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Naiveté of the human pluripotent stem cell
Nature Biotechnology, 2014Human pluripotent stem cells can be stabilized in a state resembling the inner cell mass of the blastocyst.
Mascetti, Victoria L, Pedersen, Roger A
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Glycomics of human embryonic stem cells and human induced pluripotent stem cells
Glycoconjugate Journal, 2016Most cells are coated by a dense glycocalyx composed of glycoconjugates such as glycosphingolipids, glycoproteins, and proteoglycans. The overall glycomic profile is believed to be crucial for the diverse roles of glycans, which are mediated by specific interactions that regulate cell-cell adhesion, the immune response, microbial pathogenesis, and ...
Jun-Ichi, Furukawa +2 more
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Authentication and Banking of Human Pluripotent Stem Cells
Current Protocols in Stem Cell Biology, 2009AbstractPluripotent human stem cell lines from embryos or reprogrammed adult cells are not all alike. Cell lines differ widely in their propensity for differentiation, their chromosomal integrity and epigenetic state, immunological profiles, and their availability for research.
Richard, Josephson, Jonathan, Auerbach
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Human Pluripotent Stem Cell Differentiation to Microglia
2021Microglia, the immune cells of the central nervous system (CNS), play critical roles in CNS homeostasis and disease. Mounting evidence has linked aberrant microglial functions to neurodevelopment, neuroinflammatory and neurodegenerative diseases, underlining the need for novel models to investigate human microglia biology.
Laraib, Ijaz +2 more
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Epigenome rewiring in human pluripotent stem cells
Trends in Cell Biology, 2022The epigenome plays a crucial role in modulating the activity of regulatory elements, thereby orchestrating diverse transcriptional programs during embryonic development. Human (h)PSC stepwise differentiation provides an excellent platform for capturing dynamic epigenomic events during lineage transition in human development. Here we discuss how recent
Jielin Yan, Danwei Huangfu
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Pluripotent Hemopoietic Stem Cells in Mice and Humans
Proceedings of the Society for Experimental Biology and Medicine, 2000Abstract. Although it has been reported previously that pluripotent hemopoietic stem cells (P‐HSCs) express c‐kit, the receptor for stem cell factor (steel factor), we and other groups have recently shown that P‐HSCs do not express c‐kit. In this review, we provide evidence that c‐kit<low P‐HSCs in mice have long‐term‐reconstituting activity (LTRA ...
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Bioenergetic Profiling of Human Pluripotent Stem Cells
2021Cellular metabolism contributes to cell fate decisions. Bioenergetic profiling can therefore provide considerable insights into cellular identity and specification. Given the current importance of human pluripotent stem cells (hPSCs) for biomedical applications, assessing the bioenergetic properties of hPSCs and derivatives can unveil relevant ...
Gizem, Inak +2 more
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Embryonic Chimeras with Human Pluripotent Stem Cells
2019Human pluripotent stem (PS) cells can be isolated from preimplantation embryos or by reprogramming of somatic cells or germline progenitors. Human PS cells are considered the "holy grail" of regenerative medicine because they have the potential to form all cell types of the adult body.
Alejandro, De Los Angeles +2 more
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Regenerating the nephron with human pluripotent stem cells
Current Opinion in Organ Transplantation, 2015Nephrogenesis in humans is limited to the period of embryonic kidney development in utero, with no new nephrons formed after birth. Although the kidneys possess the capacity to self-repair segments of the nephron, nephron loss from acute or chronic kidney injury is irreversible and results in impaired function.
Albert Q, Lam, Joseph V, Bonventre
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Gene Targeting in Human Pluripotent Stem Cells
2011Targeted homologous recombination (HR) is an essential tool in stem cell biology. It can be used to study gene function and is a highly developed technology in the mouse where precise genetic modifications are introduced into the genome via HR in mouse embryonic stem cells (mESCs).
Ying, Liu, Mahendra, Rao
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