Results 21 to 30 of about 216,145 (304)

Stepwise differentiation of functional pancreatic β cells from human pluripotent stem cells

Cell Regeneration, 2022
Pancreatic β cells differentiated from stem cells provide promise for cell replacement therapy of diabetes. Human pluripotent stem cells could be differentiated into definitive endoderm, followed by pancreatic progenitors, and then subjected to ...
Wenwen Jin, Wei Jiang
doaj   +1 more source

Regenerative strategies for kidney engineering [PDF]

, 2016
The kidney is the most important organ for water homeostasis and waste excretion. It performs several important physiological functions for homeostasis: it filters the metabolic waste out of circulation, regulates body fluid balances, and acts as an ...
Garreta, Elena, Izpisúa Belmonte, Juan Carlos, Montserrat, Núria   +2 more
core   +1 more source

A Chemical Probe that Labels Human Pluripotent Stem Cells

Cell Reports, 2014
A small-molecule fluorescent probe specific for human pluripotent stem cells would serve as a useful tool for basic cell biology research and stem cell therapy. Screening of fluorescent chemical libraries with human induced pluripotent stem cells (iPSCs)
Nao Hirata, Masato Nakagawa, Yuto Fujibayashi, Kaori Yamauchi, Asako Murata, Itsunari Minami, Maiko Tomioka, Takayuki Kondo, Ting-Fang Kuo, Hiroshi Endo, Haruhisa Inoue, Shin-ichi Sato, Shin Ando, Yoshinori Kawazoe, Kazuhiro Aiba, Koh Nagata, Eihachiro Kawase, Young-Tae Chang, Hirofumi Suemori, Koji Eto, Hiromitsu Nakauchi, Shinya Yamanaka, Norio Nakatsuji, Kazumitsu Ueda, Motonari Uesugi   +24 more
doaj   +1 more source

Development of a practical sandwich assay to detect human pluripotent stem cells using cell culture media

Regenerative Therapy, 2017
Human pluripotent stem cells are considered to be ideal cell sources for regenerative medicine, but their clinical and industrial application is hindered by their tumorigenic potential.
Hiroaki Tateno, Keiko Hiemori, Kazunari Hirayasu, Nagako Sougawa, Masakazu Fukuda, Masaki Warashina, Makoto Amano, Taku Funakoshi, Yoshifusa Sadamura, Shigeru Miyagawa, Atsuhiro Saito, Yoshiki Sawa, Tomoko Shofuda, Miho Sumida, Yonehiro Kanemura, Masaya Nakamura, Hideyuki Okano, Yasuko Onuma, Yuzuru Ito, Makoto Asashima, Jun Hirabayashi   +20 more
doaj   +1 more source

DNA repair in human pluripotent stem cells is distinct from that in non-pluripotent human cells. [PDF]

PLoS ONE, 2012
The potential for human disease treatment using human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells (iPSCs), also carries the risk of added genomic instability.
Li Z Luo, Sailesh Gopalakrishna-Pillai, Stephanie L Nay, Sang-Won Park, Steven E Bates, Xianmin Zeng, Linda E Iverson, Timothy R O'Connor   +7 more
doaj   +1 more source

Prepatterning in the Stem Cell Compartment [PDF]

, 2010
The mechanism by which an apparently uniform population of cells can generate a heterogeneous population of differentiated derivatives is a fundamental aspect of pluripotent and multipotent stem cell behaviour. One possibility is that the environment and
AL Laslett, AM Pietersen, BA Fenderson, CL Bauwens, CS Potten, Daniel Coca, DV Gokhale, DVGaS Kullback, ES Ng, G Guenechea, G Kohler, G Pan, GR Martin, H Akaike, H Akaike, H Bozdogan, H Bozdogan, HH Chang, I Chambers, J Itskovitz-Eldor, J Rossant, J Silva, JKS Wan, K Hayashi, K Huebner, Kelly E. Burrell, KJ Hope, KP Burnham, M Hu, Martin Pera, MR Forster, Peter D. Tonge, Peter W. Andrews, PW Andrews, PW Burridge, Q Gan, QL Ying, R Kannagi, S Delassus, S Erceg, S Huang, S Lowell, SA Kauffman, SC Zhang, SM Chambers, Stephen A. Billings, T Enver, T Enver, TQ Crawford, V Azuara, V Chickarmane, Victor Olariu, Visakan Kadirkamanathan   +52 more
core   +13 more sources

A Method to Identify and Isolate Pluripotent Human Stem Cells and Mouse Epiblast Stem Cells Using Lipid Body-Associated Retinyl Ester Fluorescence

Stem Cell Reports, 2014
We describe the use of a characteristic blue fluorescence to identify and isolate pluripotent human embryonic stem cells and human-induced pluripotent stem cells.
Thangaselvam Muthusamy, Odity Mukherjee, Radhika Menon, Megha Prakash Bangalore, Mitradas M. Panicker   +4 more
doaj   +1 more source

Human pluripotent stem cells in contemporary medicine

Исследования и практика в медицине, 2015
Human pluripotent stem cells (hPSCs) are capable of indefinite proliferation and can be differentiated into any cell type of the human body. Therefore, they are a promising source of cells for treatment of numerous degenerative diseases and injuries ...
S. A. Rodin
doaj   +1 more source

Red blood cell generation from human induced pluripotent stem cells: perspectives for transfusion medicine

Haematologica, 2010
Background Ex vivo manufacture of red blood cells from stem cells is a potential means to ensure an adequate and safe supply of blood cell products. Advances in somatic cell reprogramming of human induced pluripotent stem cells have opened the door to ...
Hélène Lapillonne, Ladan Kobari, Christelle Mazurier, Philippe Tropel, Marie-Catherine Giarratana, Isabelle Zanella-Cleon, Laurent Kiger, Marie Wattenhofer-Donzé, Hélène Puccio, Nicolas Hebert, Alain Francina, Georges Andreu, Stéphane Viville, Luc Douay   +13 more
doaj   +1 more source

Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil [PDF]

, 2018
Purpose of Review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell ...
Aljoufi, Arafat, Broxmeyer, Hal E., Huang, Xinxin, Trinh, Thao   +3 more
core   +1 more source