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DNA repair in human pluripotent stem cells is distinct from that in non-pluripotent human cells. [PDF]
PLoS ONE, 2012 The potential for human disease treatment using human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells (iPSCs), also carries the risk of added genomic instability.
Li Z Luo +7 more
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Clinical potentials of human pluripotent stem cells [PDF]
Cell Biology and Toxicology, 2017 Aging, injuries, and diseases can be considered as the result of malfunctioning or damaged cells. Regenerative medicine aims to restore tissue homeostasis by repairing or replacing cells, tissues, or damaged organs, by linking and combining different disciplines including engineering, technology, biology, and medicine.
MORA, Cristina +4 more
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Stem Cell Reports, 2014 We describe the use of a characteristic blue fluorescence to identify and isolate pluripotent human embryonic stem cells and human-induced pluripotent stem cells.
Thangaselvam Muthusamy +4 more
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Pluripotent States of Human Embryonic Stem Cells [PDF]
Cellular Reprogramming, 2015 Since human embryonic stem cells (hESCs) were first isolated and successfully cultured in vitro, the pluripotent potential of hESCs has been underestimated. The pluripotency of mouse embryonic stem cells (mESCs) can be categorized as naïve and primed, depending on their corresponding in vivo developing phases.
Yifei, Chen, Dongmei, Lai
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Pluripotent Stem Cells as a Model for Human Embryogenesis
Cells, 2023 Pluripotent stem cells (PSCs; embryonic stem cells and induced pluripotent stem cells) can recapitulate critical aspects of the early stages of embryonic development; therefore, they became a powerful tool for the in vitro study of molecular mechanisms that underlie blastocyst formation, implantation, the spectrum of pluripotency and the beginning of ...
Daniela Ávila-González +7 more
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Human pluripotent stem cells in contemporary medicine
Исследования и практика в медицине, 2015 Human pluripotent stem cells (hPSCs) are capable of indefinite proliferation and can be differentiated into any cell type of the human body. Therefore, they are a promising source of cells for treatment of numerous degenerative diseases and injuries ...
S. A. Rodin
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Haematologica, 2010 Background Ex vivo manufacture of red blood cells from stem cells is a potential means to ensure an adequate and safe supply of blood cell products. Advances in somatic cell reprogramming of human induced pluripotent stem cells have opened the door to ...
Hélène Lapillonne +13 more
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Cardiac differentiation of human pluripotent stem cells [PDF]
Journal of Cellular and Molecular Medicine, 2012 AbstractDue to the extremely limited proliferative capacity of adult cardiomyocytes, human embryonic (pluripotent) stem cell derived cardiomyocytes (hESC‐CMs) are currently almost the only reliable source of human heart cells which are suited to large‐scale production.
Jiang, Junjie +5 more
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Genome-wide profiling of pluripotent cells reveals a unique molecular signature of human embryonic germ cells. [PDF]
PLoS ONE, 2012 Human embryonic germ cells (EGCs) provide a powerful model for identifying molecules involved in the pluripotent state when compared to their progenitors, primordial germ cells (PGCs), and other pluripotent stem cells.
Nikta Pashai +7 more
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Scientific Reports, 2017 Human pluripotent stem cells are a potentially powerful cellular resource for application in regenerative medicine. Because such applications require large numbers of human pluripotent stem cell-derived cells, a scalable culture system of human ...
Kazuhiro Ikeda +3 more
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