Results 231 to 240 of about 216,145 (304)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Tapered Pillar Design for High-Precision Force Readout in Miniaturized Engineered Heart Tissues From Human Pluripotent Stem Cells. [PDF]

Adv Healthc Mater
Dostanić M, Wiendels M, Windt LM, Mol MPH, van den Hil FE, Davis RP, Orlova V, van Meer BJ, Mastrangeli M, Mummery CL.   +9 more
europepmc   +1 more source

Integrative genomic and spatial transcriptomic analysis elucidates the oligodendrocyte‐mediated etiology of epileptic cortical thinning

Epilepsia Open, EarlyView.
Abstract Objective Focal epilepsy is characterized by progressive cortical thinning, particularly within limbic structures; however, whether this atrophy reflects acquired seizure‐induced damage or shared genetic predisposition remains unresolved. Methods We integrated genome‐wide association study (GWAS) summary statistics from the ILAE Consortium ...
Dingyuan Zhang, Qianqian Zhang, Guangming Li, Lingting Yu, Yanling Ma, Xiaoli Hong, Yujie Kui, Shanshan Cai, Jianguang Sun, Zechao Zhu   +9 more
wiley   +1 more source

Serine synthesis pathway regulates cardiac differentiation from human pluripotent stem cells. [PDF]

iScience
Umei TC, Tohyama S, Morita-Umei Y, Katoh M, Nomura S, Haga K, Hishiki T, Matsuura T, Tani H, Soma Y, Sekine O, Ohno M, Nakamura M, Moriwaki T, Kishino Y, Fukuda K, Ieda M.   +16 more
europepmc   +1 more source

Review of articular cartilage repair techniques and their application in the horse

Equine Veterinary Journal, EarlyView.
Abstract Articular cartilage lesions represent a significant career‐limiting problem in athletic horses. A healthy articular cartilage surface is vital for optimal joint function, and defects can result in irreversible degenerative changes. Successful treatment of cartilage lesions remains a long‐standing challenge for orthopaedic surgeons, prompting ...
Charlotte K. Barton, Brad B. Nelson, Laurie R. Goodrich   +2 more
wiley   +1 more source

Generation and characterization of vestibular inner ear organoids from human pluripotent stem cells. [PDF]

Nat Protoc
van der Valk WH, Nist-Lund C, Zhang J, Perea C, Jin J, Gim KY, Steinhart MR, Lee J, Koehler KR.   +8 more
europepmc   +1 more source

Bioactive Magnesium Silicate Activating Myocardial Energy Metabolism For Infarcted Myocardium Repair

Exploration, EarlyView.
ABSTRACT The heart is a highly energy‐dependent organ, developing bioenergy‐activating biomaterials to activate myocardial adenosine triphosphate (ATP) production and restore dysregulated energy homeostasis is a promising solution for its functional recovery.
Zhibin Liao, Chen Qin, Erhong Song, Chengbin Ding, Zhixu Wang, Yan Sun, Chen Song, Junjie Liu, Jingge Ma, Hongjian Zhang, Leyu Wang, Chengtie Wu   +11 more
wiley   +1 more source

Correction: Spatial cell fate manipulation of human pluripotent stem cells by controlling the microenvironment using photocurable hydrogel. [PDF]

Development
Wang Z, Numada A, Wagai F, Oda Y, Ohgushi M, Maki K, Adachi T, Eiraku M.   +7 more
europepmc   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Depletion of TP53 in Human Pluripotent Stem Cells Triggers Malignant-Like Behavior. [PDF]

Adv Biol (Weinh)
Montilla-Rojo J, Eleveld TF, van Soest M, Hillenius S, Timmerman DM, Gillis AJM, Roelen BAJ, Mummery CL, Looijenga LHJ, Salvatori DCF.   +9 more
europepmc   +1 more source