Results 41 to 50 of about 123,070 (267)
Prevention of tumor risk associated with the reprogramming of human pluripotent stem cells
Journal of Experimental & Clinical Cancer Research, 2020 Human pluripotent embryonic stem cells have two special features: self-renewal and pluripotency. It is important to understand the properties of pluripotent stem cells and reprogrammed stem cells.
Kenly Wuputra +5 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
HLA Engineering of Human Pluripotent Stem Cells [PDF]
Molecular Therapy, 2013 The clinical use of human pluripotent stem cells and their derivatives is limited by the rejection of transplanted cells due to differences in their human leukocyte antigen (HLA) genes. This has led to the proposed use of histocompatible, patient-specific stem cells; however, the preparation of many different stem cell lines for clinical use is a ...
Riolobos, Laura +7 more
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Therapeutic effects of induced pluripotent stem cells in chimeric mice with β-thalassemia
Haematologica, 2014 Although β-thalassemia is one of the most common human genetic diseases, there is still no effective treatment other than bone marrow transplantation.
Guanheng Yang +7 more
doaj +1 more source
Stem Cell Research, 2020 Differentiation of mammalian pluripotent cells involves large-scale changes in transcription and, among the molecules that orchestrate these changes, chromatin remodellers are essential to initiate, establish and maintain a new gene regulatory network ...
Ramy Ragheb +8 more
doaj +1 more source
Calcium signaling in human pluripotent stem cells [PDF]
Cell Calcium, 2016 Human pluripotent stem cells provide new tools for developmental and pharmacological studies as well as for regenerative medicine applications. Calcium homeostasis and ligand-dependent calcium signaling are key components of major cellular responses, including cell proliferation, differentiation or apoptosis.
Apáti, Ágota +2 more
openaire +3 more sources
Biobanking of human pluripotent stem cells in China
Cell Proliferation, 2022 AbstractIn recent years, significant progress has been made internationally in the development of human pluripotent stem cell (hPSC)‐derived products for serious and widespread disorders. Biobanking of the cellular starting materials is a crucial component in the delivery of safe and regulatory compliant cell therapies.
Glyn Nigel Stacey, Jie Hao
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Generation of hypoimmunogenic human pluripotent stem cells [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance To enable cell therapy on a broader scale, the development of universal donor stem cell products that can be administered to multiple patients in need has been proposed, yet a strategy controlling both adaptive and innate immune rejection has not been reported.
Xiao, Han +12 more
openaire +2 more sources