Results 241 to 250 of about 216,145 (304)

Immune, molecular and genetic profiles of gastric signet ring cell carcinoma: Recent progress and future challenges

International Journal of Cancer, EarlyView.
Abstract Gastric signet ring cell carcinoma (GSRCC) is a special type of gastric cancer common in young women. Diffuse gastric cancer (DGC) begins with intramucosal lesions comprising differentiated GSRCC cells. Genetically, GSRCC and DGC are clonally identical, with their morphology influenced by extracellular Wnt signaling.
Qian Wang, Shuai Zhou, Xiongchao Fang, Xianli He, Gang Wang, Nan Wang   +5 more
wiley   +1 more source

Co-differentiation and enrichment of corneal endothelial cells and keratocytes from human pluripotent stem cells. [PDF]

Sci Rep
Kethiri AR, Grönroos P, Nagaraj ASC, Skottman H.   +3 more
europepmc   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

XPRESSO: Rapid genetic engineering of human pluripotent stem cells for durable overexpression using a modular anti-silencing vector. [PDF]

Stem Cell Reports
Wexler Y, Grinstein H, Huber I, Glatstein S, Ghiringhelli M, Edri O, Landesberg M, Shiff D, Arbel G, Rosh I, Choudhary A, Stern S, Gepstein L.   +12 more
europepmc   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development. [PDF]

Cell Genom
Adami A, Garza R, Gerdes P, Johansson PA, Dorazehi F, Koutounidou S, Castilla-Vallmanya L, Atacho DAM, Sharma Y, Johansson JG, Tam O, Kirkeby A, Barker RA, Hammell MG, Douse CH, Jakobsson J.   +15 more
europepmc   +1 more source

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Leveraging CRISPR activation for rapid assessment of gene editing products in human pluripotent stem cells. [PDF]

Stem Cell Reports
Wu Y, Zhong A, Evangelisti A, Sidharta M, Danwei H, Studer L, Zhou T.   +6 more
europepmc   +1 more source

Production of bioactive cytokines using plant expression system for cardiovascular cell differentiation from human pluripotent stem cells. [PDF]

Stem Cell Res Ther
Murata K, Takamura K, Watanabe R, Nagashima A, Miyauchi M, Miyauchi Y, Masumoto H.   +6 more
europepmc   +1 more source

Endothelial Hydrogels Improve Microvascular Regeneration and Perfusion in Tracheal Scaffolds

The Laryngoscope, EarlyView.
Insufficient vascularization remains a major barrier to successful tracheal transplantation. This study demonstrates that an endothelial hydrogel significantly enhances graft perfusion and neovessel organization compared to non‐endothelial hydrogel controls.
Molly O. Hunter, Lumei Liu, Nathaniel Hochuli, Olivia Chan, Jazmin Calyeca, Ada C. Sher, Tendy Chiang   +6 more
wiley   +1 more source