Results 51 to 60 of about 365,728 (264)
Requirements for human‐induced pluripotent stem cells
Cell Proliferation, 2022 Abstract‘Requirements for Human‐Induced Pluripotent Stem Cells’ is the first set of guidelines on human‐induced pluripotent stem cells in China, jointly drafted and agreed upon by experts from the Chinese Society for Stem Cell Research. This standard specifies the technical requirements, test methods, and instructions for use, labeling, packaging ...
Ying Zhang +21 more
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Cell Stem Cell, 2018 Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-throughput screening (HTS), but the complexity of organoid cultures poses a significant challenge for miniaturization and automation.
Stefan M Czerniecki +18 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations
Nature, 2017 Human pluripotent stem cells (hPS cells) can self-renew indefinitely, making them an attractive source for regenerative therapies. This expansion potential has been linked with the acquisition of large copy number variants that provide mutated cells with
F. Merkle +16 more
semanticscholar +1 more source
Cell Stem Cell, 2020 SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for physiological models to study SARS-CoV-2 infection using human disease-relevant cells.
Liuliu Yang +36 more
semanticscholar +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
European Journal of Histochemistry, 2012 The reader will immediately get the feeling, from the preface of the book, of handling a laboratory manual where no one needed information is missing: the preface itself is a chapter dealing with the historical reconstruction of the paradigmatic breakthroughts occurred in the last few decades in the stem cell world. I appreciated so much this aspect, a
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Biobanking of human pluripotent stem cells in China
Cell Proliferation, 2022 AbstractIn recent years, significant progress has been made internationally in the development of human pluripotent stem cell (hPSC)‐derived products for serious and widespread disorders. Biobanking of the cellular starting materials is a crucial component in the delivery of safe and regulatory compliant cell therapies.
Glyn Nigel Stacey, Jie Hao
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Haematopoietic stem and progenitor cells from human pluripotent stem cells
Nature, 2017 A variety of tissue lineages can be differentiated from pluripotent stem cells by mimicking embryonic development through stepwise exposure to morphogens, or by conversion of one differentiated cell type into another by enforced expression of master ...
Ryohichi Sugimura +21 more
semanticscholar +1 more source