induced pluripotent stem cells, which is related to the somatic cell type of origin of the stem cells, might lead to variations in the differentiation capacities of the pluripotent stem cells.
Isabel Dorn, Katharina Klich, Marcos J. Arauzo-Bravo, Martina Radstaak, Simeon Santourlidis, Foued Ghanjati, Teja F. Radke, Olympia E. Psathaki, Gunnar Hargus, Jan Kramer, Martin Einhaus, Jeong Beom Kim, Gesine Kögler, Peter Wernet, Hans R. Schöler, Peter Schlenke, Holm Zaehres   +16 more
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A Chemical Probe that Labels Human Pluripotent Stem Cells

Cell Reports, 2014
A small-molecule fluorescent probe specific for human pluripotent stem cells would serve as a useful tool for basic cell biology research and stem cell therapy. Screening of fluorescent chemical libraries with human induced pluripotent stem cells (iPSCs)
Nao Hirata, Masato Nakagawa, Yuto Fujibayashi, Kaori Yamauchi, Asako Murata, Itsunari Minami, Maiko Tomioka, Takayuki Kondo, Ting-Fang Kuo, Hiroshi Endo, Haruhisa Inoue, Shin-ichi Sato, Shin Ando, Yoshinori Kawazoe, Kazuhiro Aiba, Koh Nagata, Eihachiro Kawase, Young-Tae Chang, Hirofumi Suemori, Koji Eto, Hiromitsu Nakauchi, Shinya Yamanaka, Norio Nakatsuji, Kazumitsu Ueda, Motonari Uesugi   +24 more
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Stepwise differentiation of functional pancreatic β cells from human pluripotent stem cells

Cell Regeneration, 2022
Pancreatic β cells differentiated from stem cells provide promise for cell replacement therapy of diabetes. Human pluripotent stem cells could be differentiated into definitive endoderm, followed by pancreatic progenitors, and then subjected to ...
Wenwen Jin, Wei Jiang
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Cardiac differentiation of human pluripotent stem cells [PDF]

Journal of Cellular and Molecular Medicine, 2012
AbstractDue to the extremely limited proliferative capacity of adult cardiomyocytes, human embryonic (pluripotent) stem cell derived cardiomyocytes (hESC‐CMs) are currently almost the only reliable source of human heart cells which are suited to large‐scale production.
Jiang, Junjie, Han, Pengcheng, Zhang, Qiangzhe, Zhao, Jianmin, Ma, Yue, Mercola, Mark   +5 more
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The transcriptome of human pluripotent stem cells

Current Opinion in Genetics & Development, 2014
Human Embryonic Stem Cells (hESCs) are in vitro derivatives of the inner cell mass of the blastocyst and are characterized by an undifferentiated and pluripotent state that can be perpetuated in time, indefinitely. hESCs provide a unique opportunity to both dissect the molecular mechanisms that are predisposed to the maintenance of pluripotency and ...
Au, Kin Fai, Sebastiano, Vittorio
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Development of a practical sandwich assay to detect human pluripotent stem cells using cell culture media

Regenerative Therapy, 2017
Human pluripotent stem cells are considered to be ideal cell sources for regenerative medicine, but their clinical and industrial application is hindered by their tumorigenic potential.
Hiroaki Tateno, Keiko Hiemori, Kazunari Hirayasu, Nagako Sougawa, Masakazu Fukuda, Masaki Warashina, Makoto Amano, Taku Funakoshi, Yoshifusa Sadamura, Shigeru Miyagawa, Atsuhiro Saito, Yoshiki Sawa, Tomoko Shofuda, Miho Sumida, Yonehiro Kanemura, Masaya Nakamura, Hideyuki Okano, Yasuko Onuma, Yuzuru Ito, Makoto Asashima, Jun Hirabayashi   +20 more
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DNA repair in human pluripotent stem cells is distinct from that in non-pluripotent human cells. [PDF]

PLoS ONE, 2012
The potential for human disease treatment using human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells (iPSCs), also carries the risk of added genomic instability.
Li Z Luo, Sailesh Gopalakrishna-Pillai, Stephanie L Nay, Sang-Won Park, Steven E Bates, Xianmin Zeng, Linda E Iverson, Timothy R O'Connor   +7 more
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A Method to Identify and Isolate Pluripotent Human Stem Cells and Mouse Epiblast Stem Cells Using Lipid Body-Associated Retinyl Ester Fluorescence

Stem Cell Reports, 2014
We describe the use of a characteristic blue fluorescence to identify and isolate pluripotent human embryonic stem cells and human-induced pluripotent stem cells.
Thangaselvam Muthusamy, Odity Mukherjee, Radhika Menon, Megha Prakash Bangalore, Mitradas M. Panicker   +4 more
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