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Vascular Potential of Human Pluripotent Stem Cells [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2010 Cardiovascular disease is the number one cause of death and disability in the US. Understanding the biological activity of stem and progenitor cells, and their ability to contribute to the repair, regeneration and remodeling of the heart and blood vessels affected by pathological processes is an essential part of the paradigm in enabling us to achieve ...
Ionela, Iacobas +2 more
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Derivation of trophoblast stem cells from naïve human pluripotent stem cells
eLife, 2020 Naïve human pluripotent stem cells (hPSCs) provide a unique experimental platform of cell fate decisions during pre-implantation development, but their lineage potential remains incompletely characterized.
C. Dong +13 more
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Epigenetic aberrations in human pluripotent stem cells [PDF]
The EMBO Journal, 2019 Human pluripotent stem cells (hPSCs) are being increasingly utilized worldwide in investigating human development, and modeling and discovering therapies for a wide range of diseases as well as a source for cellular therapy. Yet, since the first isolation of human embryonic stem cells (hESCs) 20 years ago, followed by the successful reprogramming of ...
Shiran Bar, Nissim Benvenisty
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Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells
Neuron, 2013 Available methods for differentiating human embryonic (ES) and induced pluripotent stem (iPS) cells into neurons are often cumbersome, slow and variable. Alternatively, human fibroblasts can be directly converted into induced neuronal (iN) cells. However,
Yingsha Zhang +15 more
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Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells
Nature Biotechnology, 2020 Generation of pancreatic β cells from human pluripotent stem cells (hPSCs) holds promise as a cell replacement therapy for diabetes. In this study, we establish a link between the state of the actin cytoskeleton and the expression of pancreatic ...
Nathaniel J. Hogrebe +4 more
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Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture
Nature Methods, 2015 The human cerebral cortex develops through an elaborate succession of cellular events that, when disrupted, can lead to neuropsychiatric disease. The ability to reprogram somatic cells into pluripotent cells that can be differentiated in vitro provides a
Anca M. Pașca +14 more
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p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells
Nature Medicine, 2018 CRISPR/Cas9 has revolutionized our ability to engineer genomes and conduct genome-wide screens in human cells1–3. Whereas some cell types are amenable to genome engineering, genomes of human pluripotent stem cells (hPSCs) have been difficult to engineer,
Robert J Ihry +19 more
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Clinical potentials of human pluripotent stem cells [PDF]
Cell Biology and Toxicology, 2017 Aging, injuries, and diseases can be considered as the result of malfunctioning or damaged cells. Regenerative medicine aims to restore tissue homeostasis by repairing or replacing cells, tissues, or damaged organs, by linking and combining different disciplines including engineering, technology, biology, and medicine.
MORA, Cristina +4 more
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Pluripotent States of Human Embryonic Stem Cells [PDF]
Cellular Reprogramming, 2015 Since human embryonic stem cells (hESCs) were first isolated and successfully cultured in vitro, the pluripotent potential of hESCs has been underestimated. The pluripotency of mouse embryonic stem cells (mESCs) can be categorized as naïve and primed, depending on their corresponding in vivo developing phases.
Yifei, Chen, Dongmei, Lai
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Pluripotent Stem Cells as a Model for Human Embryogenesis
Cells, 2023 Pluripotent stem cells (PSCs; embryonic stem cells and induced pluripotent stem cells) can recapitulate critical aspects of the early stages of embryonic development; therefore, they became a powerful tool for the in vitro study of molecular mechanisms that underlie blastocyst formation, implantation, the spectrum of pluripotency and the beginning of ...
Daniela Ávila-González +7 more
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