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Embryonic Chimeras with Human Pluripotent Stem Cells
2019Human pluripotent stem (PS) cells can be isolated from preimplantation embryos or by reprogramming of somatic cells or germline progenitors. Human PS cells are considered the "holy grail" of regenerative medicine because they have the potential to form all cell types of the adult body.
Alejandro, De Los Angeles +2 more
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Pericytes Derived from Human Pluripotent Stem Cells
2018Pericytes wrap blood microvessels and are believed to play important roles in vascular morphogenesis, maturation, and stability. In addition, pericytes have emerged as candidates for targeting cancer growth and for wound healing. In order to model these processes and test new therapies, it is desirable to have a reliable, scalable source of pericytes ...
John, Jamieson +2 more
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Gene Targeting in Human Pluripotent Stem Cells
2011Targeted homologous recombination (HR) is an essential tool in stem cell biology. It can be used to study gene function and is a highly developed technology in the mouse where precise genetic modifications are introduced into the genome via HR in mouse embryonic stem cells (mESCs).
Ying, Liu, Mahendra, Rao
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Maintenance of Human Naïve Pluripotent Stem Cells
2021Naïve pluripotent stem cells are the in vitro counterparts of pre-implantation embryonic epiblast. During the last few years, several protocols for establishing and maintaining human pluripotent stem cells (hPSCs) with naïve features have been reported, and many of these protocols result in cell populations with different molecular characteristics.
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FISH Analysis of Human Pluripotent Stem Cells
2011Human pluripotent stem cells (PSCs) hold promise for treating a multitude of diseases. These fascinating cells are unique in their ability to both self-renew and differentiate into cells from all three germ layers. However, PSCs, as well as other cultured cells, are prone to genetic instability.
Suzanne E, Peterson +2 more
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Human pluripotent stem cells: a progress report
Current Opinion in Genetics & Development, 2001The derivation of diploid human pluripotent stem cell lines from either human blastocysts or embryonic gonads in 1998 attracted a great deal of interest because of the widespread potential applications of these cells in research and in regenerative medicine.
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Human pluripotent stem cells: NIH Guidelines
Molecular Aspects of Medicine, 2001openaire +2 more sources