Results 11 to 20 of about 365,728 (264)
A plethora of human pluripotent stem cells [PDF]
Cell Biology International, 2013 AbstractAt the early stages of mammalian development, a number of developmentally plastic cells appear that possess the ability to give rise to all of the differentiated cell types normally derived from the three primary germ layers – unique character known as pluripotency. To date, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs)
Liyang, Gao +2 more
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Mechanobiology of Human Pluripotent Stem Cells [PDF]
Tissue Engineering Part B: Reviews, 2013 Human pluripotent stem cells (hPSCs) are self-renewing and have the potential to differentiate into any cell type in the body, making them attractive cell sources for applications in tissue engineering and regenerative medicine. However, in order for hPSCs to find use in the clinic, the mechanisms underlying their self-renewal and lineage commitment ...
Jonathan K, Earls, Sha, Jin, Kaiming, Ye
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hPSCreg—the human pluripotent stem cell registry [PDF]
Nucleic Acids Research, 2015 The human pluripotent stem cell registry (hPSCreg), accessible at http://hpscreg.eu, is a public registry and data portal for human embryonic and induced pluripotent stem cell lines (hESC and hiPSC). Since their first isolation the number of hESC lines has steadily increased to over 3000 and new iPSC lines are generated in a rapidly growing number of ...
Stefanie Seltmann +10 more
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Periodic formation of epithelial somites from human pluripotent stem cells
Nature Communications, 2022 During embryonic development, epithelial cell blocks called somites are periodically formed according to the segmentation clock, becoming the foundation for the segmental pattern of the vertebral column.
Marina Sanaki-Matsumiya +6 more
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Generation of mature compact ventricular cardiomyocytes from human pluripotent stem cells
Nature Communications, 2021 Compact cardiomyocytes that make up the ventricular wall of the adult heart represent an important therapeutic target population for modeling and treating cardiovascular diseases.
S. Funakoshi +14 more
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Mitochondria in human pluripotent stem cell apoptosis [PDF]
Seminars in Cell & Developmental Biology, 2016 Human pluripotent stem cells (hPSCs) have great potential in regenerative medicine because they can differentiate into any cell type in the body. Genome integrity is vital for human development and for high fidelity passage of genetic information across generations through the germ line.
TeSlaa, Tara +2 more
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Modelling Human Disease with Pluripotent Stem Cells [PDF]
Current Gene Therapy, 2013 Recent progress in the field of cellular reprogramming has opened up the doors to a new era of disease modelling, as pluripotent stem cells representing a myriad of genetic diseases can now be produced from patient tissue. These cells can be expanded and differentiated to produce a potentially limitless supply of the affected cell type, which can then ...
Richard, Siller +3 more
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Telomere dynamics in human pluripotent stem cells
Cell Cycle, 2023 Pluripotent stem cells (PSCs) are a promising source of stem cells for regenerative therapies. Stem cell function depends on telomere maintenance mechanisms that provide them with the proliferative capacity and genome stability necessary to multiply and regenerate tissues.
Ma, Buyun +3 more
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Nature Protocols, 2012 The protocol described here efficiently directs human pluripotent stem cells (hPSCs) to functional cardiomyocytes in a completely defined, growth factor– and serum-free system by temporal modulation of regulators of canonical Wnt signaling.
Xiaojun Lian +8 more
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The transcriptome of human pluripotent stem cells
Current Opinion in Genetics & Development, 2014 Human Embryonic Stem Cells (hESCs) are in vitro derivatives of the inner cell mass of the blastocyst and are characterized by an undifferentiated and pluripotent state that can be perpetuated in time, indefinitely. hESCs provide a unique opportunity to both dissect the molecular mechanisms that are predisposed to the maintenance of pluripotency and ...
Au, Kin Fai, Sebastiano, Vittorio
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