Results 71 to 80 of about 2,739,043 (309)
, 2002 Recent empirical and theoretical work suggests that reputation was an important mediator of access to resources in ancestral human environments. Reputations were built and maintained by the collection, analysis, and dissemination of information about ...
Hagen, Edward H., Hess, Nicole C.
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Serbian labor market with special emphasis on defining marketing strategy in tourism [PDF]
In addition to clear negative impact of the global economic crisis, which we witness, the labor market in Serbia has been faced with the transition problems accumulated through many years. Tourism and hospitality are among the those activities which have
Dakic, Stojanka, Fabian, Ksenija
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
An Analysis of Strategy Formulation for Halal Hotel Human Resources in Indonesia
Cogent Business & Management, 2020 The emergence of halal hotel businesses has attracted many scholars’ and practitioners’ attention. However, the halal hotel concept and the required human resources are still not very clear. This study aims to examine the internal and external aspects of
Joeliaty Joeliaty +2 more
doaj +1 more source
Disease Surveillance Networks Initiative Asia: Final Evaluation [PDF]
, 2010 The DSN Initiative was launched in 2007 under the new strategy of the Rockefeller Foundation. The initiative intends:[1] To improve human resources for disease surveillance in developing countries, thus bolstering national capacity to monitor, report ...
Caridad A. Ancheta +7 more
core
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
THE MANAGEMENT OF SCIENTIFIC RESEARCH AND ITS PLACE IN THE UNIVERSITY ACTIVITY [PDF]
In the last two decades, the research in general and in particular the universities research has gained a special importance. The competition for the resources and in particular for the human resources, the higher education transformations in recent ...
Loredana VÄ‚CÄ‚RESCU HOBEANU
core
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source