Results 11 to 20 of about 128,366 (181)
European Journal of Histochemistry, 2012 The reader will immediately get the feeling, from the preface of the book, of handling a laboratory manual where no one needed information is missing: the preface itself is a chapter dealing with the historical reconstruction of the paradigmatic ...
Carlo Alberto Redi
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A plethora of human pluripotent stem cells [PDF]
Cell Biology International, 2013 AbstractAt the early stages of mammalian development, a number of developmentally plastic cells appear that possess the ability to give rise to all of the differentiated cell types normally derived from the three primary germ layers – unique character known as pluripotency. To date, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs)
Liyang, Gao +2 more
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Mechanobiology of Human Pluripotent Stem Cells [PDF]
Tissue Engineering Part B: Reviews, 2013 Human pluripotent stem cells (hPSCs) are self-renewing and have the potential to differentiate into any cell type in the body, making them attractive cell sources for applications in tissue engineering and regenerative medicine. However, in order for hPSCs to find use in the clinic, the mechanisms underlying their self-renewal and lineage commitment ...
Jonathan K, Earls, Sha, Jin, Kaiming, Ye
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hPSCreg—the human pluripotent stem cell registry [PDF]
Nucleic Acids Research, 2015 The human pluripotent stem cell registry (hPSCreg), accessible at http://hpscreg.eu, is a public registry and data portal for human embryonic and induced pluripotent stem cell lines (hESC and hiPSC). Since their first isolation the number of hESC lines has steadily increased to over 3000 and new iPSC lines are generated in a rapidly growing number of ...
Stefanie Seltmann +10 more
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Telomere dynamics in human pluripotent stem cells
Cell Cycle, 2023 Pluripotent stem cells (PSCs) are a promising source of stem cells for regenerative therapies. Stem cell function depends on telomere maintenance mechanisms that provide them with the proliferative capacity and genome stability necessary to multiply and regenerate tissues.
Ma, Buyun +3 more
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Mitochondria in human pluripotent stem cell apoptosis [PDF]
Seminars in Cell & Developmental Biology, 2016 Human pluripotent stem cells (hPSCs) have great potential in regenerative medicine because they can differentiate into any cell type in the body. Genome integrity is vital for human development and for high fidelity passage of genetic information across generations through the germ line.
TeSlaa, Tara +2 more
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The transcriptome of human pluripotent stem cells
Current Opinion in Genetics & Development, 2014 Human Embryonic Stem Cells (hESCs) are in vitro derivatives of the inner cell mass of the blastocyst and are characterized by an undifferentiated and pluripotent state that can be perpetuated in time, indefinitely. hESCs provide a unique opportunity to both dissect the molecular mechanisms that are predisposed to the maintenance of pluripotency and ...
Au, Kin Fai, Sebastiano, Vittorio
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Generation of hypoimmunogenic human pluripotent stem cells [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance To enable cell therapy on a broader scale, the development of universal donor stem cell products that can be administered to multiple patients in need has been proposed, yet a strategy controlling both adaptive and innate immune rejection has not been reported.
Xiao, Han +12 more
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Modeling human infertility with pluripotent stem cells [PDF]
Stem Cell Research, 2017 Human fertility is dependent upon the correct establishment and differentiation of the germline. This is because no other cell type in the body is capable of passing a genome and epigenome from parent to child. Terminally differentiated germline cells in the adult testis and ovary are called gametes. However, the initial specification of germline cells
Chen, Di +4 more
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Regenerative Therapy, 2017 Human pluripotent stem cells are considered to be ideal cell sources for regenerative medicine, but their clinical and industrial application is hindered by their tumorigenic potential.
Hiroaki Tateno +20 more
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